Subacute dermal toxicity of perfluoroalkyl carboxylic acids: comparison with different carbon-chain lengths in human skin equivalents and systemic effects of perfluoroheptanoic acid in Sprague Dawley rats

Han, Ji-Seok; Jang, Sumi; Son, Hyeon-Taek; Kim, Yong-Bum; Kim, Younhee; Noh, Jung-Ho; Kim, Mi-Jeong; Lee, Byoung‐Seok

doi:10.1007/s00204-019-02634-z

Cited by 22 publications

(23 citation statements)

References 46 publications

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“…In fact, the concentration, repeat, and period of the exposure were to a great extent similar to those that may occur for the human skin. The measurements revealed that the production of MDA and the release of IL-1α have significantly increased in tissues treated with 2.5 mM PFASs compared with the control group whereas the level of 8-OHdG in the EpiDermFT skin model did not show any meaningful increase (Han et al, 2020). In a study on the immortal human skin keratinocyte (HaCaT) cells, however, exposure to 50 μM resulted in a remarkable growth of 8-OHdG-positive staining after a recovery period of 8 days (Peropadre et al, 2018).…”

Section: Dermal Exposure To Pfass and Immunotoxic Effectsmentioning

confidence: 90%

“…The potential of a chemical for inducing skin irritation and sensitization has a direct correlation with its capability of dermal penetration. Some evidence shows that some PFASs potentially are skin irritant and sensitizer (Kennedy, 1985;Gordon, 2011;Han et al, 2020). Moreover, synthesis and release of cytokines such as interleukin-1α (IL-1α) and interleukin-8 (IL-8), two appropriate parameters for screening chemicals for their sensitizing/irritating potential (Coquette et al, 2003), have been reported under exposure to PFASs, strongly suggesting dermal absorption and penetration of these chemicals (Han et al, 2020;Lunardi et al, 2016).…”

Section: Dermal Penetration and Absorption Of Pfassmentioning

confidence: 99%

“…Some evidence shows that some PFASs potentially are skin irritant and sensitizer (Kennedy, 1985;Gordon, 2011;Han et al, 2020). Moreover, synthesis and release of cytokines such as interleukin-1α (IL-1α) and interleukin-8 (IL-8), two appropriate parameters for screening chemicals for their sensitizing/irritating potential (Coquette et al, 2003), have been reported under exposure to PFASs, strongly suggesting dermal absorption and penetration of these chemicals (Han et al, 2020;Lunardi et al, 2016). Based on the abovementioned research on dermal penetration and absorption of PFASs, the dermal pathway is suggested to be a potential route of exposure to these chemicals.…”

Section: Dermal Penetration and Absorption Of Pfassmentioning

confidence: 99%

“…It is generally known that PFASs, especially longer-chain congeners, have a markedly potential for triggering inflammatory and oxidative reactions. Hue et al ( 2020) evaluated the levels of a pro-inflammatory factor (IL-1α) and two oxidative stress biomarkers, including malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) under topically dermal exposure to perfluoroalkyl carboxylic acids (PFCAs) with 5-8 carbons (Han et al, 2020). They used a human skin equivalent (HSE) model entitled EpiDerm Full Thickness (EpiDermFT) composed of constituents such as collagen and human fibroblasts and keratinocytes.…”

Section: Dermal Exposure To Pfass and Immunotoxic Effectsmentioning

confidence: 99%

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Exposure to per- and polyfluoroalkyl substances and premature skin aging

Mousavi

Delgado-Saborit

Godderis

2021

Journal of Hazardous Materials

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Per-and polyfluoroalkyl substances (PFASs) are a ubiquitous group of persistent chemicals distributed globally in the environment. Skin aging is a notorious process that is prematurely induced by the interaction between endogenous and exogenous factors, including exposure to environmental chemicals. The existing evidence suggests that skin absorption of PFASs through dermal contact may be an important route of exposure to these chemicals in humans. On the other hand, PFASs intake by other routes may lead to PFASs bioaccumulation in the skin via tissue bio-distribution. Additionally, the presence of PFASs in consumer and cosmetic products combined with their daily close contact with the skin could render humans readily susceptible to dermal absorption. Therefore, chronic low-dose dermal exposure to PFASs can occur in the human population, representing another important route of exposure to these chemicals. Studies indicate that PFASs can threaten skin health and contribute to premature skin aging. Initiation of inflammatory-oxidative cascades, induction of DNA damage such as telomere shortening, dysregulation of genes engaged in dermal barrier integrity and its functions, signaling of the mitogen activated protein kinase (MAPK) pathway, and last but not least the down-regulation of extracellular matrix (ECM) components are among the most likely mechanisms by which PFASs can contribute to premature skin aging.

