“…Although extensively studied, the site of mT membrane localization remains unresolved with morphologic studies favouring intracellular membranes (Dilworth et al, 1986;Templeton et al, 1984;Zhu et al, 1984) while biochemical analyses continue to be interpreted as suggesting that kinase active mT containing complexes are located at the plasma membrane (Ballmer-Hofer and Benjamin, 1985;Ito et al, 1977;Scha hausen et al, 1982;Segawa and Ito, 1982). Recently, we have demonstrated a role for cytoskeletal proteins, particularly actin, in the localization of mT (Andrews et al, 1993).…”