Sub-strains of Drosophila Canton-S differ markedly in their locomotor behavior

Colomb, Julien; Brembs, Björn

doi:10.12688/f1000research.4263.1

Cited by 40 publications

(30 citation statements)

References 17 publications

(10 reference statements)

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“…Developmental nicotine exposure increased ethanol sedation in w B, but had no effect in EY5 flies at the nicotine and ethanol concentrations tested. Studies have shown that genetic background can have an effect on behaviors such as locomotion, sleep, and sensitivity to anesthetics [51–53]. The contrasts we found are likely due to differences in genetic background.…”

Section: Resultscontrasting

confidence: 50%

A Drosophila model for developmental nicotine exposure

Velazquez-Ulloa

2017

PLoS ONE

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Despite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood. Drosophila melanogaster is a model organism that can be used for uncovering genetic and molecular mechanisms for drugs of abuse. Here I show that Drosophila can be a model to elucidate the mechanisms for nicotine’s effects on a developing organism. Drosophila reared on nicotine food display developmental and behavioral effects similar to those in mammals including decreased survival and weight, increased developmental time, and decreased sensitivity to acute nicotine and ethanol. The Drosophila nicotinic acetylcholine receptor subunit alpha 7 (Dα7) mediates some of these effects. A novel role for Dα7 on ethanol sedation in Drosophila is also shown. Future research taking advantage of the genetic and molecular tools for Drosophila will allow additional discovery of the mechanisms behind the effects of nicotine during development.

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Section: Resultscontrasting

confidence: 50%

A Drosophila model for developmental nicotine exposure

Velazquez-Ulloa

2017

PLoS ONE

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“…8 Several studies have shown that genetic background has a strong effect on behavior in Drosophila, [9][10][11][12] and a common strategy to overcome this problem is to outcross mutations to the same genetic background. Yet, selection of which genetic background to use can itself be problematic, because these are likely to influence the behavioral phenotype being studied.…”

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confidence: 99%

Behavioral and electrophysiological analysis of general anesthesia in 3 background strains ofDrosophila melanogaster

Zalucki

Day

Kottler

et al. 2015

Fly

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General anesthetics achieve behavioral unresponsiveness via a mechanism that is incompletely understood. The study of genetic model systems such as the fruit fly Drosophila melanogaster is crucial to advancing our understanding of how anesthetic drugs render animals unresponsive. Previous studies have shown that wild-type control strains differ significantly in their sensitivity to general anesthetics, which potentially introduces confounding factors for comparing genetic mutations placed on these wild-type backgrounds. Here, we examined a variety of behavioral and electrophysiological endpoints in Drosophila, in both adult and larval animals. We characterized these endpoints in 3 commonly used fly strains: wild-type Canton Special (CS), and 2 commonly used white-eyed strains, isoCJ1 and w 1118 . We found that CS and isoCJ1 show remarkably similar sensitivity to isoflurane across a variety of behavioral and electrophysiological endpoints. In contrast, w 1118 is resistant to isoflurane compared to the other 2 strains at both the adult and larval stages. This resistance is however not reflected at the level of neurotransmitter release at the larval neuromuscular junction (NMJ). This suggests that the w 1118 strain harbors another mutation that produces isoflurane resistance, by acting on an arousal pathway that is most likely preserved between larval and adult brains. This mutation probably also affects sleep, as marked differences between isoCJ1 and w 1118 have also recently been found for behavioral responsiveness and sleep intensity measures.

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“…Separate from updating reviews, there has been considerable discussion of methods for creating and managing 'living' systematic reviews that can extend their period of relevance by incorporating new research as it is published [74]. For example, a paper on Drosophila walking mechanisms published in the journal F1000 Research [75] employed the use of an updatable online figure that has been modified since publication to include more recent research [76]. There exist many significant challenges to establishing a living systematic review or systematic map.…”

Section: Knowledge Glutsmentioning

confidence: 99%

What are the effects of agricultural management on soil organic carbon in boreo-temperate systems?

et al. 2015

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Background: Soils contain the largest stock of organic carbon (C) in terrestrial ecosystems and changes in soil C stocks may significantly affect atmospheric CO 2 . A significant part of soil C is present in cultivated soils that occupy about 35 % of the global land surface. Agricultural intensification has led to practices that may decrease soil organic carbon (SOC), and agricultural management has the potential to be a powerful tool for climate change mitigation and increased soil fertility through SOC sequestration. Here, we systematically map evidence relating to the impacts of agricultural management on SOC in arable systems of the warm temperate and snow climate zones (subset of temperate and continental climates: Köppen-Geiger Classification). Methods:Seventeen academic citation databases, 3 search engines and 25 organisational websites were searched for literature (academic and grey) using search strings translated into a range of languages relevant to the included geographical scope of the topic. Stakeholders were also contacted with requests for evidence. Bibliographic checking of 127 relevant reviews was undertaken to check for missing articles. Screening for relevance against predefined inclusion criteria was undertaken at title, abstract and full text levels according to a published protocol. All relevant studies were coded in a meta-database describing the citation, study settings, methods and quantitative data available (without extraction of the study findings). A basic critical appraisal of included studies was also performed. A geographical information system (GIS) presenting the map database on a physical, online map was also produced.Results: A total of 735 studies from 553 articles was included in the systematic map database. Studies investigated one or more of five broad categories of interventions: amendments (286 studies), crop rotations (238), fertilisers (307), tillage (306), and multiple interventions (55). Studies were identified from across the includible climate zones, with the notable underrepresentation from Russia. The majority of studies employed only point sampling of SOC, low levels of true spatial replication and moderate study periods (i.e. 10-20 years). Missing key methodological information was found in 28 % of studies. Conclusions: Long-term study sites identified in this map provide a useful addition to existing databases of longterm experiments (LTEs). The identification of knowledge gaps, such as studies from Russia, also identify a need for improved cataloguing or reporting of existing and on-going research. This systematic map database represents a useful resource for decision-makers wishing to identify knowledge gaps warranting further primary research, knowledge gluts warranting further secondary research, and deficiencies and best practice in research methodology. In addition to the systematic map database, we have also produced two further resources: (1) a database of LTE sites investigating agricultural management and SOC, and (2) a database of reviews a...

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Sub-strains of Drosophila Canton-S differ markedly in their locomotor behavior

Cited by 40 publications

References 17 publications

A Drosophila model for developmental nicotine exposure

A Drosophila model for developmental nicotine exposure

Behavioral and electrophysiological analysis of general anesthesia in 3 background strains ofDrosophila melanogaster

What are the effects of agricultural management on soil organic carbon in boreo-temperate systems?

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