Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1

Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway

“…Previous studies reported that ERK activation may contribute to initiate p53/p21-dependent mechanisms, which promotes apoptotic cell death Liu et al (2011)). Consistently, our results indicated that administration of Scutellaria baicalensis extract significantly promoted phosphorylation of ERK1/2 within 3 h, implying that Scutellaria baicalensis-induced ERK activation contributes to p53 activation, which subsequently promotes apoptosis of HSC-T6 cells.…”

Study on Cinnamomum Oils: Compositional Pattern of Seven Species Grown in Vietnam

“…The genus contains over 300 species, distributed in tropical and subtropical regions of North America, Central America, South America, Asia, Oceania and Australasia. The genus is a source of various biologically active compounds 3,4 .…”

Tenuifolide B from Cinnamomum tenuifolium Stem Selectively Inhibits Proliferation of Oral Cancer Cells via Apoptosis, ROS Generation, Mitochondrial Depolarization, and DNA Damage

“…For example, the cytotoxicity (IC 50 ) is known for several Cinnamomum plants. Cinnamaldehyde from C. zeylanicum and C. cassia barks is effective against colon cancer (HT29) = 19.7 μM at 72 h [12], (3 R ,9 S )-megastigman-5-ene-3,9-diol 3- O -β- d -glucopyranoside from C. wilsonii leaves against colon cancer SW-480 cells = 12 μM at 48 h [13], isoobtusilactone A from C. kotoense leaves against human hepatoma Hep G2 cells = 37.5 μM at 18 h [15], cinnakotolactone from C. kotoense leaves against human colorectal cancer HT29 and breast MCF-7 cells = 25.8 and 24.4 μM at 72 h [17], subamone from C. subavenium leaves against prostate cancer LNCaP cells = 7.01 μM at 24 h [18], subamolide B from C. subavenium stems against melanoma A375 cells = 17.59 μΜ at 48 h [19], and subamolide A from C. subavenium stems against human prostate cancer PC3 cells = 10.1 μM at 72 h [20]. It has to be noted that some of the IC 50 values were determined after 72 h of treatment.…”

“…Many bioactive extracts and isolated compounds have been extracted from the bark of Cinnamomum of the Formosan Lauraceous family ( C. zeylanicum and C. cassia ) [12], leaves ( C. wilsonii [13], C. kotoense [14,15,16,17], C. subavenium [18]), stems ( C. subavenium [19,20]), and heartwood and roots ( C. osmophloeum [21]). These findings indicate the antiproliferative effect of Cinnamomum plants for several types of cancer, such as that of the colon [12,13,17], lung [14,16], liver [15,21], breast [17], prostate [18,20], melanoma [19], and bladder [20]. However, the selective killing effect of Cinnamomum plants on oral cancer cells remains undetermined.…”