Subcellular localizations of Arabidopsis myotubularins MTM1 and MTM2 suggest possible functions in vesicular trafficking between ER and cis-Golgi

Nagpal, Akanksha; Ndamukong, Ivan; Hassan, Ammar; Avramova, Zoya; Baluška, Frantǐsek

doi:10.1016/j.jplph.2016.06.001

Cited by 3 publications

(3 citation statements)

References 74 publications

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“…For example, in metazoans it has been shown that the phosphatase SAC1 shuttles between the ER and the cis -Golgi and controls the membrane levels of phosphatidylinositol 4-phosphate/phosphatidylinositol phosphate (PtdIns4P/PtdInsP), which has an effect on membrane traffic in response to growth factor signaling [135, 136]. A recent study of Arabidopsis myotubularins (MTMs), which are 3′-phosphatases that dephosphorylate the lipids PtdIns3 P and PtdIns3,5P2 and generate PtdIns5 P [137, 138], has shown that AtMTM1 localizes at the cis -Golgi, while AtMTM2-GFP is distributed at the ER [139]. The interesting hypothesis has been put forward that AtMTM1and AtMTM2 may coordinate the levels of PtdIns5 P and of PtdIns3P/PtdInsP on the cis -Golgi and the ERES, respectively [139].…”

Section: Plant Eres Are Tunablementioning

confidence: 99%

“…A recent study of Arabidopsis myotubularins (MTMs), which are 3′-phosphatases that dephosphorylate the lipids PtdIns3 P and PtdIns3,5P2 and generate PtdIns5 P [137, 138], has shown that AtMTM1 localizes at the cis -Golgi, while AtMTM2-GFP is distributed at the ER [139]. The interesting hypothesis has been put forward that AtMTM1and AtMTM2 may coordinate the levels of PtdIns5 P and of PtdIns3P/PtdInsP on the cis -Golgi and the ERES, respectively [139]. As PtdInsP isomers have been implicated in the generation of membrane subdomains that respond to signaling clues [138], the function of these proteins in the early secretory pathway may have a bearing on the differentiation of ERES in plant cells.…”

Section: Plant Eres Are Tunablementioning

confidence: 99%

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Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?

Brandizzí

2018

Seminars in Cell & Developmental Biology

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The biogenesis of about one third of the cellular proteome is initiated in the endoplasmic reticulum (ER), which exports proteins to the Golgi apparatus for sorting to their final destination. Notwithstanding the close proximity of the ER with other secretory membranes (e.g., endosomes, plasma membrane), the ER is also important for the homeostasis of non-secretory organelles such as mitochondria, peroxisomes, and chloroplasts. While how the plant ER interacts with most of the non-secretory membranes is largely unknown, the knowledge on the mechanisms for ER-to-Golgi transport is relatively more advanced. Indeed, over the last fifteen years or so, a large number of exciting results have contributed to draw parallels with non-plant species but also to highlight the complexity of the plant ER-Golgi interface, which bears unique features. This review reports and discusses results on plant ER-to-Golgi traffic, focusing mainly on research on COPII-mediated transport in the model species Arabidopsis thaliana.

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Section: Plant Eres Are Tunablementioning

confidence: 99%

Section: Plant Eres Are Tunablementioning

confidence: 99%

Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?

Brandizzí

2018

Seminars in Cell & Developmental Biology

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“…PI5P synthesis is possible via two pathways: either via PIKfyve kinase from PI or via myotubularin phosphatase from phosphatidylinositol-3,5-diphosphate [PI(3,5)P 2 ]. Both pathways are possible in plants as PIKfyve kinase and myotubularin phosphatases are present in Arabidopsis [ 47 , 48 ]. Arabidopsis myotubularins AtMTM1 and AtMTM2 control vesicular trafficking between the ER and cis -Golgi [ 48 ], and AtMTM1 controls PI5P levels associated with ROS–ABA-mediated stomatal movements [ 49 ].…”

Section: Contribution Of Signaling Phosphoinositides and The Cytoskelmentioning

confidence: 99%

Understanding and exploiting autophagy signaling in plants

Batoko

Dagdas

Baluška

et al. 2017

Essays in Biochemistry

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Autophagy is an essential catabolic pathway and is activated by various endogenous and exogenous stimuli. In particular, autophagy is required to allow sessile organisms such as plants to cope with biotic or abiotic stress conditions. It is thought that these various environmental signaling pathways are somehow integrated with autophagy signaling. However, the molecular mechanisms of plant autophagy signaling are not well understood, leaving a big gap of knowledge as a barrier to being able to manipulate this important pathway to improve plant growth and development. In this review, we discuss possible regulatory mechanisms at the core of plant autophagy signaling.

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Myotubularins, PtdIns5P, and ROS in ABA-mediated stomatal movements in dehydrated Arabidopsis seedlings

Nagpal

Hassan

Ndamukong

et al. 2018

Functional Plant Biol.

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Myotubularins (MTMs) are lipid phosphoinositide 3-phosphate phosphatases and the product of their enzyme activity – phosphoinositide 5-phosphate (PtdIns5P) – functions as a signalling molecule in pathways involved in membrane dynamics and cell signalling. Two Arabidopsis genes, AtMTM1 and AtMTM2, encode enzymatically active phosphatases but although AtMTM1 deficiency results in increased tolerance to dehydration stress and a decrease in cellular PtdIns5P, the role of AtMTM2 is less clear, as it does not contribute to the PtdIns5P pool upon dehydration stress. Here we analysed the involvement of AtMTM1, AtMTM2 and PtdIns5P in the response of Arabidopsis seedlings to dehydration stress/ABA, and found that both AtMTM1 and AtMTM2 were involved but affected oppositely stomata movement and the accumulation of reactive oxygen species (ROS, e.g. H2O2). Acting as a secondary messenger in the ABA-induced ROS production in guard cells, PtdIns5P emerges as an evolutionarily conserved signalling molecule that calibrates cellular ROS under stress. We propose the biological relevance of the counteracting AtMTM1 and AtMTM2 activities is to balance the ABA-induced ROS accumulation and cellular homeostasis under dehydration stress.

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Subcellular localizations of Arabidopsis myotubularins MTM1 and MTM2 suggest possible functions in vesicular trafficking between ER and cis-Golgi

Cited by 3 publications

References 74 publications

Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?

Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?

Understanding and exploiting autophagy signaling in plants

Myotubularins, PtdIns5P, and ROS in ABA-mediated stomatal movements in dehydrated Arabidopsis seedlings

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