Subarachnoid haemorrhage as the first clinical manifestation of Churg-Strauss syndrome

Sheerin, Una‐Marie; Barreto, J.; Brown, Martin M.; Brew, Stefan; Losseff, Nicholas

doi:10.1007/s00415-008-0765-2

Cited by 17 publications

(7 citation statements)

References 7 publications

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“…In these cases, cerebral ischemic infarction (~80%) and diffuse encephalopathy (~10%) have been by far the findings most frequently reported. Published data on EGPA with CNS hemorrhage are limited to anecdotal case reports [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]21,22,23,24,25,26 . We described a case of EGPA presenting with intracerebral hemorrhage (ICH) and did a comprehensive review of the literature.…”

Section: Demographic and Clinical Characteristics Associated With Cenmentioning

confidence: 99%

Demographic and Clinical Characteristics Associated with Central Nervous System Hemorrhage in Patients with Eosinophilic Granulomatosis with Polyangiitis: A Case Report and Review of the Literature

2017

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Section: Demographic and Clinical Characteristics Associated With Cenmentioning

confidence: 99%

Demographic and Clinical Characteristics Associated with Central Nervous System Hemorrhage in Patients with Eosinophilic Granulomatosis with Polyangiitis: A Case Report and Review of the Literature

2017

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“…3 ). Additional less commonly reported CNS events include intracerebral haemorrhage [78, 79] and pachymeningitis [80, 81]. …”

Section: Systemic Vasculitides Involving the Cnsmentioning

confidence: 99%

Central Nervous System Vasculitis: Still More Questions than Answers

Alba¹,

Espígol‐Frigolé²,

Prieto-González³

et al. 2011

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The central nervous system (CNS) may be involved by a variety of inflammatory diseases of blood vessels. These include primary angiitis of the central nervous system (PACNS), a rare disorder specifically targeting the CNS vasculature, and the systemic vasculitides which may affect the CNS among other organs and systems. Both situations are severe and convey a guarded prognosis. PACNS usually presents with headache and cognitive impairment. Focal symptoms are infrequent at disease onset but are common in more advanced stages. The diagnosis of PACNS is difficult because, although magnetic resonance imaging is almost invariably abnormal, findings are non specific. Angiography has limited sensitivity and specificity. Brain and leptomeningeal biopsy may provide a definitive diagnosis when disclosing blood vessel inflammation and are also useful to exclude other conditions presenting with similar findings. However, since lesions are segmental, a normal biopsy does not completely exclude PACNS. Secondary CNS involvement by systemic vasculitis occurs in less than one fifth of patients but may be devastating. A prompt recognition and aggressive treatment is crucial to avoid permanent damage and dysfunction. Glucocorticoids and cyclophosphamide are recommended for patients with PACNS and for patients with secondary CNS involvement by small-medium-sized systemic vasculitis. CNS involvement in large-vessel vasculitis is usually managed with high-dose glucocorticoids (giant-cell arteritis) or glucocorticoids and immunosuppressive agents (Takayasu’s disease). However, in large vessel vasculitis, where CNS symptoms are usually due to involvement of extracranial arteries (Takayasu’s disease) or proximal portions of intracranial arteries (giant-cell arteritis), revascularization procedures may also have an important role.

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“…1)2)5)8)10-13)15)18)19) SAH has been documented in a few patients in CSS 1)18)19). It is believed that neutrophils may cause damage to normal tissue, which can result in development of vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Subarachnoid and Intracerebral Hemorrhage in Patients with Churg-Strauss Syndrome: Two Case Reports

Park

Kang

et al. 2012

J Cerebrovasc Endovasc Neurosurg

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Churg-Strauss syndrome (CSS) is a systemic necrotizing vasculitis of the small and medium vessels, associated with extravascular eosinophilic granulomas, peripheral eosinophilia, and asthma. The exact etiology of CSS is unknown. This syndrome commonly affects the lungs, peripheral nerves, skin, heart, and gastrointestinal tract, but rarely the central nervous system. Subarachnoid and intracerebral hemorrhage in CSS patients is extremely rare; however, clinicians should consider that CSS may be a cause of intracranial hemorrhage and its high rate of mortality and morbidity. The authors report on two cases of subarachnoid and intracerebral hemorrhage with CSS and discuss a brief review of CSS.

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Subarachnoid haemorrhage as the first clinical manifestation of Churg-Strauss syndrome

Cited by 17 publications

References 7 publications

Demographic and Clinical Characteristics Associated with Central Nervous System Hemorrhage in Patients with Eosinophilic Granulomatosis with Polyangiitis: A Case Report and Review of the Literature

Demographic and Clinical Characteristics Associated with Central Nervous System Hemorrhage in Patients with Eosinophilic Granulomatosis with Polyangiitis: A Case Report and Review of the Literature

Central Nervous System Vasculitis: Still More Questions than Answers

Subarachnoid and Intracerebral Hemorrhage in Patients with Churg-Strauss Syndrome: Two Case Reports

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