Subchondral bone-inspired hydrogel scaffold for cartilage regeneration

Guo, Chuan; Cao, Zhenxing; Peng, Yan; Wu, Rui; Xu, Huibin; Yuan, Zhaoyang; Hui, Xiong; Wang, Yu; Wu, Ye; Li, Weilong; Kong, Qingquan; Wang, Yi; Wu, Jinrong

doi:10.1016/j.colsurfb.2022.112721

Cited by 14 publications

(9 citation statements)

References 67 publications

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“…The healing of subchondral bone defects predominantly involves cartilage formation, requiring the involvement of a higher number of cells and intricate extracellular matrix composition in comparison to cranial defects. [ 61 ] These findings demonstrate that CDC20@ZIF‐8@eM‐Apt possesses outstanding bone regeneration capabilities across two different animal models, illustrating the biocompatibility and potent osteogenic efficacy.…”

Section: Resultsmentioning

confidence: 84%

Enhancing Bone Regeneration through CDC20‐Loaded ZIF‐8 Nanoparticles Wrapped in Erythrocyte Membranes with Targeting Aptamer

Du,

Deng,

Cheng

et al. 2023

Adv Healthcare Materials

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In the context of bone regeneration, nanoparticles harboring osteogenic factors have emerged as pivotal agents for modulating the differentiation fate of stem cells. However, persistent challenges surrounding biocompatibility, loading efficiency, and precise targeting ability warrant innovative solution. In this study, a novel nanoparticle platform founded upon the zeolitic imidazolate framework‐8 (ZIF‐8) is introduced. This new design, CDC20@ZIF‐8@eM‐Apt, involves the envelopment of ZIF‐8 within an erythrocyte membrane (eM) cloak, and is coupled with a targeting aptamer. ZIF‐8, distinguished by its porosity, biocompatibility, and robust cargo transport capabilities, constitutes the core framework. Cell division cycle protein 20 homolog (CDC20) is illuminated as a new target in bone regeneration. The eM plays a dual role in maintaining nanoparticle stability and facilitating fusion with target cell membranes, while the aptamer orchestrates the specific recruitment of bone marrow mesenchymal stem cells (BMSCs) within bone defect sites. Significantly, CDC20@ZIF‐8@eM‐Apt amplifies osteogenic differentiation of BMSCs via the inhibition of NF‐κB p65, and concurrently catalyzes bone regeneration in two bone defect models. Consequently, CDC20@ZIF‐8@eM‐Apt introduces a pioneering strategy for tackling bone defects and associated maladies, opening novel avenues in therapeutic intervention.

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Section: Resultsmentioning

confidence: 84%

Enhancing Bone Regeneration through CDC20‐Loaded ZIF‐8 Nanoparticles Wrapped in Erythrocyte Membranes with Targeting Aptamer

Du,

Deng,

Cheng

et al. 2023

Adv Healthcare Materials

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“…In summary, this subchondral bone-like hydrogel represents a promising advancement in the field of cartilage regeneration and holds great potential for various applications in bioremediation and tissue repair. 133…”

Section: Osteochondral Repair and Regeneration Of Tmj With Hydrogels ...mentioning

confidence: 99%

Applications of hydrogels in tissue-engineered repairing of temporomandibular joint diseases

Wang,

Liu,

Wang

et al. 2024

Biomater. Sci.

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“…Further, the injection of the cryogel into a canine model resulted in osteochondral regeneration both in the absence and presence of adipose-derived stem cells, meaning that this hydrogel composition can enhance the repair of osteochondral injuries on its own [ 58 ]. Guo and colleagues designed a hydrogel scaffold that mimics microstructures within subchondral lamellar bone via the condensation of cross-linking between chitosan and nontoxic citric acid and ensuing microchannels formation by lyophilization [ 59 ]. This novel hydrogel structure supported infiltration, adhesion, proliferation, migration, and chondrogenic differentiation of BM-MSCs in vitro [ 59 ].…”

Section: Bone Cartilage and Dental Tissuesmentioning

confidence: 99%

“…Guo and colleagues designed a hydrogel scaffold that mimics microstructures within subchondral lamellar bone via the condensation of cross-linking between chitosan and nontoxic citric acid and ensuing microchannels formation by lyophilization [ 59 ]. This novel hydrogel structure supported infiltration, adhesion, proliferation, migration, and chondrogenic differentiation of BM-MSCs in vitro [ 59 ]. Rajagopal and colleagues determined that rabbit BM-MSCs deposited more glycosaminoglycans and DNA on multi-layered chitosan-gelatin scaffolds than on randomly aligned ones, amounting to thicker cartilage formation [ 60 ].…”

Section: Bone Cartilage and Dental Tissuesmentioning

confidence: 99%

Chitosan-Based Biomaterials for Tissue Regeneration

et al. 2023

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Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It has numerous qualities that make it attractive for biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, and many others. Importantly, chitosan can be fabricated into a variety of structures including nanoparticles, scaffolds, hydrogels, and membranes, which can be tailored to deliver a desirable outcome. Composite chitosan-based biomaterials have been demonstrated to stimulate in vivo regeneration and the repair of various tissues and organs, including but not limited to, bone, cartilage, dental, skin, nerve, cardiac, and other tissues. Specifically, de novo tissue formation, resident stem cell differentiation, and extracellular matrix reconstruction were observed in multiple preclinical models of different tissue injuries upon treatment with chitosan-based formulations. Moreover, chitosan structures have been proven to be efficient carriers for medications, genes, and bioactive compounds since they can maintain the sustained release of these therapeutics. In this review, we discuss the most recently published applications of chitosan-based biomaterials for different tissue and organ regeneration as well as the delivery of various therapeutics.

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Subchondral bone-inspired hydrogel scaffold for cartilage regeneration

Cited by 14 publications

References 67 publications

Enhancing Bone Regeneration through CDC20‐Loaded ZIF‐8 Nanoparticles Wrapped in Erythrocyte Membranes with Targeting Aptamer

Enhancing Bone Regeneration through CDC20‐Loaded ZIF‐8 Nanoparticles Wrapped in Erythrocyte Membranes with Targeting Aptamer

Applications of hydrogels in tissue-engineered repairing of temporomandibular joint diseases

Chitosan-Based Biomaterials for Tissue Regeneration

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