Subcapsular Liver Tumors Treated with Percutaneous Radiofrequency Ablation: A Prospective Comparison with Nonsubcapsular Liver Tumors for Safety and Effectiveness

Sartori, Sergio; Tombesi, Paola; Macario, Francesca; Nielsen, Ingrid; Tassinari, Davide; Catellani, M.; Abbasciano, Vincenzo

doi:10.1148/radiol.2482071690

Cited by 67 publications

(40 citation statements)

References 37 publications

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“…A low mortality rate after RFA was reported, ranging from 0% to 2.9%. 5,7,20,21,23,27,34,35 The mortality rate related to surgical resection was 3.1%, which is comparable to other studies (0%-15%). [36][37][38][39] These results demonstrate that RFA combined with TACE is safe.…”

Section: Discussionsupporting

confidence: 83%

“…5,[20][21][22][23][24][25][26][27] Surprisingly, a histological study in patients who underwent liver transplantation after an RFA procedure revealed residual tumor tissue in 37% and 71% of patients with HCC 3 cm and HCC >3 cm, respectively. 28 The combination with TACE is expected to reduce such microscopic local tumor progression.…”

Section: Discussionmentioning

confidence: 99%

“…33 The major complication rate after RFA was 1.5%, which is comparable to the rates in other studies (1.9%-16%). 5,7,20,21,23,27,34,35 RFA-related death was observed in 1 (0.8%) patient. A low mortality rate after RFA was reported, ranging from 0% to 2.9%.…”

Section: Discussionmentioning

confidence: 99%

“…Livraghi et al 40 reported that RFA was not feasible in 6.0% of patients because of high-risk tumor location or poor detection on ultrasonography. Although new technologies, such as artificial pleural effusion or ascites, increase the number of patients eligible for RFA, 7,27,41 surgical resection should be chosen for the treatment of patients with high-risk tumor location.…”

Section: Discussionmentioning

confidence: 99%

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Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Kagawa

Koizumi

Kojima

et al. 2010

Cancer

104

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the Tokai RFA Study Group BACKGROUND: Radiofrequency ablation (RFA) is becoming a well-known local therapy for hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) is expected to enhance the effects of subsequent RFA by reducing arterial blood flow. However, the long-term efficacy of this combined therapy has not been elucidated. In this study, the survival rates of patients who received TACE combined with RFA (TACE þ RFA) were compared with those of patients treated surgically. METHODS: The study included consecutive patients who received TACE þ RFA or surgical resection as the initial curative treatment for HCC between 2000 and 2005 at Tokai University Hospital. Inclusion criteria were a single HCC 50 mm or up to 3 HCCs 30 mm, presence of cirrhosis classified as Child-Pugh class A, no vascular invasion, and no extrahepatic metastasis. RESULTS: Sixty-two patients (23 women, 39 men; aged 67.5 AE 8.4 years [mean AE standard deviation]) received TACE þ RFA, and 55 patients (15 women, 40 men; aged 66.1 AE 8.4 years) underwent surgical resection. Median follow-up periods were similar (50 months in the TACE þ RFA group vs 49 months in the resection group). The probabilities of overall survival at 1, 3, and 5 years in the TACE þ RFA group (100%, 94.8%, and 64.6%, respectively) were similar (P ¼ .788) to those in the resection group (92.5%, 82.7%, and 76.9%, respectively). Two major RFA-related complications were observed (1.5%). CONCLUSIONS: RFA combined with TACE is an efficient and safe treatment that provides overall survival rates similar to those achieved with surgical resection. Cancer 2010;116;3638-44.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Kagawa

Koizumi

Kojima

et al. 2010

Cancer

104

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“…Radiofrequency ablation (RFA) is an important and minimal-invasive treatment option for hepatic tumors and metastases [1][2][3][4][5][6][7]. It belongs to the energy-based ablation modalities and relies on proper needle electrode placement into the tumor via an open, laparoscopic or percutaneous approach.…”

Section: Introductionmentioning

confidence: 99%

Characterization of benign periablational enhancement following multipolar radiofrequency ablation using perfusion CT in an in-vivo porcine liver model

Vahldiek

Thieme

Gemeinhardt

et al. 2017

JCB

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Abstract. PURPOSE:Thermal ablation is an important interventional option in the management of liver tumors. Immediate postablational imaging regularly shows periablational enhancement. This peripheral hyperperfusion may induce heat-sink effects which could contribute to incomplete tumor ablation. To reduce the effect of hyperperfusion the feeding vessels source must be known. The aim of this study was to dynamically characterize the type of blood supply of the periablational enhancement zone immediately after hepatic radiofrequency ablation (RFA) using perfusion CT. METHODS:We used an in-vivo porcine liver model. Multipolar RFA was performed in healthy pig livers. Immediate postablational perfusion CT was acquired. The contrast enhancement over time of the peripheral ablation zone, the aorta and the portal vein were recorded. Time differences of the peak periablational enhancement to the peak arterial perfusion and to the peak portalvenous perfusion were calculated and analyzed. RESULTS: The perfusion peak of the periablational enhancement zone always occurred in mean 8.1 s after the arterial peak in the aorta and in mean 16.9 s before the peak in the portal vein. CONCLUSIONS: Benign periablational enhancement is a result of primary arterial and not portalvenous hyperperfusion. In order to reduce heat sink effects, peri-ablational arterial balloon occlusion or transarterial chemoembolization may be beneficial during RFA.

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Liver Neuroendocrine Metastases Laser Ablation

Sartori¹,

Vece²,

Tombesi³

et al. 2019

Image-Guided Laser Ablation

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Subcapsular Liver Tumors Treated with Percutaneous Radiofrequency Ablation: A Prospective Comparison with Nonsubcapsular Liver Tumors for Safety and Effectiveness

Abstract: The difference in major complication rate between the subcapsular and nonsubcapsular liver tumors was not significant. The safety of RF ablation of subcapsular tumors seems acceptable, and the effectiveness is comparable to that of RF ablation of nonsubcapsular tumors.

Cited by 67 publications

References 37 publications

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Characterization of benign periablational enhancement following multipolar radiofrequency ablation using perfusion CT in an in-vivo porcine liver model

Liver Neuroendocrine Metastases Laser Ablation

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