Subcellular Muscle Studies in the Prune Belly Syndrome

Mininberg, David T.; Montoya, F; Okada, Kiyoki; Galioto, Frank M.; Presutti, R. John

doi:10.1016/s0022-5347(17)60470-1

Cited by 39 publications

(9 citation statements)

References 7 publications

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“…Pinto et al (1982) suggest that muscle necrosis or fibrosis within the anterior abdominal muscle is a result of ischemia due to venous obstruction following raised intra-abdominal pressure. However, the muscle fibers in the prune-belly syndrome are either absent or of the "embryonal type", broadened, not striated, with loss of coherence in Z bands and mitochondria1 abnormalities on electron microscopic studies (Nunn and Stephens, 1961;Mininberg et al, 1973). In the present cases, there was no muscular degeneration nor necrosis of the abdominal walls, although electron microscopic examination was not performed.…”

Section: *: No Information Was Availablecontrasting

confidence: 45%

“…As to the pathogenesis of a prune-like abdomen whlch is one of the principal anomalies of this syndrome, several hypotheses have been proposed, i.e., (1) primary mesodermal errors (Lattimmer, 1958;Nunn and Stephens, 1961;Mininberg et al, 1973;Duckett, 1980;Straub and Spranger, 1980), ( 2 ) primary urinary tract abnormalities (Silvermann and Huang, 1950;Pagon et al, 1979;Monie and Monie, 1979, Lubinsky, 1980, Pinto et al, 1982, (3) raised intraabdominal pressure (Potter and or absence (-) of anomaly otherwise stated. Craig, 1975;Pinto et al, 1982) and (4) transient hydrops of abdominal wall in the fetal period (Lubinsky and Rapoport, 1983).…”

Section: Discussionmentioning

confidence: 99%

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Prune Belly Syndrome: Report of Twelve Autopsy Cases and Possible Pathogenesis

Kawamoto

Ikeda

Matsuo

et al. 1985

Congenital Anomalies

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Twelve autopsy cases (9 males, 3 females) of the prune belly syndrome are presented. Principal anomalies of this syndrome are a prune‐like abdominal feature and a giant bladder. Urethral atresia was observed in most but two cases. Imperforate anus and rectovesical fistula were observed in 8 and 7 cases respectively. Associated anomalies were those which may or may not be embryologically related to the principal anomalies. As regards the pathogenesis, the authors propose that a primary defect may occur during any developmental stage of the somitic mesoderm, genital tubercle and urethra. In conclusion, the prune belly syndrome may be of spectrum anomalies depending on the stage specificity mainly in the abdominal wall and genito‐urinary organs.

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Section: *: No Information Was Availablecontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Prune Belly Syndrome: Report of Twelve Autopsy Cases and Possible Pathogenesis

Kawamoto

Ikeda

Matsuo

et al. 1985

Congenital Anomalies

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“…In all cases, the oblique and transverse abdominal muscles were the most affected muscles, with normality or relative sparing of the recti abdominis, resulting in lateral bulging of the abdomen. This anatomical presentation is quite different from PBS, in which the most affected muscles are typically the medial and inferior ones (Mininberg et al 1973). Furthermore, PBS is typically characterized by wrinkled redundant skin on the abdomen, a feature not evident in the aforementioned cases.…”

Section: Discussionmentioning

confidence: 83%

Isolated hypoplasia of abdominal wall muscles associated with fetal ascites

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Cont

Brovedani

et al. 2016

Congenital Anomalies

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We report the case of an infant born after parvovirus B19-induced fetal hydrops, who presented at birth with bilateral abdominal wall laxity, which was more evident on the flanks. Imaging exams revealed congenital hypoplasia of oblique abdominal muscles not associated with other anatomical abnormalities except for small liver calcifications. We review the medical literature and identify similar cases associated with fetal ascites. We propose that isolated hypoplasia of abdominal wall muscles can be associated with fetal ascites from various causes, and represents a separate condition from prune belly syndrome.

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“…Although undoubtedly all four of our cases had a posterior urethral valve, proof of the coexistence of the prune belly syndrome is a much more difficult matter as there is no absolute marker of this condition. Histologically the muscle of the abdominal wall may be embryonic in type (O'Kell, 1969), whilst on electron microscopy Z band disorganisation and large glycogen aggregates may be found (Mininberg et al, 1973), but these findings are not constant. Biopsy of the wall of the ureters and bladder may be more rewarding.…”

Section: Discussionmentioning

confidence: 99%