Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14

Wang, Qing; McEwen, Donald G.; Ornitz, David M.

doi:10.1016/s0925-4773(99)00241-5

Cited by 85 publications

(87 citation statements)

References 7 publications

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“…Nuclear localization is mediated by a bipartite translocation signal sequence located in the amino-terminal region unique to the "a" isoform (Smallwood et al, 1996). By contrast, "b" isoforms of FHFs expressed following transfection are almost exclusively cytoplasmic in distribution (Wang et al, 2000). The subcellular distribution of endogenous neuronal FHF2 isoforms, as studied on Western blots of fractionated tissues, does not readily comply with observations made on transfected cells.…”

Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 82%

“…FHF expression commences during embryogenesis after the emergence of postmitotic neurons and continues into adulthood Munoz-Sanjuan et al, 1999;Smallwood et al, 1996;Wang et al, 2002;Wang et al, 2000). Expression is almost exclusively in neuronal cells, although Schwann cells also express FHF2 RNA (C. Pardee and M. Goldfarb, unpublished data).…”

Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 99%

“…Each FHF gene is expressed in a distinct subset of neurons in the central and peripheral nervous systems, so that different types of neurons have distinguishing FHF expression profiles, some of which are listed in Table 1. Certain neurons have been shown to preferentially express one splice isoform of FHF RNA over another (Munoz-Sanjuan et al, 2000b;Wang et al, 2000).…”

Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 99%

“…When expression vectors for FHF1a, FHF2a, or FHF4a are transfected into cultured cells, the proteins are predominantly nuclear in distribution (Smallwood et al, 1996;Wang et al, 2000). Nuclear localization is mediated by a bipartite translocation signal sequence located in the amino-terminal region unique to the "a" isoform (Smallwood et al, 1996).…”

Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 99%

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Fibroblast growth factor homologous factors: Evolution, structure, and function

Goldfarb¹

2005

Cytokine & Growth Factor Reviews

185

170

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SummaryFibroblast growth factor homologous factors (FHFs) bear strong sequence and structural similarity to fibroblast growth factors (FGFs). However, the biochemical and functional properties of FHFs are largely, if not totally, unrelated to those of FGFs. Whereas FGFs function through binding to the extracellular domains of FGF receptors (FGFRs), FHFs bind to intracellular domains of voltage-gated sodium channels (VGSCs) and to a neuronal MAP kinase scaffold protein, isletbrain-2 (IB2). These findings demonstrate the remarkable functional adaptability during evolution of the FGF gene family. FHF gene mutations in mice result in a range of neurological abnormalities, and at least one of these anomalies, cerebellar ataxia, is linked to FHF mutations in humans. This article reviews the sequences and structure of FHFs, along with our still limited understanding of FHF function.

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Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 82%

Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 99%

Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 99%

Section: Vertebrate Fhf Gene Expression and Protein Distributionmentioning

confidence: 99%

See 2 more Smart Citations

Fibroblast growth factor homologous factors: Evolution, structure, and function

Goldfarb¹

2005

Cytokine & Growth Factor Reviews

185

170

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“…However, their roles and mechanisms of action are highly diverse. FGF11-FGF14 (iFGFs) function as intracellular proteins in an FGFR-independent manner (Wang et al, 2000;Goldfarb, 2005). In contrast, canonical FGFs function as extracellular proteins in an FGFR-dependent manner.…”

Section: Perspectivesmentioning

confidence: 99%

Functional evolutionary history of the mouse Fgf gene family

Itoh

Ornitz

2007

Developmental Dynamics

345

302

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Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene‐related peptide‐positive nociceptive neurons in the murine dorsal root ganglia

Hübert

Bourane

Ventéo

et al. 2008

J of Comparative Neurology

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Dorsal root ganglia (DRG) neurons exhibit a wide molecular heterogeneity in relation to the various sensory modalities (mechanoception, thermoception, nociception) that they subserve. Finding markers of subpopulations is an important step in understanding how these neurons convey specific information. We identified fibroblast growth factor homologous factor 1 (FHF1) in a search for markers of subpopulations of DRG neurons. FHFs constitute a family of four factors that share some structural properties with fibroblast growth factors (FGFs) but are functionally distinct. They are expressed in specific subsets of neurons and are involved in the modulation of sodium channel activity. The pattern of expression of FHF1 in the DRG was determined during development, in the adult and after axotomy. We show that in the adult, FHF1 is expressed in two populations, one composed of nociceptors and another in which no neurotrophic factor receptors were detected (panTrk-/c-Ret-). Interestingly, in the nociceptors, FHF1 expression was restricted to a subset of TrkA+/calcitonin gene-related peptide (CGRP)-positive neurons. Neurofilament 200 (NF-200) and peripherin labeling indicates that 70% of the FHF1-expressing neurons contribute to A-fibers and 30% to C-fibers. FHF1 interacts with the Na(v)1.9 sodium channel isoform, which is strongly expressed in cRet+/isolectin-B4 binding neurons, but we show that FHF1 is not expressed in the cRet+/IB4+ subclass and that it does not colocalize with Na(v)1.9. Our results argue strongly against the possibility that FHF1 has a modulatory effect on this channel in cRet+/IB4+ neurons, but FHF1 could play a role in a distinct subset of TrkA+/CGRP+ nociceptors.

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Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14

Cited by 85 publications

References 7 publications

Fibroblast growth factor homologous factors: Evolution, structure, and function

Fibroblast growth factor homologous factors: Evolution, structure, and function

Functional evolutionary history of the mouse Fgf gene family

Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene‐related peptide‐positive nociceptive neurons in the murine dorsal root ganglia

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