Subacute thyroiditis might be a complication triggered by SARS-CoV-2

Ruano, R. Molina; Zorzano-Martínez, Marta; Campos, Aline Alves Scarpellini; Rius, Ferrán; Hernández, Marta

doi:10.1016/j.endinu.2020.09.002

Cited by 16 publications

(19 citation statements)

References 6 publications

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“… Spain F 28 No 14 Fever, anterior neck pain, palpitations, severe asthenia TSH <0.001 mU/L FT4 67.5 pmol/L (nv 7–16) TgAb, TPOAb and TRA undetectable Elevated ESR and CRP TS: absent 99mTc-perthecnetate uptake Pain-killers (aspirin) and betablockers (propanolol 40 mg every 6 h). Thyroid functional tests and inflammatory indexes normalized within two weeks [ 53 ] Brancatella A et al . Italy [ 54 ] Patient 1 F 38 No 16 Anterior neck pain, fever asthenia, anorexia, palpitations, atrial fibrillation TSH 0.1 mIU/mL (n.v.…”

Section: Destructive Thyrotoxicosis In Covid-19 Patientsmentioning

confidence: 99%

“…Also, concurrent interfering factors, like drugs or iodine-containing contrast agents, should be taken into account in this setting of patients ( Table 2 ) [ 61 ]. As concerns imaging studies, when allowed to perform them in isolated patients, thyroid ultrasonography often demonstrated a heterogeneous hypoechoic, non-vascularized gland, while scintigraphy revealed a reduced or near-absent uptake, representing the diagnostic hallmark of SAT [ 31 , 44 , 46 , 48 , 53 , 59 , 61 ]. While some patients were followed up without any specific treatment or received only symptomatic treatment with beta-blockers, an anti-inflammatory therapy with corticosteroids or non-steroidal drugs (NSAID) was prescribed in those who experienced a severe discomfort and have developed SAT after the resolution of COVID-19 symptoms (or were asymptomatic for COVID-19).…”

Section: Destructive Thyrotoxicosis In Covid-19 Patientsmentioning

confidence: 99%

See 1 more Smart Citation

SARS-COV-2-related immune-inflammatory thyroid disorders: facts and perspectives

Ruggeri

Campennì

Deandreis

et al. 2021

Expert Review of Clinical Immunology

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Introduction : During the COVID-19 pandemic thyroid gland alteration/dysfunction has been emerged as a possible endocrine complication. The present review is focused on inflammatory and autoimmune thyroid complications triggered by SARS-CoV-2 infection by searching through databases like MEDLINE and Scopus up to April 2021. Areas covered : Beside the occurrence of ‘non-thyroidal illness’ in severe clinical conditions, alterations of thyroid function and structure may occur during COVID-19 as a consequence of either direct or indirect effects of SARS-CoV-2 infection on the gland. On the one hand, SARS-CoV-2 uses ACE2 as a receptor to infect the host cells and ACE2 is highly expressed by follicular thyroid cells. On the other hand, COVID-19 is associated with a systemic inflammatory and immune response, involving Th1/Th17/Th2 lymphocytes and proinflammatory cytokines, which resembles the immune activation that occurs in immune-mediated thyroid diseases. COVID-19-related thyroid disorders include destructive thyroiditis and onset or relapse of autoimmune thyroid disorders, leading to a broad spectrum of thyroid dysfunction ranging from thyrotoxicosis to hypothyroidism, that may worsen COVID-19 clinical course and affect prognosis. Expert opinion : Physicians should be aware of the possible occurrence of thyroid dysfunction during and after SARS-CoV-2 infection. Further longitudinal studies are warranted to evaluate potential long-term sequelae.

