Subchondral bone circulation in osteoarthritis of the human knee

Aaron, Roy K.; Racine, Jennifer; Voisinet, Anne; Evangelista, Peter; Dyke, Jonathan P.

doi:10.1016/j.joca.2018.04.003

Cited by 31 publications

(26 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The authors' clinical trajectories are consistent with Lee et al's fluid model of osteoarthritis [6] and Aaron et al's report of subchondral bone circulation in knee OA [7], both based on dynamic contrast-enhanced MRI findings. As an extension of these models, our clinical model of knee osteoarthritis progression (Fig.…”

Section: Proposed Clinical Modelsupporting

confidence: 84%

“…The search yielded 135 articles (Supplementary Appendix) of which 113 were excluded by title, abstract, or full-text review for the following reasons: study of a medical treatment, surgical study, or procedure (23), bone density or mechanical properties of bone or cartilage (19), specific patient or animal subgroup (12), posttraumatic osteoarthritis (6), or receptors, hormones, or biological markers (6); interventional study (14); test of imaging technique (7); histological or morphometric study (5); review article (14) or letter (1); non-English language (6). Twenty-two articles were eligible, of which 13 [6][7][8][9][10][11][12][13][14][15][16][17][18] were cited because they had the highest relevance to inform the proposed clinical model (Fig. 2).…”

Section: Literature Searchmentioning

confidence: 99%

“…Lee et al hypothesized that changes in perfusion patterns in subchondral bone bear a functional relationship to bone remodeling and cartilage degeneration [6]. Both Lee and Aaron emphasized venous outflow obstruction as a key mechanism of disease, where venous stasis can affect intraosseous pressure, can reduce arterial inflow, can reduce oxygen content, and may contribute to altered cell signaling in the pathophysiology of OA [7]. As described above, we incorporated these fluid dynamics as the core principles in our clinical model.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Gourlay

2020

Clin Rheumatol

View full text Add to dashboard Cite

Because the pathophysiology of knee osteoarthritis is poorly understood, optimal evidence-based clinical management is uncertain. Sibling comparison studies can help inform a clinical model to guide preventive care. We compared the 8-year clinical outcomes in 2 sisters with a family history of osteoarthritis, normal BMI, and absence of knee pain at baseline. Both patients had Kellgren–Lawrence grade 1 in the affected knee at the time of twisting knee injuries leading to osteoarthritis diagnoses at age 50 (patient 1) and 51 (patient 2). Patient 1 developed a chronic right knee effusion, and progressed to Kellgren–Lawrence grade 3 bilaterally by the time she had a right total knee replacement at age 58. Patient 2 had subchondral fractures of the right knee with transient effusion, which healed after 1 year of partial weight-bearing with crutches and subsequent daily use of knee sleeves. Patient 2 had Kellgren–Lawrence grade 0 bilaterally upon surveillance imaging at age 58. The terms “osteoarthritis and knee and diagnostic imaging and subchondral bone and pathophysiology” were searched in the PubMed database to identify original research articles to inform a clinical model consistent with the patients’ outcomes. A fluid model of osteoarthritis was the best explanatory model for the discordant clinical trajectories of the age-matched siblings. Patient recommendations are presented based on these findings.

show abstract

Section: Proposed Clinical Modelsupporting

confidence: 84%

Section: Literature Searchmentioning

confidence: 99%

Section: Comparison With Other Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Gourlay

2020

Clin Rheumatol

View full text Add to dashboard Cite

show abstract

“…However, in this longitudinal study we could demonstrate that BMLs act merely as effect modifier of, and just happen to be correlated with, change in synovitis and osteophytes. To more precisely characterize the role of the subchondral bone in OAbeyond the presence of BMLsdynamic contrast-enhanced MR imaging could be used in future studies 37,38 .…”

Section: Table IIImentioning

confidence: 99%

In finger osteoarthritis, change in synovitis is associated with change in pain on a joint-level; a longitudinal magnetic resonance imaging study

