Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats

Jiao, Kai; L, Niu; Wang, Meiqing; Dai, Juan; Yu, Shuxun; Liu, Xiaodong; Wang, Jun

doi:10.1016/j.bone.2010.09.010

Cited by 101 publications

(112 citation statements)

References 46 publications

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“…The results of the present study are consistent with these studies. In addition, the present study revealed the pathological change characterized by prominent cartilage thinning, reduced chondrocyte numbers, low proliferation, extracellular matrix degradation, and subchondral bone erosion (32,33).…”

Section: Discussionmentioning

confidence: 95%

Endoplasmic Reticulum Stress Regulates Rat Mandibular Cartilage Thinning under Compressive Mechanical Stress

Zhang

et al. 2013

Journal of Biological Chemistry

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Background: The molecular mechanisms of mechanical stress-induced cartilage thinning remain largely unknown. Results: Endoplasmic reticulum stress (ERS) was activated in chondrocytes during mechanical stress loading. ERS inhibition suppressed the apoptosis and restored the proliferation and cartilage thinning. Conclusion: ERS regulates mechanical stress-induced cartilage thinning. Significance: Our data demonstrate a novel pathological role for ERS and provide new insight into the treatment of temporomandibular joint diseases.

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Section: Discussionmentioning

confidence: 95%

Endoplasmic Reticulum Stress Regulates Rat Mandibular Cartilage Thinning under Compressive Mechanical Stress

Zhang

et al. 2013

Journal of Biological Chemistry

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“…A standard, three-step, avidin-biotin complex immunohistochemical staining protocol was carried out (Jiao et al, 2011). Briefly, decalcified sections were deparaffinized and rinsed in PBS, citrate buffer and micro-wave were used for antigen retrieval.…”

Section: Bone Histology Histochemistry and Immunohistochemistrymentioning

confidence: 99%

Environmental level of cadmium exposure stimulates osteoclasts formation in male rats

Chen

Wang

Xu-fang

et al. 2013

Food and Chemical Toxicology

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“…1) [40]. Changes in the mechanical integrity of the articular cartilage will affect how joint loads are distributed, and initiate remodeling responses in the underlying bone [41]. In patients with OA, bone remodeling often results in the formation of less mineralized bone, which is more prone to deformation when loaded [42].…”

Section: Biomechanical Interactions Between Bone and Cartilage In Oamentioning

confidence: 99%

Mechanical Loading: Bone Remodeling and Cartilage Maintenance

Yokota

Leong

Sun

2011

Curr Osteoporos Rep

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Bone remodeling and cartilage maintenance are strongly influenced by biomechanical signals generated by mechanical loading. Although moderate loading is required to maintain bone mass and cartilage homeostasis, loading can cause deleterious effects such as bone fracture and cartilage degradation. Because a tight coupling exists between cartilage and bone, alterations in one tissue can affect the other. Bone marrow lesions are often associated with an increased risk of developing cartilage defects, and changes in the articular cartilage integrity are linked to remodeling responses in the underlying bone. Although mechanisms regulating the maintenance of these two tissues are different, compelling evidence indicates that the signal pathways crosstalk, particularly with the Wnt pathway. A better understanding of the complex tempero-spatial interplay between bone remodeling and cartilage degeneration will help develop a therapeutic loading strategy that prevents bone loss and cartilage degeneration.

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Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats

Cited by 101 publications

References 46 publications

Endoplasmic Reticulum Stress Regulates Rat Mandibular Cartilage Thinning under Compressive Mechanical Stress

Endoplasmic Reticulum Stress Regulates Rat Mandibular Cartilage Thinning under Compressive Mechanical Stress

Environmental level of cadmium exposure stimulates osteoclasts formation in male rats

Mechanical Loading: Bone Remodeling and Cartilage Maintenance

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