Subacute toxicity assessment of biobased ionic liquids in rats

Hijo, Ariel A.C. Toledo; Barros, Helena Dias de Freitas Queiroz; Máximo, Guilherme J.; Cazarin, Cínthia Baú Betim; Costa, Larissa Bastos Eloy da; Pereira, Jorge Fernando Brandão; Maróstica, Mário Roberto; Meirelles, Antônio José de Almeida

doi:10.1016/j.foodres.2020.109125

Cited by 15 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ILs with fatty acid anions (bis(2-hydroxyethyl)ammonium caprate ((HOC 2 ) 2 NH 2 Capr) and bis(2-hydroxyethyl)ammonium oleate ((HOC 2 ) 2 NH 2 Ole)) caused no significant signs of subacute toxicity in rats after 30 days of exposure at doses up to 3.2% w IL /w oil , according to lipid peroxidation in the liver, kidney, and plasma. An IL dose-dependent increase in the levels of triglycerides was detected in the plasma, possibly due to IL-related facilitation of the digestion of lipid compounds present in the diet …”

Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 97%

“…An IL dose-dependent increase in the levels of triglycerides was detected in the plasma, possibly due to IL-related facilitation of the digestion of lipid compounds present in the diet. 426 Several common ILs were tested for their skin sensitization potential in mice. C 2 MIm Cl induced no skin sensitization or irritation at the concentrations tested (6.25−50%).…”

Section: Mammalsmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

View full text Add to dashboard Cite

The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

show abstract

Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 97%

Section: Mammalsmentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

View full text Add to dashboard Cite

show abstract

“…[13][14][15][16] A large number of task-specific ILs have been created from various combinations of environmentally friendly and low-cost bio-based ions, which has attracted researchers' attention. 16,17 Biobased ILs, derived from renewable and non-toxic biosources such as amino acids 18 from proteins, sugar 19 from cellulose and fatty acids 20 from vegetables, offer promising solutions for addressing issues such as water pollution, oil depletion and medical applications. 12,19,21 Long-chain fatty acid ionic liquids (LCFA-ILs) are a particular class of bio-based ILs obtained from algae-derived oils or vegetables.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Properties of Fatty Acid-based Ionic Liquids: Advancement in AMOEBA Force Field

Heidari,

Torabifard

2024

Preprint

View full text Add to dashboard Cite

Developing the multipolar-polarizable AMOEBA force field for large molecules presents its own set of complexities. However, by segmenting the molecules into smaller fragments and ensuring that each fragment is transferable to other systems, the process of parameterizing large molecules such as fatty acids can be simplified without compromising accuracy. In this study, we present a fragment- based AMOEBA FF development for long-chain fatty acid ionic liquids (LCFA-ILs). AMOEBA enables us to incorporate polarization to measurably enhance the precision in modeling these large highly charged systems. This is of significant importance since the computational investigation of ILs needs accurate modeling. Additionally, to leverage the tunability of ILs, it is essential to test numerous anion and cation combinations to identify the most suitable formulation for each application. However, conducting such experiments can be resource-intensive and time-consuming, but accurate molecular modeling can expedite the exploration process. Here, the newly developed parameters were evaluated by comparing the decomposed intermolecular interaction energies for ion pairs with energies determined by quantum mechanics calculations as a reference. By employing this FF in molecular dynamics simulations, we predicted bulk and structural properties including density, enthalpy of vaporization, diffusion coefficient, and radial distribution function of diverse LCFA-ILs. Notably, the good agreement between the experimental data and those calculated using our parameters validates the accuracy of our methodology. Therefore, this new procedure provides an accurate approach to parameterizing large systems, paving the way for studying more complicated systems such as lipids, polymers, micelles and membrane proteins.

show abstract

“…This might be more relevant, considering that the food industry has a crucial role to combat the COVID-19 pandemic offering healthier foods and food supplements containing essential nutrients, such as omega fatty acids (FAs) and choline (Ch) 3,4 , which are required to reach a well nutritional balance necessary to improve the immune system. Ionic liquids (ILs), defined as salts that melt below 100 °C, are versatile compounds with potential use in food industry [5][6][7][8][9] . Few examples of traditional ILs, such as imidazolium-based, have been used in emulsion encapsulation as core material and as disperse or continuous phases 10 , and they may not be recommended for direct food applications 6 .…”

mentioning

confidence: 99%

“…Ionic liquids (ILs), dened as salts that melt below 100 °C, are versatile compounds with potential use in the food industry. [5][6][7][8][9] Few examples of traditional ILs, such as imidazolium-based, have been used in emulsion encapsulation as the core material and as disperse or continuous phases, 10 and they may not be recommended for direct food applications. 6 In the fragrance eld, ILs have been employed by Procter and Gamble (P&G), 11 while FA-based ILs have been used in mixtures with EOs comprising a non-emulsion system to improve the storage and release of fragrance components.…”

mentioning

confidence: 99%

Novel naturally derived encapsulation agents in the ionic liquid form for sustainable emulsion-based products

Hijo¹,

Silva²,

Meirelles³

et al. 2023

Sustainable Food Technol.

View full text Add to dashboard Cite

show abstract

Subacute toxicity assessment of biobased ionic liquids in rats

Cited by 15 publications

References 36 publications

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Investigating the Properties of Fatty Acid-based Ionic Liquids: Advancement in AMOEBA Force Field

Novel naturally derived encapsulation agents in the ionic liquid form for sustainable emulsion-based products

Contact Info

Product

Resources

About