Beest

Damman

Liu

et al. 2019

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Objective: To investigate determinants of decrease and increase in joint pain in symptomatic finger osteoarthritis (OA) on magnetic resonance (MR) imaging over 2 years. Design: Eighty-five patients (81.2% women, mean age 59.2 years) with primary hand OA (89.4% fulfilling American College of Rheumatology (ACR) classification criteria) from a rheumatology outpatient clinic received contrast-enhanced MR imaging (1.5T) and physical examination of the right interphalangeal finger joints 2e5 at baseline and at follow-up 2 years later. MR images were scored paired in unknown time order, following the Hand OA MRI scoring system (HOAMRIS). Joint pain upon palpation was assessed by research nurses. Odds ratios (ORs; 95% confidence intervals) were estimated on joint level (n ¼ 680), using generalized estimating equations (GEE) to account for the within patient effects. Additional adjustments were made for change in MR-defined osteophytes, synovitis, and bone marrow lesions (BMLs). Results: Of 116 painful joints at baseline, at follow-up: 76 had less pain, 21 less synovitis, and 13 less BMLs. A decrease in synovitis (OR ¼ 5.9; 1.12e31.0), but not in BMLs (OR ¼ 0.39; 0.10e1.50), was associated with less pain. Of 678 joints without maximum baseline pain, at follow-up: 115 had increased pain, 132 increased synovitis, 96 increased BMLs, and 44 increased osteophytes. Increased synovitis (OR ¼ 1.81; 1.11e2.94), osteophytes (OR ¼ 2.75; 1.59e4.8), but not BMLs (OR ¼ 1.14; 0.81e1.60), was associated with increased pain. Through stratification it became apparent that BMLs were mainly acting as effect modifier of the synovitisepain association. Conclusion: Decrease in MR-defined synovitis is associated with reduced joint pain, identifying synovitis as a possible target for treatment of finger OA.

show abstract

“…As a complex disease, the occurrence and development of OA involves changes to the mRNA (Steinberg et al, 2017). The blood flow under the subchondral bone (Aaron et al, 2018) may carry the signal of OA (Fotouhi et al, 2018). It can be detected when the mRNA level changes in blood (Budd et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Identification and Analysis of Blood Gene Expression Signature for Osteoarthritis With Advanced Feature Selection Methods

Lan

Kong

et al. 2018

Front. Genet.

View full text Add to dashboard Cite

Osteoarthritis (OA) is a complex disease that affects articular joints and may cause disability. The incidence of OA is extremely high. Most elderly people have the symptoms of osteoarthritis. The physiotherapy of OA is time consuming, and the chances of full recovery from OA are very minimal. The most effective way of fighting OA is early diagnosis and early intervention. Liquid biopsy has become a popular noninvasive test. To find the blood gene expression signature for OA, we reanalyzed the publicly available blood gene expression profiles of 106 patients with OA and 33 control samples using an automatic computational pipeline based on advanced feature selection methods. Finally, a compact 23-gene set was identified. On the basis of these 23 genes, we constructed a Support Vector Machine (SVM) classifier and evaluated it with leave-one-out cross-validation. Its sensitivity (Sn), specificity (Sp), accuracy (ACC), and Mathew's correlation coefficient (MCC) were 0.991, 0.909, 0.971, and 0.920, respectively. Obviously, the performance needed to be validated in an independent large dataset, but the in-depth biological analysis of the 23 biomarkers showed great promise and suggested that mRNA surveillance pathway and multicellular organism growth played important roles in OA. Our results shed light on OA diagnosis through liquid biopsy.

show abstract

Subchondral bone circulation in osteoarthritis of the human knee

Cited by 31 publications

References 15 publications

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

In finger osteoarthritis, change in synovitis is associated with change in pain on a joint-level; a longitudinal magnetic resonance imaging study

Identification and Analysis of Blood Gene Expression Signature for Osteoarthritis With Advanced Feature Selection Methods

Contact Info

Product

Resources

About