Subarachnoid haemorrhage in the rat: effect on the development of cerebral vasospasm of lesions in the central serotoninergic and dopaminergic systems.

Abstract

SUMMARYIn the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is suggested that neither system plays a role in the development of spasm.

Organization of cholinergic, putative catecholaminergic and serotonergic nuclei in the diencephalon, mibrain and pons of sub-adult male giraffes

“…Svendgaard et al, 1986) in the laboratory rat. Noradrenaline released in the NTS has a hypotensive or hypertensive function dependent upon the main adrenergic receptor subtype activated with the alpha2 adrenergic receptors producing vasodepressor responses (Bolme et al, 1973;Yang et al, 1994;Kobilansky et al, 1988).…”