The normal cellular metabolism can generate reactive oxygen species (ROS) from reactive molecules such as free radicals and molecular oxygen. Albeit free radicals have beneficial effects on various physiological functions at certain levels, such as immune defense and cell signaling processes, when the body's production of free radicals and antioxidants is out of balance, free radicals become harmful. With this instability, free radicals cause cellular and tissue damage and generate oxidative stress. Oxidative stress has gained