Subacute combined degeneration of the spinal cord with involvement of the anterior columns: a new MRI finding

Karantanas, A. H.; Markonis, A.; Bisbiyiannis, G

doi:10.1007/s002340050027

Cited by 42 publications

(22 citation statements)

References 11 publications

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“…This may be due to the fact that demyelination begins in the dorsal columns before it affects the lateral columns [20]. Although rare, involvement of the anterior column has also been reported in patients with SCD [21]. Of all our patients, 30 of them were found to have abnormal spinal cord MRI signals.…”

Section: Discussionmentioning

confidence: 83%

Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

Cao

et al. 2018

Eur Neurol

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Purpose: The study aimed to analyze the clinical characteristics, laboratory test results, neuroimaging findings, and outcomes in patients diagnosed with subacute combined degeneration (SCD). Materials and Methods: A total of 68 patients with SCD who had been appropriately treated for no less than 6 months were included in our study. Histories, results of routine blood tests, biochemical indices, serum vitamin B₁₂ levels, and spinal magnetic resonance imaging (MRI) findings from the patients were studied and analyzed. Clinical signs and symptoms, graded using a functional disability rating scale, were scored at the time of admission and 3 and 6 months after admission. Results: Limb numbness, limb weakness, and gait disturbances were the most common symptoms in patients with SCD. All patients showed clinical improvement to different degrees at the follow-up visits after vitamin B₁₂ treatment. No differences in rating score were found in patients grouped by sex, hemoglobin level, serum vitamin B₁₂, or MRI manifestations at the time of admission or at the follow-up visits. Younger patients and those with shorter disease courses had better rating scores at the short-term follow-up visits. Conclusion: Anemia, low levels of serum vitamin B₁₂, and MRI abnormalities in the spinal cord are not expected to be associated with worse clinical manifestations. The age of onset and course of disease are important in evaluating the short-term prognosis of patients with SCD.

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Section: Discussionmentioning

confidence: 83%

Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

Cao

et al. 2018

Eur Neurol

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“…Histopatolojik olarak; öncelikle miyelin kılıflarında şişme, miyelin içi vakuol oluşumu ve miyelin lamellerinde ayrılmalar ortaya çıkar. Patolojik süreç devam ederse miyelin dejenerasyonunu gliozis ve akson hasarı izlemektedir (16,17).…”

Section: Discussionunclassified

“…İntramedüller lezyonu olan olguların ayırıcı tanısında; demiyelinizan hastalıklar, infeksiyöz nedenler, inflamatuvar hastalıklar, neoplazmlar, Vitamin E eksikliği gibi metabolik hastalıklar, karsinömatöz radikülopati, arteriyel veya venöz iskemiler, radyasyon miyeliti yer almaktadır (17,27,28). Demiyelizan hastalıklarda lezyon genellikle iki vertebra aralığını geçmez ve postero-lateral yerleşimli olurken, SKD'deki lezyonlar sıklıkla arka kolumnada görüldüğü ve birkaç vertebra bölümünde uzanabildiği bilinmektedir (29)(30)(31)(32).…”

Section: Discussionunclassified

Vitamin B12 Eksikligine Bagli Subakut Kombine Dejenerasyon: Bir Olgu Nedeniyle Gozden Gecirme

2016

GMJ

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ÖZETVitamin B12 eksikliği; nöropati, myelopati, demans, nöropsikiyatrik bulgular ve optik nöropati ile presente olabilir. Subakut kombine dejenerasyon (SKD) olarak bilinen B12 vitamini eksikliğine bağlı spinal kord tutulumu, nörolojik bozuklukların %10'unu oluşturur. B12 eksikliğinin nöroloji pratiğinde sık görülmesi ve önemi nedeniyle, b12 vitamini eksikliğine bağlı reversibl spinal kord tutulumu olan bir olguyu, klinik ve görüntüleme bulguları ile birlikte ayrıntılı olarak gözden geçirerek sunduk. ABSTRACTVitamin B12 deficiency may present with neuropathy, myelopathy, dementia, neuropsychiatric disorders and optic neuropathy. Spinal cord involvement due to vitamin B12 deficiency that is known as subacute combined degeneration (SCD), creates 10% of the neurological disorders. Because of the relative frequency and importance of Vitamin B12 deficiency in neurological practice, we presented a detailed review of a case with reversible spinal cord involvement due to vitamin B12 deficiency, with the clinical and imaging features..

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“…Erken dönemde tanı konulup tedavi uygulanabilen durumlarda klinik ve radyolojik bulgularda tama yakın düzelme görülebilmektedir (8) . Vitamin B12 eksikliğinde spinal kord tutulumu, sıklıkla posterior ve lateral kolonlarda görülmekle birlikte ender olarak spinal kordun anterior bölgesinde de görülebilir (4,9) . …”

Section: Discussionunclassified

A Case Of Subacute Combined Degeneration: Atypical İnvolvement Of Anterior Columns

Özkan¹,

Gulluoglu²,

Karaman³

et al. 2016

Okmeydani Medical Journal

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Subacute combined degeneration of the spinal cord with involvement of the anterior columns: a new MRI finding

Cited by 42 publications

References 11 publications

Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

Subacute Combined Degeneration: A Retrospective Study of 68 Cases with Short-Term Follow-Up

Vitamin B12 Eksikligine Bagli Subakut Kombine Dejenerasyon: Bir Olgu Nedeniyle Gozden Gecirme

A Case Of Subacute Combined Degeneration: Atypical İnvolvement Of Anterior Columns

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