Subchromosomal assignment&lt;footref rid="foot01"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/footref&gt; of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster

Scelfo, Rosaria; Sabbioni, Silvia; Barbanti-Brodano, G.; Negrini, Massimo

doi:10.1159/000015123

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…TSSC1 was previously identified as the product of a gene encoded in the subchromosomal 11p15.5 tumor-suppressor gene region ( Hu et al ., 1997 ; Scelfo et al ., 1998 ) and regulated by the transcription factor Runx2 ( Wang et al ., 2013 ). The human gene encodes a 387–amino acid protein with a predicted molecular mass of 43.6 kDa.…”

Section: Resultsmentioning

confidence: 99%

TSSC1 is novel component of the endosomal retrieval machinery

Gershlick

Schindler

Chen

et al. 2016

MBoC

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Section: Resultsmentioning

confidence: 99%

TSSC1 is novel component of the endosomal retrieval machinery

Gershlick

Schindler

Chen

et al. 2016

MBoC

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“…Rescue of Ca 2+ oscillations by TRPC3 in HEK cells in which STIM1 was KD was taken to suggest that TRPC3 is not regulated by STIM1 [50]. However, since cells express multiple TRPC channels [16,22,23,51], and several TRPC channels interact with each other or are present in the same Ca 2+ signaling complexes [44][45][46][52][53][54][55][56][57][58], it is necessary to examine the role of STIM1 in the activity of each of the TRPC channels before it is known which of these channels are regulated by STIM1 and how STIM1 gates each of the channels. The predicted two-turn helix of the C-terminal tail of STIM1.…”

Section: Regulation Of Trpc Channels By Stim1mentioning

confidence: 99%

TRPC channels as STIM1-regulated store-operated channels

et al. 2007

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Receptor-activated Ca 2+ influx is mediated largely by store-operated channels (SOCs). TRPC channels mediate a significant portion of the receptor-activated Ca 2+ influx. However, whether any of the TRPC channels function as a SOC remains controversial. Our understanding of the regulation of TRPC channels and their function as SOCs is being reshaped with the discovery of the role of STIM1 in the regulation of Ca 2+ influx channels. The findings that STIM1 is an ER resident Ca 2+ binding protein that regulates SOCs allow an expanded and molecular definition of SOCs. SOCs can be considered as channels that are regulated by STIM1 and require the clustering of STIM1 in response to depletion of the ER Ca 2+ stores and its translocation towards the plasma membrane. TRPC1 and other TRPC channels fulfill these criteria. STIM1 binds to TRPC1, TRPC2, TRPC4 and TRPC5 but not to TRPC3, TRPC6 and TRPC7, and STIM1 regulates TRPC1 channel activity. Structure-function analysis reveals that the C-terminus of STIM1 contains the binding and gating function of STIM1. The ERM domain of STIM1 binds to TRPC channels and a lysine-rich region participates in the gating of SOCs and TRPC1. Knock-down of STIM1 by siRNA and prevention of its translocation to the plasma membrane inhibit the activity of native SOCs and TRPC1. These findings support the conclusion that TRPC1 is a SOC. Similar studies with other TRPC channels should further clarify their regulation by STIM1 and function as SOCs.

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Array comparative genomic hybridization in male infertility

et al. 2012

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Eight deletions/duplications were absent in our control group, and therefore might be linked with the male infertility in our patients. One of these alterations, however, has been detected in a proven fertile father group. Further research is necessary to determine the relationship between the observed genomic alterations and maturation arrest of spermatogenesis. Furthermore, several of the above genes have not been studied at the functional level and consequently, more research is required to determine their role in spermatogenesis.

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Subchromosomal assignment<footref rid="foot01"><sup>1</sup></footref> of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster

Cited by 3 publications

References 3 publications

TSSC1 is novel component of the endosomal retrieval machinery

TSSC1 is novel component of the endosomal retrieval machinery

TRPC channels as STIM1-regulated store-operated channels

Array comparative genomic hybridization in male infertility

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