Subacute exposure to lead promotes disruption in the thyroid gland function in male and female rats

Lima, Niedson Correia de; Camilo, Juliana Franco; Carmo, Pâmella Rodrigues do; Andrade, Marcelle Novaes; Braz, Bernardo Ferreira; Santelli, Ricardo Erthal; Brito-Gitirana, Lycia de; Ferreira, Andrea Cláudia Freitas; Carvalho, Denise P.; Miranda-Alves, Leandro; Dias, Glaecir Roseni Mundstock

doi:10.1016/j.envpol.2020.115889

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…Children aged 0-6 years and persons aged ≥ 60 years were the most sensitive to lead exposure. We found that lead exposure had the highest DALY-PAFs in children aged 0-6 years, and that this group was more likely to develop MD, which is consistent with a previous study [36] and may be related to the fact that lead reduces thyroid hormone levels by lowering NIS and TSHr protein [37] and epidemiological studies have also shown that thyroid hormone deficiency affects cognitive development in children [38]. Additionally, a pregnant woman's exposure to lead puts her developing fetus at risk of neurodevelopmental defects because lead can cross the placental barrier [39].…”

Section: Discussionsupporting

confidence: 91%

Patterns of global burden of 13 diseases attributable to lead exposure, 1990–2019

Lin

Cao

et al. 2023

BMC Public Health

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Objectives Understanding the spatio-temporal patterns of the global burden of various diseases resulting from lead exposure is critical for controlling lead pollution and disease prevention. Methods Based on the 2019 Global Burden of Disease (GBD) framework and methodology, the global, regional, and national burden of 13 level-three diseases attributable to lead exposure were analyzed by disease type, patient age and sex, and year of occurrence. Population attributable fraction (PAF), deaths and disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) obtained from the GBD 2019 database were used as descriptive indicators, and the average annual percentage change (AAPC) was estimated by a log-linear regression model to reflect the time trend. Results and conclusions From 1990 to 2019, the number of deaths and DALYs resulting from lead exposure increased by 70.19% and 35.26%, respectively; however, the ASMR and ASDR decreased by 20.66% and 29.23%, respectively. Ischemic heart disease (IHD), stroke, and hypertensive heart disease (HHD) showed the highest increases in deaths; IHD, stroke, and diabetes and kidney disease (DKD) had the fastest-growing DALYs. The fastest decline in ASMR and ASDR was seen in stroke, with AAPCs of -1.25 (95% CI [95% confidence interval]: -1.36, -1.14) and -1.66 (95% CI: -1.76, -1.57), respectively. High PAFs occurred mainly in South Asia, East Asia, the Middle East, and North Africa. Age-specific PAFs of DKD resulting from lead exposure were positively correlated with age, whereas the opposite was true for mental disorders (MD), with the burden of lead-induced MD concentrated in children aged 0–6 years. The AAPCs of ASMR and ASDR showed a strong negative correlation with the socio-demographic index. Our findings showed that the global impact of lead exposure and its burden increased from 1990 to 2019 and varied significantly according to age, sex, region, and resulting disease. Effective public health measures and policies should be adopted to prevent and control lead exposure.

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Section: Discussionsupporting

confidence: 91%

Patterns of global burden of 13 diseases attributable to lead exposure, 1990–2019

Lin

Cao

et al. 2023

BMC Public Health

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“…Exposure of Cd to Rana zhenhaiensis decreased the size and epithelial thickness of thyroid follicles (Teng et al, 2022 ). Subacute exposure of Pb to mice impaired thyroid function by altering the protein expression of NIS and TSHr (de Lima Junior et al, 2021 ). A meta‐analyses study investigated the link between metal ions and TC.…”

Section: Factors That Affect Thyroid Functionmentioning

confidence: 99%

Exploring the oral‐gut microbiota during thyroid cancer: Factors affecting the thyroid functions and cancer development

Kun,

Xiaodong,

Haijun

et al. 2023

Food Science & Nutrition

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Thyroid cancer (TC) is categorized into papillary, follicular, medullary, and anaplastic. The TC is increasing in several countries, including China, the United States, the United Kingdom, Canada, France, Australia, Germany, Japan, Spain, and Italy. Thus, this review comprehensively covers the factors that affect thyroid gland function, TC types, risk factors, and symptoms. Lifestyle factors (such as nutrient consumption and smoking) and pollutants (such as chemicals and heavy metals) increased the thyroid‐stimulating hormone (TSH) levels which are directly related to TC prevalence. The conventional and recent TC treatments are also highlighted. The role of the oral and gut microbiota as well as the application of probiotics on TC are also discussed. The variations in the composition of oral and gut microbes influence the thyroid function indirectly through alteration in metabolites (such as short‐chain fatty acids) that are eminent for cellular energy metabolism. Maintenance of healthy gut and oral microbiota can help in regulating thyroid function by regulating iodine uptake. Oral or gut microbial dysbiosis can be considered as an early diagnosis factor or TC marker. High TSH during TC can increase the oral microbial diversity while disrupting the high ratio of Firmicutes and Bacteroidetes in the gut. Supplementation of probiotics as an adjuvant in TC treatment is beneficial. However, needs more extensive research to explore the direct effect of probiotics on thyroid function.

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Thyroid under siege: Unravelling the toxic impact of real-life metal mixture exposures in Wistar rats

Marić,

Baralić,

Vukelić

et al. 2024

Chemosphere

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Subacute exposure to lead promotes disruption in the thyroid gland function in male and female rats

Cited by 3 publications

References 67 publications

Patterns of global burden of 13 diseases attributable to lead exposure, 1990–2019

Patterns of global burden of 13 diseases attributable to lead exposure, 1990–2019

Exploring the oral‐gut microbiota during thyroid cancer: Factors affecting the thyroid functions and cancer development

Thyroid under siege: Unravelling the toxic impact of real-life metal mixture exposures in Wistar rats

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