Subacute inflammatory demyelinating polyradiculoneuropathy complicating relapsing Hodgkin lymphoma: another immune-related adverse event of the anti-PD1 therapy?

Barp, Andrea; Gilardin, Laurent; Afanasiev, Vadim; Delorme, Cécile; Bernard, Sophie; Brice, Pauline; Psimaras, Dimitri; Lenglet, Timothée

doi:10.1080/10428194.2018.1485912

Cited by 3 publications

(2 citation statements)

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“…The real incidence of peripheral neuropathy as adverse effect is unknown but patients with cranial, optic, and diffuse peripheral neuropathies have been reported. Moreover, subacute polyradiculoneuropathy has also been observed . Being relatively new drugs, specific data regarding the clinical features and the timing of onset and recovery of the neuropathy are still lacking …”

Section: Chemotherapy‐induced Neurotoxicitymentioning

confidence: 99%

“…Moreover, subacute polyradiculoneuropathy has also been observed. 125 Being relatively new drugs, specific data regarding the clinical features and the timing of onset and recovery of the neuropathy are still lacking. 105,117 Nelarabine, a purine nucleoside analogue used in lymphoblastic Tcell lymphoma, can cause severe neurotoxicity, mostly presenting with acute polyradiculoneuritis.…”

Section: Vinka Alkaloids (Vincristine Vinblastine Vinorelbine and mentioning

confidence: 99%

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Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

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The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune‐mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Some clinical findings, such a focal or diffuse involvement, symmetric or asymmetric pattern, presence of pain may point to the correct diagnosis. Besides a thorough medical history and neurological examination, neurophysiological studies, cerebrospinal fluid analysis, nerve biopsy (in selected patients with suspected lymphomatous infiltration) and neuroimaging techniques (magnetic resonance neurography and nerve ultrasound) may be crucial for a proper diagnostic workup.

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Section: Chemotherapy‐induced Neurotoxicitymentioning

confidence: 99%