Subchronic effects of dipyrone on the fish species Rhamdia quelen

Pamplona, Juliana Helena; Oba, Eliane Tie; Silva, Thiago Alessandre da; Ramos, Luiz Pereira; Ramsdorf, Wanessa Algarte; Cestari, Marta M.; Ribeiro, Ciro Alberto de Oliveira; Zampronio, Aleksander Roberto; Assis, Helena C. Silva de

doi:10.1016/j.ecoenv.2010.09.010

Cited by 47 publications

(16 citation statements)

References 44 publications

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“…Diclofenac reduced the GST activity in liver of H. malabaricus, demonstrating that biotransformation was inhibited. Dipyrone, other NSAID, diminished the GST activity in Rhamdia quelen subchronically exposed (Pamplona et al, 2011). However, others studies reported GST increase in NSAIDs exposure.…”

Section: Discussionmentioning

confidence: 94%

Effects of trophic exposure to dexamethasone and diclofenac in freshwater fish

Guiloski

Ribas

Pereira

et al. 2015

Ecotoxicology and Environmental Safety

108

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Section: Discussionmentioning

confidence: 94%

Effects of trophic exposure to dexamethasone and diclofenac in freshwater fish

Guiloski

Ribas

Pereira

et al. 2015

Ecotoxicology and Environmental Safety

108

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“…In contrast, we were unable to find monitoring information for pharmaceuticals and personal care products. These contaminants were not further assessed to identify contaminants of concern for this review, but if present in Gladstone Harbour may contribute to fish biomarker responses [60, 61]. …”

Section: Resultsmentioning

confidence: 99%

A protocol for identifying suitable biomarkers to assess fish health: A systematic review

2017

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BackgroundBiomarkers have been used extensively to provide the connection between external levels of contaminant exposure, internal levels of tissue contamination, and early adverse effects in organisms.ObjectivesTo present a three-step protocol for identifying suitable biomarkers to assess fish health in coastal and marine ecosystems, using Gladstone Harbour (Australia) as a case study.MethodsPrior to applying our protocol, clear working definitions for biomarkers were developed to ensure consistency with the global literature on fish health assessment. First, contaminants of concern were identified based on the presence of point and diffuse sources of pollution and available monitoring data for the ecosystem of interest. Second, suitable fish species were identified using fisheries dependent and independent data, and prioritised based on potential pathways of exposure to the contaminants of concern. Finally, a systematic and critical literature review was conducted on the use of biomarkers to assess the health of fish exposed to the contaminants of concern.Results/DiscussionWe present clear working definitions for bioaccumulation markers, biomarkers of exposure, biomarkers of effect and biomarkers of susceptibility. Based on emission and concentration information, seven metals were identified as contaminants of concern for Gladstone Harbour. Twenty out of 232 fish species were abundant enough to be potentially suitable for biomarker studies; five of these were prioritised based on potential pathways of exposure and susceptibility to metals. The literature search on biomarkers yielded 5,035 articles, of which 151met the inclusion criteria. Based on our review, the most suitable biomarkers include bioaccumulation markers, biomarkers of exposure (CYP1A, EROD, SOD, LPOX, HSP, MT, DNA strand breaks, micronuclei, apoptosis), and biomarkers of effect (histopathology, TAG:ST).ConclusionOur protocol outlines a clear pathway to identify suitable biomarkers to assess fish health in coastal and marine ecosystems, which can be applied to biomarker studies in aquatic ecosystems around the world.

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“…Pamplona et al (2011) found an increase in GST activity after exposure to dipyrone at 50 g/l, as did Stepanova et al (2013). In their study, GST activity was significantly higher at a diclofenac concentration of 3 mg/l compared to the control.…”

Section: Discussionmentioning

confidence: 84%

“…Pamplona et al (2011), who studied the effects of dipyrone on Rhamdia quelen adults, did not observe changes in CAT activity after exposure to 0.5, 5, and 50 g/l of dipyrone. However, Zivna et al (2013) found an increase in CAT activity in fish exposed to acetylsalicylic acid at concentrations of 0.004, 0.4, 40 and 120 mg/l, with a significant increase at 40 mg/l.…”

Section: Discussionmentioning

confidence: 92%