2013
DOI: 10.2967/jnmt.112.117234
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Subcentimeter Tumor Lesion Delineation for High-Resolution 18F-FDG PET Images: Optimizing Correction for Partial-Volume Effects

Abstract: In PET, partial-volume effects cause errors in estimation of size and activity for small objects with radiopharmaceutical uptake. Recent methods for image reconstruction, compared with traditional reconstruction techniques, include algorithms for resolution recovery that result in images with higher resolution and enable quantification of size and activity of smaller objects. The purpose of this study was to evaluate a combination of 2 algorithms for volume delineation and partial-volume correction on uptake v… Show more

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Cited by 24 publications
(26 citation statements)
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“…PET scanners with "resolution-recovery" algorithms have become available. These algorithms usually account for all resolution-degrading effects and are typically based on measurements of pointlike sources for the determination of point-spread functions (Mourik et al 2010;Narayanan and Perkins 2013;Wallsten et al 2013). This is a simple and effective approach when only one isotope is to be used (e.g., 18 F) or when the contribution of the positron range is small compared to the other effects.…”
Section: Discussionmentioning
confidence: 99%
“…PET scanners with "resolution-recovery" algorithms have become available. These algorithms usually account for all resolution-degrading effects and are typically based on measurements of pointlike sources for the determination of point-spread functions (Mourik et al 2010;Narayanan and Perkins 2013;Wallsten et al 2013). This is a simple and effective approach when only one isotope is to be used (e.g., 18 F) or when the contribution of the positron range is small compared to the other effects.…”
Section: Discussionmentioning
confidence: 99%
“…Clinical repeatability data consisted of an 18 F-FDG PET/CT study (28) on 11 patients with advanced non-small cell lung cancer and an 18 Ffluoromethylcholine PET/CT study (29) on 12 patients with metastatic prostate cancer. At the time the patients underwent PET, they received no treatment.…”
Section: Clinical Datamentioning
confidence: 99%
“…They fasted for 6 and 4 h before undergoing 18 F-FDG and 18 F-fluoromethylcholine PET, respectively. PET/CT scans were acquired at 60 and 40 min after injection of 185 MBq of 18 F-FDG and 200 MBq of 18 F-fluoromethylcholine, respectively. Images were reconstructed using ordered-subset time-of-flight iterative reconstruction with 3 iterations and 33 subsets, with and without resolution modeling.…”
Section: Clinical Datamentioning
confidence: 99%
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