2020
DOI: 10.1016/j.cub.2020.07.008
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Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia

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Cited by 43 publications
(49 citation statements)
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References 81 publications
(125 reference statements)
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“…A small metal baseplate is glued around the lens, and the headmounted miniscope is magnetically attached to the baseplate. As established in our published studies (Grieco et al, 2021;Grieco et al, 2020;Sun et al, 2019;Wong et al, 2021), GRIN lens implants and the stability of the miniscope attachment permit longitudinal dynamic imaging results to be aligned across sessions and multiple days due to stable registration. Hundreds of neurons can be captured simultaneously in a 700 μm x 450 μm field of view, with a resolution of ~0.9 μm per pixel (Fig.…”
Section: Miniscope Imaging Of Neural Population Activities In 3xtg-ad Hippocampal Ca1mentioning
confidence: 86%
“…A small metal baseplate is glued around the lens, and the headmounted miniscope is magnetically attached to the baseplate. As established in our published studies (Grieco et al, 2021;Grieco et al, 2020;Sun et al, 2019;Wong et al, 2021), GRIN lens implants and the stability of the miniscope attachment permit longitudinal dynamic imaging results to be aligned across sessions and multiple days due to stable registration. Hundreds of neurons can be captured simultaneously in a 700 μm x 450 μm field of view, with a resolution of ~0.9 μm per pixel (Fig.…”
Section: Miniscope Imaging Of Neural Population Activities In 3xtg-ad Hippocampal Ca1mentioning
confidence: 86%
“…By contrast, the excitability of FS-GABAergic interneuron was not reduced in ctoNrg1 mice where Nrg1 was overexpressed in excitatory pyramidal neurons 26 . Recent studies indicated that NRG1 was highly expressed in PV-positive GABAergic interneurons and was important for the plasticity of the visual cortex 56,57 . Together, these results demonstrated the function of NRG1 in GABAergic interneurons.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the highly-selective NMDA receptor antagonist MK-801, a ligand with similar mechanisms to ketamine, has been found to increase gamma in the cortex by targeting pyramidal neurons and PV-interneurons (Hudson et al, 2020). Ketamine's therapeutic effects also extend to alleviating amblyopia via inhibitory cortical PV-neurons (Grieco et al, 2020). Prior work has shown that the long-term anti-dyskinetic effect of ketamine correlates with changes in dendritic spine density, specifically a reduction of multi-synaptic mushroom spines, in the striatum, yet changes in dendritic spines in the M1 had not been investigated in that study.…”
Section: Ketamine Exposure Is Associated With a Days-long Increase Inmentioning
confidence: 99%