Subacute Cutaneous Lupus Erythematosus Induced by Chemotherapy

Wiznia, Lauren E.; Subtil, Antonio; Choi, Jennifer N.

doi:10.1001/jamadermatol.2013.4957

Cited by 38 publications

(27 citation statements)

References 21 publications

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“…postulated that drug‐induced photosensitivity has a major role in the aetiopathogenesis of DI‐SCLE, but photosensitivity induced by pazopanib is not described. Others have hypothesized that keratinocyte apoptosis caused by chemotherapeutic agents might lead to nucleosome release, and subsequently cause the autoimmune reaction, as it is proven that nucleosomes are important antigens in lupus pathogenesis . This theory could explain our case, considering that pazopanib induces apoptosis to produce its antiangiogenic effect…”

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confidence: 59%

“…Since drug‐induced subacute cutaneous lupus erythematosus (DI‐SCLE) was first described in 1985, a continually expanding list of medications has been associated with its development. In recent years, some conventional chemotherapeutic agents such as capecitabine, doxorubicin, gemcitabine and docetaxel have been added to the list . We describe a case of DI‐SCLE induced by the novel multikinase inhibitor pazopanib (Votrient ® ; GlaxoSmithKline, Brentford, U.K.).…”

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confidence: 99%

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Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib

et al. 2014

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confidence: 59%

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Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib

et al. 2014

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“…To the best of our knowledge, there is only one case report describing SCLE induced by gemcitabine [4]. …”

Section: Discussionmentioning

confidence: 99%

“…Since then, many other drugs, including several chemotherapeutic agents, have been related to SCLE [2,4]. To our knowledge, there is only one previous case report describing gemcitabine treatment as causative of SCLE [4]. Herein, we present another case report of SCLE related to monotherapeutic gemcitabine.…”

Section: Novel Insightsmentioning

confidence: 96%

“…In 1985, Reed et al [3] were the first to describe a series of 5 patients in whom hydrochlorothiazide was implicated as the causative factor. Since then, many other drugs, including several chemotherapeutic agents, have been related to SCLE [2,4]. To our knowledge, there is only one previous case report describing gemcitabine treatment as causative of SCLE [4].…”

Section: Novel Insightsmentioning

confidence: 99%

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Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report

Zvi¹,

Vaknine

Menczer

et al. 2016

Chemotherapy

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Subacute cutaneous lupus erythematosus (SCLE) is a rare eruption related to several pharmacological and chemotherapy agents. We present a 63-year-old female with recurrent epithelial ovarian cancer who developed SCLE after administration of gemcitabine. Following discontinuation of gemcitabine and after oral steroid treatment, all skin lesions disappeared. In view of the extensive use of gemcitabine in recurrent ovarian cancer, it is important to be aware of the possibility of SCLE occurrence in these patients.

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Subacute Cutaneous Lupus Erythematosus Induced by Mitotane

et al. 2016

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Discussion | Cystinosis is caused by the accumulation of free cystine within lysosomes. 1 Cystine is derived from protein degradation within the lysosome and is normally transported through the lysosomal membrane to the cytosol where it is transformed into cysteine and reused. 5 In cystinosis, a mutation in the CTNS gene (on chromosome 17p13), 6 which encodes cystinosin, leads to a defect in the transport system. The low solubility of cystine leads to the precipitation of intracellular needle-shaped crystals as lysosomal cystine levels rise. 3 The accumulation of cystine in various tissues in the body has been known to cause renal failure as well as extrarenal effects leading to ocular, hepatic, thyroid, pancreatic, muscular, dental, gonadal, and neurologic tissue damage. 1,3 However, we know of only 3 prior reports of cutaneous accumulation of cystine crystals in patients with cystinosis. The first 2 published reports described subcutaneous infiltration of a palpable amorphous material with skin atrophy and telangiectasia mimicking premature aging 2 and scattered small erythematous hyperkeratotic macules and papules on sunexposed areas. 3 The third published report involved normalappearing skin on the forearms of patients with infantile cystinosis examined with in vivo reflectance confocal microscopy. 4 To our knowledge, the present case report is the first to describe multiple skin-colored, dome-shaped, firm facial papules in a patient with long-term cystinosis. A definitive diagnosis of cystinosis can be made based on an elevated cystine content in peripheral blood leukocytes. 1 Early detection of cystinosis is crucial because early treatment with oral cysteamine improves growth and survival, prevents hypothyroidism, reduces ocular impairment, and can preserve renal function. 1 Given the improved prognosis for patients with cystinosis who receive renal transplantation and/or cysteamine therapy, the prevalence of extrarenal effects, including cutaneous manifestations, may become more apparent over time. Finally, examination of biopsy specimens under electron microscopy may be required to accurately diagnosis cutaneous cystinosis.

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Subacute Cutaneous Lupus Erythematosus Induced by Chemotherapy

Abstract: This case and a review of the literature call attention to gemcitabine and other chemotherapeutic agents that have been reported to cause drug-induced SCLE. We also discuss the clinical features of the disease.

Cited by 38 publications

References 21 publications

Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib

Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib

Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report

Subacute Cutaneous Lupus Erythematosus Induced by Mitotane

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