Subchorionic hematoma and pregnancy outcomes in patients with threatened miscarriage

Naz, Sumaira; Irfan, Sheikh; Naru, Tahira; Malik, Ayesha

doi:10.12669/pjms.38.3.4283

Cited by 9 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data suggest that SCH presenting in the first trimester does not adversely affect neonatal outcomes, similar to the conclusions of several current studies. [7,21] However, some studies [22] have found that the presence of SCH can lead to an increased risk of small gestational age infants. At present, there is no consensus on the relationship between SCH and adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

Analysis of risk factors and pregnancy outcomes in pregnant women with subchorionic hematoma

Xu,

Lun,

Wang

et al. 2023

Medicine

View full text Add to dashboard Cite

Subchorionic hemorrhage (SCH) or hematoma is one of the abnormal ultrasonic manifestations. At present, there are few studies on the pathogenesis of SCH, and its underlying mechanism is still unclear. It may be related to abnormal placenta formation and implantation, autoimmune dysfunction, and coagulation dysfunction. As a unique complication of pregnancy, SCH has a controversial effect on pregnancy outcome. The aim of the present study was to explore the possible etiology of SCH, especially its association with autoimmune dysfunctions, as well as the pregnancy outcomes of SCH patients. This retrospective cohort study was conducted at the Third Affiliated Hospital of Zhengzhou University. Patients with a singleton pregnancy of ≤14 weeks gestation from June 2021 to June 2022 were included. Patients with SCH detected by ultrasound were selected as the study group, while patients without SCH during the same period were chosen as the control group. Immunological indicators and pregnancy outcomes were primarily compared between the 2 groups. The decrease in protein S activity and antithrombin-III levels, the increase in homocysteine levels, and the presence of autoantibodies (such as lupus anticoagulant, anticardiolipin antibody, and antinuclear antibody spectrum) were found to be risk factors for SCH. SCH in the first trimester was associated with higher rates of premature rupture of membranes (13.5% vs 3.8%) and miscarriage (14.4% vs 6.4%). However, there were no significant differences in the rates of placental abruption, fetal distress, cesarean section, neonatal birth weight, and gestational age. The incidence of miscarriage was also significantly higher in patients with subchorionic hematoma (SCH) who tested positive for autoantibodies (28.2% vs 7.6%). There were no significant differences in other clinical characteristics and pregnancy outcomes between patients with SCH who had positive autoantibodies and those who did not. The occurrence of SCH may be related to maternal immune abnormalities. SCH may increase the risk of premature rupture of membranes and abortion. However, there is no correlation between the presence or absence of SCH and neonatal outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of risk factors and pregnancy outcomes in pregnant women with subchorionic hematoma

Xu,

Lun,

Wang

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…[ 10 ] In addition, they may also be related to the following factors: abnormal coagulation function, immune and endocrine disorders, obesity, recurrent induced abortion, hypertension, and/or the use of aspirin or other anticoagulants, among which immune factors are the most closely related. [ 11 , 12 ] The patient in this case had 3 induced abortions and used aspirin enteric coated tablets and enoxaparin needles in the early treatment, both of which are susceptible factors for the occurrence of MTH.…”

Section: Discussionmentioning

confidence: 99%

“…Autoimmunity mainly includes anticardiolipin antibodies and antibodies β Abnormalities such as 2 glycoprotein antibodies and lupus anticoagulants: Studies have found that the titers of these 3 antibodies in MTH patients are significantly higher than those in normal pregnant patients, indicating that the presence of autoantibodies and pre thrombotic state can disrupt the stability of the mother fetal interface, leading to decidual immune vasculitis, intravascular microthrombosis, decidual vascular rupture, abnormal invasion of the trophoblast, and rebleeding after ischemia-reperfusion. [ 11 ] Experimental studies have shown that Panax notoginseng has the effects of shortening clotting time, increasing platelet production, increasing platelet aggregation, improving clotting ability, and repairing the endometrium. Endometrial tissue factor is involved in the process of uterine bleeding.…”

Section: Discussionmentioning

confidence: 99%

Sanji Peiyuan decoction combined with dydrogesterone in the treatment of massive subchorionic hematoma: A case report

