Subakute Chloroquin-Überdosierung

Abstract

Owing to a misunderstanding a 26-year-old man took for malaria prevention 2 tablets (1.0 g) chloroquine daily instead of the recommended dose of two tablets weekly. After 2 weeks he developed vertigo, generalized weakness and, after sun-bathing, severe bullous light reaction. After 4 weeks generalized hair depigmentation occurred. Two weeks later abnormal accommodation and double vision set in so that he lost distant and near vision. All these signs disappeared after the drug was discontinued (vertigo, weakness and abnormal accommodation within 2 weeks; hair regrew in normal colour after 8 weeks). This case shows the whole spectrum of subacute chloroquine overdosage.

Chloroquine –Induced Hair Depigmentation

“…5 Besides generalised hair depigmentation, other symptoms have also been observed, such as vertigo, generalised weakness, severe bullous light reaction and double vision, which disappeared after discontinuation of the treatment. 7 In spite of being an 11-year-old child with an even higher dosage and prolonged exposure, our patient did not experience any of these symptoms. Acute overdose is potentially lethal, causing hypokalemia, prolonged QTc interval, seizures, central nervous system depression and cardiac arrest, which were not observed on the present case either.…”

Thrombocytopenia Secondary to Hydroxychloroquine Intake Mimicking Dengue Infection: A Case Report

“…Common side effects of hydroxychloroquine encompass anorexia, diarrhea, and nausea. Other manifestations include exanthema, hyperpigmentation, photodynamic reaction, retinopathy and rarely psychosis and auditory impairment [1]. Here, we describe the case of a 63-year-old female who presented to the emergency department with an eight-day history of fever, body aches, and bilateral leg pain.…”