Subarachnoid hemorrhage and systemic lupus erythematosus

Matsubara, Akio; Suzuki, Tomohiko; Hashimoto, Masao; Nara, Hiroyuki; Yoshio, Taku; Masuyama, Jun-Ichi; Okazaki, H; Hirata, Daisuke; Kano, Shogo; Minota, Seiji

doi:10.1177/096120330000900708

Cited by 52 publications

(60 citation statements)

References 14 publications

(3 reference statements)

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“…22 Their association is mediated by vasculitis. A recent case-control study has reported that transfusion was associated with the development of systemic lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Fatal Subarachnoid Hemorrhage

Yamada

Iso²,

Wada³

et al. 2003

Stroke

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MD; for the JACC Study GroupBackground and Purpose-The present study aimed to identify risk factors for mortality due to subarachnoid hemorrhage (SAH) using a comprehensive questionnaire from the Japan Collaborative Cohort (JACC) Study, a Japan-wide population-based prospective study. Methods-A total of 109 293 individuals (45 551 men and 63 742 women, aged 40 to 79 years) free of stroke at entry participated in the JACC Study between 1988 and 1990. Participants were followed up annually until they died or moved away from the surveyed community, or until the end of 1999. A diagnosis of death from SAH was based on the International Classification of Diseases, 10th revision (ICD-10). The age-adjusted univariate and multivariate hazard ratios (HR) and 95% confidence intervals (CI) of various factors were calculated in sex-stratified and sex-specific analyses using the Cox proportional hazards regression model. Results-A total of 244 individuals (88 men and 156 women) died from SAH during the follow-up of 1 086 963 person-years. Our univariate analyses confirmed that preference for salty foods and history of blood transfusion, as well as hypertension, family history of stroke, cigarette smoking, heavy alcohol consumption, and low BMI, had statistically significant associations with mortality due to SAH. Multivariable analyses revealed that history of blood transfusion was an independent significant risk factor (HRϭ4.2 [95%CI, 2.1 to 8.5]) for men, while preference for salty foods or heavy drinking were not. Conclusions-History of blood transfusion was found to be an independent risk. The association between SAH and blood transfusion warranted further study.

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“…22 Their association is mediated by vasculitis. A recent case-control study has reported that transfusion was associated with the development of systemic lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Fatal Subarachnoid Hemorrhage

Yamada

Iso²,

Wada³

et al. 2003

Stroke

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“…Our hypothesis is in accordance with clinical experiences in which IA is often found in subjects with autoimmune diseases. 29,30 Further studies are needed to strengthen our hypothesis. In addition, the present results might pave the way for an investigation of a link between immunologic events and IA development.…”

Section: Inoue Et Al Tnfrsf13b and Intracranial Aneurysm 2007mentioning

confidence: 81%

Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm

et al. 2006

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Background-Our previous studies have shown a significant linkage of intracranial aneurysms (IAs) to chromosome 17. Methods and Results-Nine genes (TNFRSF13B, COPS3, RAI1, SREBF1, GRAP, MAPK7, MFAP4, and AKAP10) were selected from 108 genes that are located between D17S1857 and D17S1871 by excluding 99 genes that were pseudogenes, hypothetical genes, or well-characterized genes but not likely associated with IA. Direct sequencing of all coding and regulatory regions in 58 cases (29 pedigree probands and 29 unrelated nonpedigree cases) was performed. Deleterious changes were found only in TNFRSF13B, K154X, and c.585 to 586insA in exon4. The association of IA with TNFRSF13B was further studied in 304 unrelated cases and 332 control subjects. Rare nonsynonymous changes, a splicing acceptor site change and a frame shift, were found in unrelated cases (2.3%; 14 of 608) more frequently than in control subjects (0.8%; 5 of 664; Pϭ0.035). The association study using single-nucleotide polymorphisms in an unrelated case-control cohort revealed a protective haplotype (odds ratio 0.69, 95% confidence interval 0.52 to 0.92, Pϭ0.012) compared with the major haplotype after adjustment for covariates. Conclusions-We propose that TNFRSF13B is one of the susceptibility genes for IA.

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“…The incidence of subarachnoid hemorrhage (SAH) in SLE patients is low, 10) with frequency ranging from 0.93% to 3.9%. 2,12) Analysis of 57 Japanese patients with SAH associated with SLE found 38 patients had cerebral aneurysms. 17) Neurosurgical procedures, such as surgical clipping, were performed in 22 patients.…”

Section: Discussionmentioning

confidence: 99%

Successful Flow Reduction Treatment for a Middle Cerebral Artery Aneurysm in a Patient With Systemic Lupus Erythematosus

Takemoto

Abekura

Takahashi

et al. 2013

Neurol. Med. Chir.(Tokyo)

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A 37-year-old male with a 20-year history of systemic lupus erythematosus (SLE) was referred to our hospital for an unruptured right middle cerebral artery (MCA) aneurysm. Right cerebral angiography detected a saccular aneurysm (9.6 × 7.1 mm) arising from the bifurcation of the right MCA, and a dilatation of the inferior trunk M 2 in which three small branches were involved. The MCA aneurysm was treated with neck clipping. The aneurysmal dilatation of the inferior trunk M 2 was treated with proximal clipping, followed by double superficial temporal artery-MCA anastomosis. The patient was discharged from our hospital without complications. This is an extremely unusual case of surgical flow reduction treatment using bypass surgery for a complicated cerebral aneurysm in a patient with SLE.

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Subarachnoid hemorrhage and systemic lupus erythematosus

Cited by 52 publications

References 14 publications

Risk Factors for Fatal Subarachnoid Hemorrhage

Risk Factors for Fatal Subarachnoid Hemorrhage

Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm

Successful Flow Reduction Treatment for a Middle Cerebral Artery Aneurysm in a Patient With Systemic Lupus Erythematosus

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