Subarachnoid Hemorrhage During Sexual Activity After Sildenafil Intake

Abstract

We report and describe an autopsy case of a man dead for rupture of cerebral artery aneurysm with subsequent subarachnoid hemorrhage after sexual intercourse. Toxicologic analysis demonstrated that he had consumed sildenafil (Viagra). Although subarachnoid hemorrhage has been reported to be associated with sexual intercourse, it is not among the known adverse effects of sildenafil. However, sildenafil has been found to interact with vascular physiology via multiple mechanisms and in most of the vascular districts of the human body. This case provides an example of a very rare association between this drug and a fatal pathologic event and deserves to be added to the existing clinical knowledge about sildenafil and the pathophysiology of the events involved. This knowledge may be helpful in orienting further investigation into the mechanisms of action of sildenafil and their clinical implications.

Subarachnoid haemorrhage following first use of Sildenafil

“…14 The last describes a 49-year-old man who was dead on arrival to hospital following a catastrophic SAH. 15 In addition to these, we identified five cases in the literature of intracerebral haemorrhage following the use of Sildenafil. [16][17][18][19][20]…”

Review of Severe Headache after Sexual Activity with a Case Presentation

“…Albano ve arkadaşları seksüel aktivite sonrası 78 yaşında erkek hastada intraserebral venöz hemoraji gelişen bir olgu bildirmişlerdir (9). De-Giorgio ve arkadaşları sildenafil kullanımı sonrasında serebral arter rüptürü sonrasında ölümle sonuçlanan SAK olgusu paylaşmışlardır (10). Bizim olgumuz literatürdeki olguların yaş ortalamasından daha küçük olmakla birlikte intrakraniyal anevrizmasının olması serebral perfüzyon basıncınındaki ani değişiklikleri kompanse edememiş ve anevrizmanın rüptürüne yol açmıştır.…”

Death Related to Aortic Coarctation in a Young Female During Sexual Intercourse

“…We described an autopsy case of a man dead because of rupture of a cerebral artery aneurysm with subsequent subarachnoid hemorrhage after sexual intercourse. Toxicological analysis demonstrated that he had consumed a drug (Sildenafil) prior to sexual activity (6). Like any form of physical exertion, sexual intercourse increases heart rate and blood pressure (7).…”