Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin

Demir, Filiz; Uzun, Fatma; Durak, Dilek; Kalender, Yusuf

doi:10.1016/j.pestbp.2010.11.002

Cited by 79 publications

(52 citation statements)

References 42 publications

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“…However, the majority of studies discuss the protective effect of vitamins or microelements following the exposure to organophosphate insecticides (Verma et al 2007, Demir et al 2011 or the influence of mixtures of pesticides (El-Demerdash 2011, Ojha and Srivastava 2012). In our study in the group with combined intoxication (i.e.…”

Section: Discussionmentioning

confidence: 93%

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Spodniewska¹,

Barski²,

Ziółkowski³

2014

Polish Journal of Veterinary Sciences

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The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD 50 for 5 consecutive days and pyrantel embonate (Group II) at a dose of 1/5 LD 50 for 3 consecutive days. The animals of group III were given both of the mentioned above compounds in the same manner as group I and II, but pyrantel embonate was applied on day 3, 4, and 5 from the beginning of dimethoate intoxication. Material from 6 rats randomly selected from each group was obtained after 3, 6 and 12 hours and 2, 7 and 14 days following the last applied dose of the compounds under study. It was found that application of pyrantel embonate caused only slight changes in the analysed parameters i.e. GSH, GPx and GR. Dimethoate administration caused disturbances in the antioxidative system manifested as a decrease in GSH concentration in the liver (max. -37.7% after 6 hours) and an increase of GPx and GR activities in erythrocytes (max. -21.7% and 29.6% after 3 hours, respectively), compared to the control group. The profile of changes after combined intoxication was similar, but their intensity was higher compared to the group of animals exposed to dimethoate only. Based on current studies, it was concluded that both dimethoate and pyrantel embonate at the applied doses showed a pro-oxidative activity.

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Section: Discussionmentioning

confidence: 93%

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Spodniewska¹,

Barski²,

Ziółkowski³

2014

Polish Journal of Veterinary Sciences

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“…This increase in MDA levels could be due to an increase in free radicals, resulting from the induction of oxidative stress. Mammalian cells possess non-enzymatic and enzymatic antioxidant defense systems to prevent the oxidative stress that interact with and inactivate ROS (Farmand et al 2005;Demir et al 2011). SOD plays an important role in protecting the toxic effects of superoxide radical (Xia et al 2010;Uzunhisarcıklı and Kalender 2011) and catalyzes the conversion of superoxide radicals to hydrogen peroxide ).…”

Section: Discussionmentioning

confidence: 99%

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Apaydın

Kalender

Baş

et al. 2014

Braz. arch. biol. technol.

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“…Research continues to be conducted to find a way to reduce the oxidative stress responsible for the pathogenesis of OP compounds. For this purpose, an anti-inflammatory agent such as rosiglitazone [25], antioxidants agents such as vitamin C [23], N-acetylcystein [26], melatonin [27], quercetin [8], pomegranate, and rutin [28] have been reported as the attenuating agents for CPF induced toxicity.…”

Section: Histopathological Evaluationmentioning

confidence: 99%

“…Toxic clinical signs induced by OP poisonings may also develop through the occurrence of oxidative stress [5,6]. Several studies have reported that OP compounds may cause various organ injuries and oxidative stress [3,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats

Dokuyucu¹,

Bilgili²,

Hanedan³

et al. 2016

Med Pr

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Background: Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats. Material and Methods: The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 µmol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed. Results: Chlorpyrifos statistically significantly decreased the TAC levels in the rats' plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels. Conclusions: This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis. Med Pr 2016;67(6):743-749

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Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin

Cited by 79 publications

References 42 publications

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats

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