Subchronic effects of environment-like cadmium levels on the bivalve<i>Anodonta anatina</i>(Linnaeus 1758): II. Effects on energy reserves in relation to calcium metabolism

Ngo, Huong Thi Thuy; Gerstmann, Silke; Hartmut, Frank

doi:10.1080/02772240802503585

Cited by 11 publications

(3 citation statements)

References 39 publications

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“…Glycogen can be used as an energy substrate through glycogenolysis [29], and its depletion means more energy consumed for defense of environmental stresses [30]. In the present study, glycogen content in the digestive gland was negatively affected by Cu, indicating that the digestive gland was Physiological and cellular responses of oysters to metals Environ Toxicol Chem 35, 2016Chem 35, 2583 the major site for energy reserve, which may be significantly affected by Cu.…”

Section: Biomarkersmentioning

confidence: 53%

Physiological and cellular responses of oysters (Crassostrea hongkongensis) in a multimetal‐contaminated estuary

Wang

2016

Enviro Toxic and Chemistry

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The Pearl River estuary, southern China, suffers from multiple sources of metal contamination as a result of the rapid industrial development in the region; but the biological impacts of contamination remain unknown. In the present study, a euryhaline oyster, Crassostrea hongkongensis, was collected from different sites of the Pearl River estuary; and various physiological (heart rate, alkaline phosphatase as homeostatic regulation, and glycogen as energy reserve) and cytological (lysosomal membrane stability) biomarkers were quantified to assess this species as a potential bioindicator of metal pollution in contaminated areas. Large variations of metal accumulation levels in the oysters were documented, especially for copper (Cu), zinc (Zn), cadmium (Cd), chromium, and nickel (Ni). Among these metals, the authors demonstrated significant correlations between the digestive gland metal accumulation of Cu, Zn, and Ni and the cellular homeostasis (alkaline phosphatase) and glycogen reserves. Heart rate was positively correlated with Cd but negatively correlated with Cu and Zn concentrations in the gills. Lysosomal membrane stability was significantly inhibited at the most contaminated sites but had no relationship with the accumulated metal concentrations. These measurements indicate that multimetal contamination in the Pearl River estuary impacts the physiological and cytological performance of oysters. Environ Toxicol Chem 2016;35:2577-2586. © 2016 SETAC.

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Section: Biomarkersmentioning

confidence: 53%

Physiological and cellular responses of oysters (Crassostrea hongkongensis) in a multimetal‐contaminated estuary

Wang

2016

Enviro Toxic and Chemistry

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“…However, unlike at day 5, where none of the putatively identified carbohydrates were significantly different from the controls ( p ≤ 0.05), all of them were increased by day 10 (Table ). This is a classic biomarker of contaminant exposure in bivalves (Ngo et al ) because these carbohydrate reserves can be utilized to provide immediate metabolic fuel to deal with a stressor (Leonard et al ). Although it is not clear why this was the only treatment that showed this delayed response, a possible explanation is biotransformation of diphenhydramine to its primary active metabolite nordiphenhydramine, as well as dinordiphenhydramine and diphenylmethoxyacetic acid (Akutsu et al ).…”

Section: Resultsmentioning

confidence: 99%

Metabolomic Investigations of the Temporal Effects of Exposure to Pharmaceuticals and Personal Care Products and Their Mixture in the Eastern Oyster (Crassostrea virginica)

Brew

Black

Santos

et al. 2020

Enviro Toxic and Chemistry

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The eastern oyster (Crassostrea virginica) supports a large aquaculture industry and is a keystone species along the Atlantic seaboard. Native oysters are routinely exposed to a complex mixture of contaminants that increasingly includes pharmaceuticals and personal care products (PPCPs). Unfortunately, the biological effects of chemical mixtures on oysters are poorly understood. Untargeted gas chromatography-mass spectrometry metabolomics was utilized to quantify the response of oysters exposed to fluoxetine, N,N-diethyl-meta-toluamide, 17α-ethynylestradiol, diphenhydramine, and their mixture. Oysters were exposed to 1 µg/L of each chemical or mixture for 10 d, followed by an 8-d depuration period. Adductor muscle (n = 14/treatment) was sampled at days 0, 1, 5, 10, and 18. Trajectory analysis illustrated that metabolic effects and class separation of the treatments varied at each time point and that, overall, the oysters were only able to partially recover from these exposures post-depuration. Altered metabolites were associated with cellular energetics (i.e., Krebs cycle intermediates), as well as amino acid metabolism and fatty acids. Exposure to these PPCPs also affected metabolic pathways associated with anaerobic metabolism, osmotic stress, and oxidative stress, in addition to the physiological effects of each chemical's postulated mechanism of action. Following depuration, fewer metabolites were altered, but none of the treatments returned them to their initial control values, indicating that metabolic disruptions were long-lasting. Interestingly, the mixture did not directly cluster with individual treatments in the scores plot from partial least squares discriminant analysis, and many of its affected metabolic pathways were not well predicted from the individual treatments. The present study highlights the utility of untargeted metabolomics in developing exposure biomarkers for compounds with different modes of action in bivalves. Environ Toxicol Chem 2020;39:419-436.

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“…In this study, glucose levels in the digestive gland of mussels exposed to acoustic stimulation was evaluated. It was previously shown that haemolymphatic glucose levels increased in M. galloprovincialis after exposure to acoustic stimulation (Vazzana et al, 2016); probably due to a decrease in glycogen content in the digestive gland as a result of highglycolytic activity (Pekkarinen and Suoranta, 1995;Ngo et al, 2011). In fact, Sonawane and Sonawane (2018) reported that during acute and chronic stress exposure, a significant reduction in glycogen content in the digestive gland was occurred.…”

Section: B Noise Effects On the Digestive Glandmentioning

confidence: 96%

Effects of acoustic stimulation on biochemical parameters in the digestive gland of Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819)

Vazzana

Ceraulo

Mauro

et al. 2020

The Journal of the Acoustical Society of America

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Underwater sounds generated by anthropogenic activity can cause behavior changes, temporary loss of hearing, damage to parts of the body, or death in a number of marine organisms and can also affect healing and survival. In this study, the authors examined the effects of high-frequency acoustic stimulations on a number of biochemical parameters in the Mediterranean mussel, Mytilus galloprovincialis. During the experiment, animals were placed in a test tank and exposed to acoustic signals [a linear sweep ranging from 100 to 200 kHz and lasting 1 s, with a sound pressure level range of between 145 and 160 dBrms (re 1μParms)] for 3 h. Total haemocyte count was assessed and glucose levels, cytotoxic activity and enzyme activity (alkaline phosphatase, esterase and peroxidase) in the digestive gland were measured. For the first time, this study suggests that high-frequency noise pollution has a negative impact on biochemical parameters in the digestive gland.

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Subchronic effects of environment-like cadmium levels on the bivalveAnodonta anatina(Linnaeus 1758): II. Effects on energy reserves in relation to calcium metabolism

Cited by 11 publications

References 39 publications

Physiological and cellular responses of oysters (Crassostrea hongkongensis) in a multimetal‐contaminated estuary

Physiological and cellular responses of oysters (Crassostrea hongkongensis) in a multimetal‐contaminated estuary

Metabolomic Investigations of the Temporal Effects of Exposure to Pharmaceuticals and Personal Care Products and Their Mixture in the Eastern Oyster (Crassostrea virginica)

Effects of acoustic stimulation on biochemical parameters in the digestive gland of Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819)

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