Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the “Enhanced OECD Test Guideline no. 407”

Miyata, Katsumi; Shiraishi, Keiji; Houshuyama, Satsuki; Imatanaka, Nobuya; Umano, Takaaki; Minobe, Yasushi; Yamasaki, Kanji

doi:10.1007/s00204-005-0030-8

Cited by 31 publications

(16 citation statements)

References 18 publications

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“…DEHA (1,000 and 2,000 mg/kg/day), a phthalate alternative, increased atresia in preantral and antral follicles (Miyata et al 2006; Wato et al 2009). ATBC (5 and 10 mg/kg/day), a phthalate alternative, decreased the numbers of primordial, primary, and secondary follicles, but did not alter the numbers of corpora lutea or atretic follicles in mouse ovaries (Rasmussen et al 2016).…”

Section: Plasticizer Alternativesmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

257

150

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Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence. This review summarizes the effects of a variety of synthetic endocrine disrupting chemicals during adult life. The chemicals covered in this review are pesticides (organochlorines, organophosphates, carbamates, pyrethroids, and triazines), heavy metals (arsenic, lead, and mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate and bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, and parabens. This review focuses on the hypothalamus, pituitary, ovary, and uterus because together they regulate normal female fertility and the onset of reproductive senescence. The literature shows that several endocrine disrupting chemicals have endocrine disrupting abilities in females during adult life, causing fertility abnormalities in both humans and animals.

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Section: Plasticizer Alternativesmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

257

150

View full text Add to dashboard Cite

show abstract

“…It has been reported that repeated dosing of peroxisome proliferators including DEHA induced hypertrophic changes of the liver and kidney, which was characterized by increases in the number of peroxisomes (Holden et al, 1999). Eosinophilic change of proximal tubule was observed in previous repeated dose toxicity studies of DEHA (Miyata et al, 2006) and DEHP (David et al -ered attributable to the PPAR activation.…”

Section: Sp106mentioning

confidence: 95%

“…DEHA is widely used as a plasticizer in extensive array products, and has been reported that disturbance of the estrous cycle and increased ovarian follicle atresia were observed in the 1,000 mg/kg group (Miyata et al, 2006). DEHA was orally administered to Crl:CD(SD) female rats at the doses of 0, 200, 1,000 and 2,000 mg/kg for 2 weeks Day 7 of gestation 21 ± 3 22 ± 2 22 ± 3 24 ± 3* Mean estrous cycle length (day) 4.6 ± 1.7 4.2 ± 0.3 4.8 ± 0.5* 5.4 ± 1.1** No.…”

Section: Sp106mentioning

confidence: 99%

“…All groups consisted of 10 animals each. The doses were selected on the basis of previous report (Miyata et al, 2006). In the previous report, DEHA was orally administered to Crj:CD(SD) female rats at the doses of 0, 40, 200 and 1,000 mg/kg for 28 days from 8 weeks of age, and disturbance of the estrous cycle and increased ovarian follicle atresia were detected in the 1,000 mg/kg group.…”

Section: Female Fertility Studymentioning

confidence: 99%

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Collaborative work on evaluation of ovarian toxicity 9) Effects of 2- or 4-week repeated dose studies and fertility study of di(2-ethylhexyl)adipate (DEHA) in female rats

Wato

Asahiyama²,

Suzuki

et al. 2009

J. Toxicol. Sci.

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“…There are no adequate performed studies, which allow a precise determination of a NOAEL for DEHA from subchronic or chronic studies. A recent study based on the draft protocol for the "Enhanced OECD Test guideline no 407" using oral administration of 0, 40, 200, and 1000 mg/day for 28 days showed a reduction in relative kidney weights at 200 and 1000 mg/kg/day (Miyata et al 2006).…”

Section: Toxicitymentioning

confidence: 99%

Plasticizer concentration in cord blood cryopreserved with DMSO

Yamaguchi

Takanashi

Ito

et al. 2013

Bone Marrow Transplant

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The Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) has evaluated the exposure to DEHP for the general population and patients during medical procedures. In many cases the exposure is significant and exceeds the toxic doses observed in animal studies. There is limited evidence indicating a relation between DEHP exposures and certain effects in humans. However, it is recognised that especially the potentially high exposure during medical treatments raise a concern, even in the absence of clinical or epidemiological evidence, for harmful effects in humans. For certain uses of DEHP alternative plasticizers for PVC are available. The Committee got access to toxicity data for eight possible alternative plasticizers and compared their toxicity with that of DEHP. In respect to reproductive toxicity in animal studies DEHP induces more severe effects compared with some of the alternatives. A risk assessment of these available alternative plasticizers could not be performed due to a lack of exposure data from medical devices. Each alternative to DEHP, however, must also be evaluated with regard to their functionality in respect to medical devices. The risk and benefits of using alternative plasticizers should be evaluated case by case.

show abstract

Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the “Enhanced OECD Test Guideline no. 407”

Cited by 31 publications

References 18 publications

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Collaborative work on evaluation of ovarian toxicity 9) Effects of 2- or 4-week repeated dose studies and fertility study of di(2-ethylhexyl)adipate (DEHA) in female rats

Plasticizer concentration in cord blood cryopreserved with DMSO

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