Subacute Sclerosing Panencephalitis: Preceding Intellectual Deterioration and Deviant Measles Serology

Pettay, O; Donner, M.; Halonen, H; Palosuo, Timo; Salmi, A.

doi:10.1093/infdis/124.5.439

Cited by 28 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MIATERIALS AND METHODS Matched serum and CSF samples from eight cases of SSPE, plus a single serum sample from one more case of SSPE, three of which belonged to a group of patients described in a recent report (17), and from 15 well established cases of MS from the study population described in detail by Panelius (15) were examined. Twelve of the MS patients were chosen randomly and the remaining three patients (V. M., E. N., and J.…”

mentioning

confidence: 99%

Identification of Different Measles Virus-Specific Antibodies in the Serum and Cerebrospinal Fluid from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

1972

View full text Add to dashboard Cite

Matched serum and cerebrospinal fluid (CSF) samples from eight cases of subacute sclerosing panencephalitis (SSPE) and 15 cases of multiple sclerosis (MS) were characterized in neutralization, hemolysis-inhibition (HLI), hemagglutination-inhibition (HI) with Tween 80-ether-treated antigen, complement-fixation (CF), and immunodiffusion tests. CF tests were carried out with crude virus material, purified nucleocapsids, and small particle hemagglutinin as antigens. A certain diversity in the relative content of antibodies against different virus products in various sera was found. There was a high degree of correlation between titers of neutralizing and HLI antibodies, but a less strict correlation between titers of HLI and HI antibodies. Serum samples from two cases of MS and one case of SSPE contained high titers of HLI and neutralizing antibodies in the presence of only low titers of HI antibodies demonstrable with Tween 80-ether-treated antigen. The major fraction of antibodies detected in CF and immunodiffusion tests reacted with nucleocapsids. There was a tendency of nucleocapsid CF antibody titers, as compared to neutralization and HLI antibody titers, to be higher in samples from patients with SSPE than from cases of MS. No significant differences were found between antibody titers recorded in neutralization, HLI, and HI tests carried out with two different measles virus strains, Edmonston and a strain (LEC) derived from a case of SSPE. Comparison of antibodies against measles virus products and, as a reference, against a group-specific vertex capsomer antigen of adenovirus in matched serum and CSF samples revealed a production of measles virus-specific antibodies within the central nervous system of all cases of SSPE and 8 out of 15 cases of MS.

show abstract

mentioning

confidence: 99%

Identification of Different Measles Virus-Specific Antibodies in the Serum and Cerebrospinal Fluid from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

1972

View full text Add to dashboard Cite

show abstract

“…The antibody titres were not as high as those recorded in most patients with subacute sclerosing panencephalitis * * *, (Adams and Imagawa, 1962;Legg, 1967;Panelius et al, 1971;Pettay et al, 1971;Sever et al, 1971;Donner et al, 1972;McAlpine et al, 1972;Cendrowski et al, 1973;Panelius et al, el infiltratzon 1973).…”

Section: Resultsmentioning

confidence: 84%

Atypical demyelinating disease

Adams

Brown

Cremer

et al. 1974

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

“…If RF synthesis occurs in response to IgG in the form of antigen:antibody complexes, as has been suggested [Wager, 1976;Johnson and Faulk, 19761, these results are to be expected. A high MV IgG antibody response is found in serum throughout all stages of SSPE [Connolly et al, 1967;Pettay et al, 1971;Salmi et al, 19721 and periodic synthesis of MV antigens in the periphery during both acute and chronic stages of SSPE could lead to periodic formation of the immune complexes needed to trigger R F synthesis. The finding that RF levels are not greatly elevated in serum specimens from SSPE patients (Fig.…”

Section: Discussionmentioning

confidence: 99%

Synthesis of measles virus‐specific IgM antibodies and IgM‐class rheumatoid factor in relation to clinical onset of subacute sclerosing panencephalitis

Ziola

Halonen

Enders³

1986

Journal of Medical Virology

View full text Add to dashboard Cite

Thirty-seven serum and 37 cerebrospinal fluid (CSF) specimens from 27 patients with subacute sclerosing panencephalitis (SSPE) were tested for measles virus (MV) IgM antibodies and IgM-class rheumatoid factor (RF) to determine if a temporal relationship exists between SSPE onset and these immunoglobulins. Sensitive solid-phase radioimmunoassays were used for immunoglobulin detection. Five of six MV IgM-positive CSF, both MV IgM-positive sera and six out of eight sera with elevated RF levels were collected within 1 yr of SSPE onset. Also collected during this time were six other sera having high binding in the MV IgM assay, which was not due to MV-specific IgM antibodies. Two of these sera had as high or higher binding of IgM to a Vero cell control antigen, suggesting involvement of an IgM-class autoantibody. The other four sera had false-positive MV IgM assay results due to RF interference. RF interference was dependent on both the titer and avidity of the MV IgG antibodies involved. Three conclusions can be drawn from these results. First, MV IgM antibodies and elevated RF levels are not markers for acute SSPE, despite the tendency for their synthesis at this stage of the disease. Second, immunoassay analysis of viral IgM antibodies must employ an appropriate control antigen to account for background IgM binding. Finally, even if RF levels are normal or near normal, a false-positive IgM immunoassay result can still occur if antigen-specific IgG antibodies in the same sample have the right combination of titer and avidity.

show abstract

Subacute Sclerosing Panencephalitis: Preceding Intellectual Deterioration and Deviant Measles Serology

Cited by 28 publications

References 17 publications

Identification of Different Measles Virus-Specific Antibodies in the Serum and Cerebrospinal Fluid from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

Identification of Different Measles Virus-Specific Antibodies in the Serum and Cerebrospinal Fluid from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

Atypical demyelinating disease

Synthesis of measles virus‐specific IgM antibodies and IgM‐class rheumatoid factor in relation to clinical onset of subacute sclerosing panencephalitis

Contact Info

Product

Resources

About