Yang,

Zheng,

et al. 2023

Medicine

View full text Add to dashboard Cite

Rationale: Subchorionic Hematoma, often referred to as Bruce hematoma, can lead to serious obstetric complications such as intrauterine growth restriction and fetal death, as well as early and late pregnancy miscarriage, placental abruption, and premature rupture of membranes, posing great harm to both mother and fetus. Patient concerns: At present, Western medical treatments have not shown satisfactory results, necessitating the discovery of more effective clinical treatment methods. Diagnoses: Threatened miscarriage, Subchorionic hematoma, Iron deficiency anemia (mild). Interventions: Sanji Peiyuan decoction combined with dydrogesterone. Outcomes: Following 17 days of treatment with Sanji Peiyuan decoction and oral dydrogesterone tablets, the hematoma was no longer detectable by ultrasound. The patient experienced no symptoms such as abdominal pain, bloating, or vaginal bleeding. She successfully gave birth around her due date, with both the mother and child in good health. Lessons: The combination of Sanji Peiyuan decoction and oral dydrogesterone tablets shows promising clinical efficacy in treating Massive Subchorionic Hematomas. This method merits further clinical research.

show abstract

“…[3,[6][7][8] There are conflicting reports in the literature on the significance of SCH in early pregnancy. [7][8][9][10][11] However, the presence of SCH in pregnancy may increase the risk of miscarriages and adverse maternal and perinatal outcomes. [7][8][9][10][11] Therefore, this research aimed to determine the prevalence of AM and the relationship between AM and SCH in the Niger Delta region of Nigeria, where the study was conducted.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10][11] However, the presence of SCH in pregnancy may increase the risk of miscarriages and adverse maternal and perinatal outcomes. [7][8][9][10][11] Therefore, this research aimed to determine the prevalence of AM and the relationship between AM and SCH in the Niger Delta region of Nigeria, where the study was conducted. The sample size for this study was calculated using the formula: n = z 2 pq/d 2 [12] Where: n = minimum sample size z = normal standard deviation set at 95% confidence limit = 1.96 p = proportion of women in the target population with subchorionic haematoma, which is 50% (50% = 0.5).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Subchorionic Haematoma and Abdominal Massage in Pregnancy in the Niger Delta Region of Nigeria: A Pilot Study

Kiridi¹,

Oriji²,

Okechukwu³

et al. 2022

Ann Health Res

View full text Add to dashboard Cite

Background: Abdominal massage (AM) in pregnancy is a common practice in the Niger Delta region of Nigeria. AM may cause events such as subchorionic haematoma (SAH) and increase the risk of miscarriages and adverse maternal and perinatal outcomes. Objective: To determine the relationship between AM and SCH in the Niger Delta region of Nigeria. Methods: A cross-sectional study was conducted from January to June 2022 at the Obstetrics and Radiology Units of four health facilities in Bayelsa State, Nigeria. Consenting eligible pregnant women presenting to the antenatal clinic during the first trimester were consecutively included. An obstetric ultrasound scan was performed transabdominal. Results: Of the 403 women recruited, 241 (59.8%) were aged (20 – 29 years). The mean age was 28.02 ± 5.99 years. The mean body mass index was 23.82±4.60 kg/m2. While 170 (42.2%) had undergone AM in the first trimester of the index pregnancy, 126 (31.3%) had vaginal bleeding, and SCH occurred in 109 (27.0%) women. Women who had AM had 210 (CI: 58 – 878) times the odds of having SCH and 3.3 (CI: 2.14 – 5.15) times the odds of vaginal bleeding than women who did not have AM. Only 2 (1.8%) women with SCH did not have AM. Conclusion: There exists a strong association between the occurrence of SCH among pregnant women who have had AM. More health education is needed for women in the Niger Delta region and Nigeria to eradicate the archaic practice and improve pregnancy outcomes.

show abstract

Subchorionic hematoma and pregnancy outcomes in patients with threatened miscarriage

Cited by 9 publications

References 20 publications

Analysis of risk factors and pregnancy outcomes in pregnant women with subchorionic hematoma

Analysis of risk factors and pregnancy outcomes in pregnant women with subchorionic hematoma

Sanji Peiyuan decoction combined with dydrogesterone in the treatment of massive subchorionic hematoma: A case report

Relationship Between Subchorionic Haematoma and Abdominal Massage in Pregnancy in the Niger Delta Region of Nigeria: A Pilot Study

Contact Info

Product

Resources

About