Sub-chronic toxicological studies of transition metal complexes of naproxen on sprague-dawley rats

Abstract

Sub-chronic toxicological studies of transition metal complexes of naproxen on sprague-dawley rats,

Synthesis of Naproxen Esters and Evaluation of their In vivo and In silico Analgesic and Anti-inflammatory Activities

“…12 Therefore, improvement of the potency and efficacy of naproxen via derivatization chemical modification is an important task. To increase the pharmacological activity, physicochemical properties as well as to reduce the potential toxicity, we synthesized several metal complexes of naproxen and other NSAIDs earlier [13][14][15][16][17][18] and we found better pharmacological, toxicological and physicochemical properties of the synthesized derivatives in some instances. 14,17,18 As ester prodrugs are found to be beneficial in terms of efficacy and safety in many cases, 19 our continued interest in this topic directed us to synthesize some ester derivatives of naproxen to evaluate and compare their pharmacological activity and toxicity with parent drug.…”

“…To increase the pharmacological activity, physicochemical properties as well as to reduce the potential toxicity, we synthesized several metal complexes of naproxen and other NSAIDs earlier [13][14][15][16][17][18] and we found better pharmacological, toxicological and physicochemical properties of the synthesized derivatives in some instances. 14,17,18 As ester prodrugs are found to be beneficial in terms of efficacy and safety in many cases, 19 our continued interest in this topic directed us to synthesize some ester derivatives of naproxen to evaluate and compare their pharmacological activity and toxicity with parent drug. Herein, we disclose the synthesis of the naproxen esters along with their in vivo analgesic and anti-inflammatory efficacy as well as in silico binding mechanism against potential target protein for the above activity.…”