Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection
Cynthia C. Aguilar,
Anurag Kalia,
Morgan E. Brisse
et al.
Abstract:Lymph node (LN) germinal centers (GCs) are critical sites for B cell activation and differentiation. GCs develop after specialized CD169
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macrophages residing in LN sinuses filter antigens (Ags) from the lymph and relay these Ags into proximal B cell follicles. Many viruses, however, first reach LNs through the blood during viremia (virus in the blood), rather than through lymph drainage from infected tissue. How LNs capture viral Ag from the blood to allow GC development is not known.… Show more
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