Subacute Malaria Due toPlasmodium falciparumand the Role of Polymerase Chain Reaction

Loop-mediated isothermal amplification (LAMP) assay for the diagnosis of imported malaria: a narrative review

“…Although RDTs are rapid, easy to use and sensitive for P. falciparum, they lack sensitivity at low parasite density, fail to identify a large number of non-falciparum malaria, do not allow parasite quantification, are prone to some errors in reading and interpreting test lines and result in false negative malaria diagnosis when P. falciparum with Histidine Rich Protein 2 (HRP2)-deletion is involved [6,9,10,13]. At present, PCR represents the most sensitive and specific tool for the diagnosis of malaria, but its cost and turnaround time greatly limit its use outside of reference laboratories [11,[14][15][16]. Thus, blood microscopy and RDT remain the conventional methods used for malaria diagnosis in clinical practice.…”