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Section: Dermal Exposure To Pfass and Immunotoxic Effectsmentioning

confidence: 90%

Section: Dermal Penetration and Absorption Of Pfassmentioning

confidence: 99%

Section: Dermal Penetration and Absorption Of Pfassmentioning

confidence: 99%

Section: Dermal Exposure To Pfass and Immunotoxic Effectsmentioning

confidence: 99%

See 2 more Smart Citations

Exposure to per- and polyfluoroalkyl substances and premature skin aging

Mousavi

Delgado-Saborit

Godderis

2021

Journal of Hazardous Materials

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“…Among the PFASs, short-chain polyfluoroalkyl carboxylic acid (SC PFCA) and perfluorooctanoic acid (PFOA) are mostly detectable in polluted streams. Han et al (2020) has demonstrated the noxious effects of SC PCFA on the liver, testes and kidney through in vivo model. The study also reveals that PFOA also causes microscopic abnormalities and decreases the thickness of the skin.…”

Section: Non-stickmentioning

confidence: 99%

Assessment of Indian cooking practices and cookwares on nutritional security: A review

Saxena

Saini

Samtiya

et al. 2021

JANS

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Food provides us nutrients and the energy required for growth, reproduction, and maintenance. Energy is required to perform all voluntary and involuntary activities like digestion, respiration, circulation, carrying out professional, household and recreational activities. Despite having rich food diversity, we are using only a few items as our staple food. With the adoption of eastern cooking practices and cookwares, risk of both pre-and post-transitional diseases like diabetes, cardiovascular diseases, malnutrition, obesity, etc. has increased significantly. Aluminium toxicity and nutrients breakdown has become a common problem in pressure cooking. To overcome this problem, it is important to shift from the modernized cooking methods to our traditional cooking practices, i.e., use of earthen cookwares, clay pots and some selected metal utensils, e.g., copper, iron, brass, etc. It has been shown that earthen, copper, iron, and soapstone cookwares do not leach toxic trace elements into the food and enhance the sensory qualities without decreasing the food nutrients. Adoption of traditional Indian cooking practices (such as fermentation, roasting, germination, etc.), cookwares (such as earthen, copper, iron, soapstone, etc.) and increasing the consumption of healthy diet grains like millets, etc. can easily combat the pre- and post-transition health problems in India, effectively. This review would provide a deep understanding to the people to decide the best cookware and cooking processes that will improve their health and provide ample nutritional value to them.

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Preparation of fluorinated polysiloxane and its application in modified polyacrylates

Zhang,

2024

J of Applied Polymer Sci

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Polyacrylate materials are widely used in textile adhesives, functional finishing agents, architectural coatings, and other fields. In order to improve their hydrophobicity and flexibility, a novel fluorinated polysiloxane was prepared by acid catalyzed bulk ring opening reaction with octamethylcyclotetrasiloxane (D4), tetramethyltetravinylcyclotetrasiloxane (), and methyltrifluoropropylcyclotrisiloxane (), and its structure was characterized. Then, as a modified monomer, the fluorinated polysiloxane modified polyacrylates was prepared by miniemulsion polymerization. The effects of fluorinated polysiloxane monomers with different vinyl content and molecular weight on the properties of emulsion, film structure and film hydrophobicity were studied. The results showed that when using fluorinated polysiloxane monomer with Mn = 6235, vinyl content of 0.33 mmol/g, and fluorine content of 7.40 mmol/g for modification, the water contact angle on the surface of the adhesive film reached 100.4°, and the water absorption rate was 8.1%, resulting in the best effect. Used for textile printing, the color fastness to dry and wet friction after fabric printing could reach level 4, and the hand feel was soft.

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Subacute dermal toxicity of perfluoroalkyl carboxylic acids: comparison with different carbon-chain lengths in human skin equivalents and systemic effects of perfluoroheptanoic acid in Sprague Dawley rats

Cited by 22 publications

References 46 publications

Exposure to per- and polyfluoroalkyl substances and premature skin aging

Exposure to per- and polyfluoroalkyl substances and premature skin aging

Assessment of Indian cooking practices and cookwares on nutritional security: A review

Preparation of fluorinated polysiloxane and its application in modified polyacrylates

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