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Section: Destructive Thyrotoxicosis In Covid-19 Patientsmentioning

confidence: 99%

Section: Destructive Thyrotoxicosis In Covid-19 Patientsmentioning

confidence: 99%

SARS-COV-2-related immune-inflammatory thyroid disorders: facts and perspectives

Ruggeri

Campennì

Deandreis

et al. 2021

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…Subacute or de Quervain's thyroiditis is a granulomatous thyroiditis, usually during or after a viral episode in genetically predisposed patients (HLA-Bw35, HLA-B67, HLA-Drw8) [14]. Since the initial observation of subacute thyroiditis in a Covid-19 patient [15], at the present time 22 patients have been reported in the literature either as a clinical case report [15][16][17][18][19][20][21][22][23][24][25][26] or in small series of patients [27,28] (Table 1).…”

Section: Subacute or De Quervain's Thyroiditismentioning

confidence: 99%

Thyroiditis and SARS-CoV-2 pandemic: a review

Caron

2021

Endocrine

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The world is dealing with the Covid-19 pandemic due to the coronavirus SARS-CoV-2. Amongst the extra-pulmonary manifestations presented by Covid-19 patients, thyroiditis form part of the spectrum of visceral involvement linked to SARS-CoV-2. In this review, we will describe the various documented clinical forms of thyroiditis (inflammatory thyroiditis, subacute or de Quervain's thyroiditis, chronic lymphocytic thyroiditis or Hashimoto's disease, painless (silent) postpartum thyroiditis) to facilitate their diagnosis in more or less symptomatic Covid-19 patients and to provide guidance for patient treatment.

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“…В литературе детально описаны 15 клинических случаев подострого тиреоидита у пациентов, перенесших SARS-CoV-2, заболеваемость была в 4 раза выше среди женщин, медиана возраста составила 37,5 (29; 46) года [13][14][15][16][17][18][19][20][21][22][23][24]. Коронавирусная инфекция у больных подтверждалась положительным результатом ПЦР мазка из ротоглотки, чаще всего отмечалось легкое течение SARS-CoV-2, время от постановки диагноза COVID-19 до появления симптомов подострого тиреоидита варьировало от 5 до 49 дней, в трех случаях тиреоидит диаг ностировался одномоментно с SARS-CoV-2 при госпитализации по поводу коронавирусной инфекции.…”

Section: Endocrinologyunclassified

Thyroid Disorders and COVID-19

Petunina¹,

Taravi²,

Surkova³

et al. 2021

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Objective of the Review: To present the available information on the SARS-CoV-2 impact on thyroid gland (TG), impact from a thyroid pathology over COVID-19 morbidity and course, and management of patients with various thyroid pathologies and the novel coronavirus infection. Key Points. SARS-CoV-2 virus demonstrates exponential spread all over the globe and has caused a global pandemic of COVID-19 infection. Currently, the mechanism of non-pulmonary complications of SARS-CoV-2 and endocrine involvement is yet not clear. The impact from SARS-CoV-2 on TG can be a result of direct invasion of target cells by the virus or activation of immunise and inflammatory response.Changes in the pituitary-hypothalamic thyroid system can be caused by developing euthyroid pathology syndrome, glucocorticosteroid therapy, destructive thyroiditis. Manifestation of autoimmune thyroid disorders associated with COVID-19 cannot be ruled out. Conclusion. Currently there is no information on direct thyroid invasion by SARS-CoV-2; however the available results from trials and clinical observations demonstrate possible impact from coronavirus infections, in particular from SARS-CoV and SARS-CoV-2, on the pituitaryhypothalamic-thyroid system with development of various pathologies or a number of changes in thyroid hormone levels. Taking into account possible associations between thyroid dysfunction and prolonged hospitalisation, risk of deaths in hospital, and the association between thyrotoxicosis and atrial fibrillation and hypercoagulation, it is advisable to screen patients with severe COVID-19. Keywords: SARS-CoV-2, COVID-19, thyroid gland, nonsuppurative granulematous thyroiditis.

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Subacute thyroiditis might be a complication triggered by SARS-CoV-2

Cited by 16 publications

References 6 publications

SARS-COV-2-related immune-inflammatory thyroid disorders: facts and perspectives

SARS-COV-2-related immune-inflammatory thyroid disorders: facts and perspectives

Thyroiditis and SARS-CoV-2 pandemic: a review

Thyroid Disorders and COVID-19

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