Subacute cutaneous lupus erythematosus associated with cilazapril

A systematic review of drug-induced subacute cutaneous lupus erythematosus

“…The median incubation time was 6 weeks. The mean and median overall time 30 3 cases Nitrendipine 31 1 case Diuretics Hydrochorothiazide 3,10,22 10 cases Hydrochlorothiazide + triamterene 6 3 cases Chlorthiazide 5 2 cases Beta blockers Oxprenolol 32 4 cases Acebutolol 33 1 case Angiotensin-converting enzyme inhibitors Enalapril 10 2 cases Lisnopril 10 1 case Captopril 34 1 case Cilazapril 34 1 case Antifungals 30 of 117 reported cases: 25AE6% Terbinafine 12,14-16, [35][36][37] 29 cases Griseofulvin 13 1 case Chemotherapeutics 10 of 117 reported cases: 8AE5% Docetaxel 38 3 cases Paclitaxel 24, 38 3 cases Tamoxifen 39 2 cases Capecitabine 40, 41 2 cases Antihistamines 9 of 117 reported cases: 7AE7% Ranitidine 42 7 cases Brompheniramine 42 1 case Cinnarizine + thiethylperazine 43 1 case Immunomodulators 8 of 117 reported cases: 6AE8% Leflunomide 9,17,25, 44 5 cases Interferon a and b 10, 45 3 cases Antiepileptics 3 of 117 reported cases: 2AE6% Carbamazepine 46, 47 2 cases Phenytoin 48 1 case Statins 3 of 117 reported cases: 2AE6% Simvastatin 10, 49 2 cases Pravastatin 10 1 case Biologics 2 of 117 reported cases: 1AE7% Etanercept 50 1 case Efalizumab 51 1 case Proton pump inhibitors 2 of 117 reported cases: 1AE7% Lansoprazole 52 2 cases Nonsteroidal anti-inflammatory drugs 2 of 117 reported cases: 1AE7% Naproxen 53 1 case Piroxicam 26 1 case Hormone-altering drugs 2 of 117 reported cases: 1AE7% Leuprorelin 19 1 case Anastrozole 18 1 case Ultraviolet therapy 2 of 117 reported cases: 1AE7% PUVA 54 1 case PUVA and UVB 20 1 case Others 4 of 117 reported cases: 3AE4% Bupropion…”

Acebutolol-Induced Subacute Cutaneous Lupus Erythematosus

“…The main other drugs associated with the disease are calcium channel blockers, captopril and sys- 3 Drugs reported in the literature to induce cases of lupus erythematosus Streptomycin, tetracycline, penicillin, oral contraceptives, griseofulvin, calcium channel blockers, captopril, interferon-␣, minocycline, interleukin-2, clonidine, antihistamines, proton pump inhibitors, infl iximab, amiodarone, hypolipemia drugs, para-aminosalicylic acid Table 2. Molecules reported with druginduced SCLE Thiazides [5,37] Nifedipine, verapamil, diltiazem [38] Captopril [39] Terbinafi ne [40,41], griseofulvin [42] D-Penicillamine [43] Piroxicam [43] Naproxen [43] Sulfonylureas [43] Oxprenolol [43] Aldactone [43] Cinnarizine [44] Cilazapril [45] Interferon-␤ [46] Ranitidine [47] Chrysotherapy [43] ( table 2 ). Beta-blocking agents are rarely associated with DILE.…”

Angiotensin‐converting enzyme inhibitors or angiotensin II receptor blockers and the risk of developing rheumatoid arthritis in antihypertensive drug users

“…To our knowledge, this is the first observational study investigating the influence of ACE inhibitor and ARB use and incident RA. Evidence for the association between ACE inhibitor and/or ARB use and the occurrence of autoimmune diseases was derived from case reports of lupus‐like disease, vasculitis, and pemphigus . In these case reports, the commonly prescribed ACE inhibitors such as captopril and enalapril were often reported as a suspected drug for the occurrence of these autoimmune diseases.…”

“…Otherwise, it has been postulated that the immunomodulating effects of ACE inhibitors may facilitate autoimmune responses . Indeed, several case reports have suggested that ACE inhibitors may facilitate the development of autoantibodies and autoimmune diseases such as lupus‐like syndrome, vasculitis, and pemphigus . Furthermore, one patient with ARB‐associated pemphigus has been reported …”