Subchronic inhalation of a novel electronic nicotine delivery system formulation and its corresponding base formulation
Guy Lalonde,
Nikos Tsolakos,
Tessa R Moir-Savitz
et al.
Abstract:Background Fresh Menthol 3% Nicotine (FM3) is a novel JUUL e-liquid formulation. Its potential toxicity and that of the corresponding base formulation relative to a filtered air (FA) control was studied in a subchronic inhalation study conducted in general accordance with OECD 413. Methods Aerosols generated with an intense puffing regime were administered to rats in a nose-only fashion at 1400 µg aerosol collected mass/L on a 6 hour/day basis for 90 days with a 42-day recovery. Exposure atmospheres met target… Show more
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