Subchondral bone changes after joint distraction treatment for end stage knee osteoarthritis

Mastbergen, S.C.; Ooms, A.; Turmezei, Tom; Mackay, James; Heerwaarden, Ronald J van; Spruijt, S.; Lafeber, Floris P. J. G.; Jansen, M.

doi:10.1016/j.joca.2021.12.014

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…6 Knee osteoarthritis is a chronic progressive joint disorder involving the joint pain, swelling, deformity, muscle atrophy, and synovium, and tends to occur in middle-aged and elderly people; it is the most common kind of disabling arthritis. 12 Typical pathological modifications in OA include articular cartilage damage, abnormal subchondral bone remodeling and muscle loss. 13 Therefore, preventing joint destruction is essential for OA therapy.…”

Section: Discussionmentioning

confidence: 99%

Total Glucosides of Peony Alleviate Joint Destruction in Rabbits With Osteoarthritis

Chao Wei,

Yi Shan,

Fei Yue

et al. 2023

Natural Product Communications

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Objective Although many painkillers can be used to relieve the symptoms of osteoarthritis (OA), these drugs do not address joint bone degeneration and muscle wasting, highlighting the need for alternative treatments. This study evaluated the ability of various plant extracts to inhibit joint destruction, focusing on the total glucosides of peony (TGP) obtained from the normal Chinese medication white peony. Methods A rabbit OA model was established by anterior cruciate ligament resection (ACLT) and TGP treatment was initiated for 3 months. The morphologies of the skeletal muscle fibers, articular cartilage, and subchondral bone of the knee joint were histologically observed via X-ray and micro-computed tomography scan. Results TGP significantly reduced the histopathological changes associated with skeletal muscle atrophy and inflammation, and alleviated cartilage degeneration. In addition, TGP treatment significantly improved the bone density and microstructure of subchondral bone in rabbit knee joints compared with the model group. Conclusion The results suggested that TGP treatment may alleviate the progression of osteoarthritis and reduce the destruction of joint cartilage and bone in ACLT.

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Section: Discussionmentioning

confidence: 99%

Total Glucosides of Peony Alleviate Joint Destruction in Rabbits With Osteoarthritis

Chao Wei,

Yi Shan,

Fei Yue

et al. 2023

Natural Product Communications

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“…OA is a degenerative disease characterized by progressive cartilage loss and bone deterioration [ 86 ], whereas RA is a systemic, persistent inflammatory condition driven by an autoimmune response to stimuli in the environment mainly affecting the synovial joints [ 87 ]. Rapid loss of articular cartilage, degradation of collagen and proteoglycans, upregulation of matrix metalloproteinases—leukotrienes (particularly leukotriene B4)—and thickening of the subchondral plate are the main contributors to the OA and RA [ 88 , 89 , 90 , 91 , 92 , 93 , 94 ]. A study by Yamada et al reported that MMP-1, MMP-3, matrix degradation, and IL-1α-induced release of proteoglycans in cartilages of osteoarthritic rats was inhibited with esculetin treatment (10–100 µM) [ 95 ].…”

Section: Therapeutic Applications Of Esculetinmentioning

confidence: 99%

Pharmacological and Therapeutic Applications of Esculetin

Garg

Gupta

Sahu

et al. 2022

IJMS

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Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, etc. Free radicals lead to the development of oxidative stress causing inflammation, arthritis, cancer, diabetes, fatty liver disease, etc. These further reduce the efficacy of anticancer drugs, activate inflammatory signaling pathways, degrade joints and cartilage, and disrupt the glycemic index and normal function of liver enzymes. For instance, the current treatment modalities used in arthritis such as non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatoid drugs, and lipoxygenase inhibitors present limited efficacy and adverse effects. Thus, there is a constant need to find newer and safer alternatives. Esculetin has an immense antioxidative potential thereby alleviating arthritis, diabetes, malignancies, and hepatic disorders. Structurally, esculetin contains two hydroxyl groups, which enhance its ability to function as an antioxidant by inhibiting oxidative stress in pathological conditions. Leukotriene B4 synthesis, NF-κB and MPAK pathway activation, and inflammatory cytokine production are the main causes of bone and joint deterioration in arthritis, whereas esculetin treatment reverses these factors and relieves the disease condition. In contrast, lipid peroxidation caused by upregulation of TGF-β-mediated expression and dysfunction of antioxidant enzymes is inhibited by esculetin therapy, thus reducing liver fibrosis by acting on the PI3K/FoxO1 pathway. Therefore, targeting NF-κB, pro-inflammatory cytokines, TGF-β and oxidative stress may be a therapeutic strategy to alleviate arthritis and liver fibrosis.

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“…OA is a degenerative disease characterized by progressive cartilage loss and bone deterioration [64] whereas rheumatoid arthritis is a systemic, persistent inflammatory condition driven by an autoimmune response to stimuli in the environment mainly affecting the synovial joints [65]. Rapid loss of articular cartilage, degradation of collagen and proteoglycans, upregulation of matrix metalloproteinases, leukotrienes (particularly leukotriene B4), and thickening of the subchondral plate are the main contributors to the OA and RA [66][67][68][69][70][71][72]. Various studies have reported that esculetin acts on cartilage and results in the inhibition of matrix degradation by suppressing the MMP production, secretion, and its activity in rabbit joint cartilage, which serves as a lead therapeutic compound in the treatment of OA and RA [73,74].…”

Section: Esculetin In Arthritismentioning

confidence: 99%

Mechanistic insights into the biochemical and pharmacological profile of esculetin

Garg¹,

Gupta²,

Sahu³

et al. 2022

Preprint

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Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, and many others. Glycosides and caffeic acid conjugates are the common forms of esculetin present in medicinal plants. Esculetin acts as an antioxidant, anti-inflammatory, anti-diabetic, anti-hepatic, and anti-cancer agent by inhibiting the production of free radicals, inflammatory mediators, and genes that cause liver diseases and cancer. It also aids in the regulation of blood sugar. Scientists developing pharmaceutical formulations require some rationale and preliminary studies for drug design, but a small number of clinical studies on humans containing esculetin limit its potential for use as a safe alternative drug. Therefore, in this review article, the published studies have been reviewed to identify the pathogenesis of cancer, oxidative stress, inflammation, arthritis, diabetes and fatty liver along with the discussion on potential therapeutic strategies of esculetin. Advancements in our understanding of these diseases will aid in the development of new and innovative medications for treating many ailments. In conclusion, esculetin has immense potential to be used as a safe drug against many diseases but requires further testing and confirmation through clinical trials.

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Subchondral bone changes after joint distraction treatment for end stage knee osteoarthritis

Cited by 13 publications

References 26 publications

Total Glucosides of Peony Alleviate Joint Destruction in Rabbits With Osteoarthritis

Total Glucosides of Peony Alleviate Joint Destruction in Rabbits With Osteoarthritis

Pharmacological and Therapeutic Applications of Esculetin

Mechanistic insights into the biochemical and pharmacological profile of esculetin

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