Subacromial bursa increases the failure force in a mouse model of supraspinatus detachment and repair

The effect of augmenting suture material with magnesium and platelet-rich plasma on the in vitro adhesion and proliferation potential of subacromial bursa-derived progenitor cells

“…Recently, the use of connective tissue progenitor cells derived from SBDCs has come to the fore as an easily accessible, inexpensive, and highly potent biologic augment in the setting of arthroscopic rotator cuff repair. 3 , 9 , 17 , 22 , 24 , 26 , 35 , 36 , 39 More specifically, Morikawa et al found that SBDCs had superior differentiation and proliferation potential compared to concentrated bone marrow aspirate and proposed a feasible method for isolating SBDCs for clinical use. 22 , 24 Interestingly, SBDCs were shown to have a high cellular proliferation potential regardless of patient demographics, rotator cuff tear characteristics, or severity of glenohumeral joint degeneration, alleviating concerns that SBDCs may lose biologic activity in the setting of massive and degenerated rotator cuff tears.…”

Translational Research on Orthobiologics in the Treatment of Rotator Cuff Disease: From the Laboratory to the Operating Room

“…These cells also exhibited the ability to grow out 115 ± 29 colony forming units per 1 mL media 29 . In addition, when applied to a mouse model of RCR, the application of subacromial bursa-derived cells to the RCR site resulted in superior biomechanical properties at 2 and 4 weeks 30 . In addition, tissue-specific endothelial cells or intrinsic tissue-specific resident progenitor cells may have utility in secreting signaling molecules that help stimulate repair and/or to induce tissue regeneration 10,31 …”

“…29 In addition, when applied to a mouse model of RCR, the application of subacromial bursa-derived cells to the RCR site resulted in superior biomechanical properties at 2 and 4 weeks. 30 In addition, tissue-specific endothelial cells or intrinsic tissue-specific resident progenitor cells may have utility in secreting signaling molecules that help stimulate repair and/or to induce tissue regeneration. 10,31 Finally, in addition to cell-based therapies for tendonspecific healing, cell-based strategies have also been utilized for the treatment of the associated muscle pathologic changes that occur in the setting of rotator cuff tears.…”

Orthobiologics: Current Status in 2023 and Future Outlook

“…22 Preclinical studies demonstrate a positive effect of these cells on rotator cuff tendon repair. 23 Another approach is stimulation of intrinsic progenitor cells (“stem cell niche”) that reside in capillary walls and are termed pericytes. Contemporary understanding is that these intrinsic tissue-specific resident stem cells are stimulated by the bioactive factors and signaling molecules secreted by exogenously supplied MSCs.…”