Sub-chronic toxicity studies of the Aqueous Leaf Extract of Rauvolfia Vomitoria (Afzel)

Amole, O.O.; Izegbu, MC

doi:10.4314/njhbs.v6i1.11613

Cited by 4 publications

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“…It belongs to the family Apocynaceae and grow to a height of about 15 m. It is commonly known as a Swizzle stick and known locally among Yorubas as "Asofeyeje", Igbos as "Ira" and Hausas as "Wadda" [11]. Traditionally, the plant is used in the treatment of high blood pressure, fever, general weakness, intestinal diseases, liver problems, mental illness, impotency, haemorrhoids and rheumatisms [12,13]. Rauwolfia vomitoria is a good source of therapeutically active alkaloids and about 200 alkaloids have so far been reported from Rauwolfia species [14]; alkaloids of pharmacological interests include ajmaline and ajmalicine [15] while reserpine which is another alkaloid has been known to be its active principle [15].…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic Potentials of Methanolic Extract of Rauvolfia vomitoria Leaves in Rats Fed with High Cholesterol

Owoade

Adetutu

Ogundipe

et al. 2021

APRJ

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The study was aimed to investigate the hypolipidemic potential of methanolic extract Rauvolfia vomitoria leaves in high cholesterol-fed rats. The preliminary study showed that R. vomitoria leaves were able to scavenge the 2,2-azino-bis (3-ethylbenzthiazoline-6-sufonic acid) (ABTS) and 2-Diphenyl-1- picrylhydrazyl (DPPH) radicals and these radicals scavenging abilities were found to be dose-dependent. Administration of cholesterol to rats for 45 days induced a significant increase in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and increase lipids levels in the plasma and tissues while HDL cholesterol was decreased. It also elevated the levels of malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activities in the tissues. However, co-administration of high cholesterol-fed rats with R. vomitoria extract at doses of 100 and 200 mg/kg significantly reversed lipids levels to near normal with cholesterol in the plasma, liver, heart, kidney and lung reduced by (23.13% and 56.43%), (30.09% and 20.90%), (38.21% and 74.53%), (12.61% and 32.49%) and (37.11% and 29.90%) respectively while HDL cholesterol level was increased by (225.44% and 110.39%). The levels of AST, ALT and ALP in the plasma and MDA in the tissues were also decreased while SOD activities in the liver, heart, kidney and lung were elevated by (89.35% and 149.21%), (74.91% and 68.35%), (56.76% and 114.77%), and (204.91% and 274.62%) respectively. The extract of R. vomitoria was found to be rich in phenolic content and was proved to have no toxic effects on rats when administered alone to normal rats at a dose level of 200mg/kg/day. The results obtained in this study demonstrated the antioxidant and lipid-lowering effects of R. vomitoria and, suggests that the plant could serve as a new potential natural product for the treatment of hyperlipidemia.

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Section: Introductionmentioning

confidence: 99%

Hypolipidemic Potentials of Methanolic Extract of Rauvolfia vomitoria Leaves in Rats Fed with High Cholesterol

Owoade

Adetutu

Ogundipe

et al. 2021

APRJ

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“…Reports show that this herb lowers blood pressure [2] and possesses analgesic, haematinic, and anticonvulsant properties [3][4][5]. Antioxidant and antipsychotic properties have also been reported [6,7], with another study reporting improvement of immunity [8].…”

Section: Introductionmentioning

confidence: 99%

Teratogenic Effects of Crude Ethanolic Root Bark and Leaf Extracts of Rauwolfia vomitoria (Apocynaceae) on the Femur of Albino Wistar Rat Fetuses

Eluwa

Ekanem

Udoh

et al. 2013

Journal of Histology

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Introduction. Rauwolfia vomitoria is a plant used as a sedative and in the treatment of psychotic tendency. This study was on the teratogenic effects of its root bark and leaf extracts on Wistar rat's fetal femurs. Materials and Methods. Twenty-five female rats weighing between 180 and 200 g were divided into 5 groups, of 5 rats each. Group A was the control, while Groups B, C, D, and E were the experimental. The female rats were mated with mature male rats to allow for pregnancy. Groups B and C animals received orally 150 mg/kg each of the root bark and leaf extracts of Rauwolfia vomitoria, respectively, while Groups D and E animals received 250 mg/kg bodyweight each of the root bark and leaf extracts of Rauwolfia vomitoria, respectively, from day 7 to day 11 of gestation. On day 20 of gestation, the rats were sacrificed, the fetuses were examined, and their femurs were dissected out and preserved, decalcified, and routinely processed using the Haematoxylin and Eosin staining method. Results. Histological observations of the fetal femur bones showed numerous osteoblast and osteoclast, hypertrophy, and hyperplasia of bone cells compared with the control. Conclusion. Ethanolic root bark and leaf extracts of Rauwolfia vomitoria may lead to advanced skeletal development.

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“…Rauvolfia vomitoria Afzel Apocynaceae UHAE B038 Leaves for treating yellow fever, internal pains, gastroenteritis, constipation and mental disorder. It is useful in the lowering of blood pressure (Amole, 2003), as an antimalarial (Amole et al, 1993). It also analgesic (Amole et al, 2006).…”

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confidence: 99%

Comparative phytochemical and ethnomedicinal survey of selected medicinal plants in Nigeria

Omotayo¹

2012

Sci. Res. Essays

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Phytochemical screening and ethnomedicinal survey of twenty-two medicinal plants distributed in fifteen different families were carried out in order to know the distribution of secondary metabolites and the diseases being treated with these plants. It was discovered that alkaloids, tannins and saponin were present in all. Flavonoid was absent only in Peperomia pellucida; five out of these plants lack terpene, ten of them have steroid; eleven of them have cardiac glycosides while only four of these twenty-two have phlobatannin. The ethnomedicinal survey revealed a wide range of human ailments being treated with these plants, ranging from eye infections, respiratory infections, inflammations, urinary diseases, jaundice, anaemia, arthritis to diabetes and dysentery. This study therefore, justifies the ethnobotanical significance of the plants by the presence of secondary metabolites, which if extracted, can be of significant medicinal usefulness in the synthesis of bioactive drugs. Therefore, the findings of this study are recommended for further screening to identify specific photochemical compounds of medicinal significance for bioprospecting and pharmaceutical production.

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Sub-chronic toxicity studies of the Aqueous Leaf Extract of Rauvolfia Vomitoria (Afzel)

Cited by 4 publications

References 0 publications

Hypolipidemic Potentials of Methanolic Extract of Rauvolfia vomitoria Leaves in Rats Fed with High Cholesterol

Hypolipidemic Potentials of Methanolic Extract of Rauvolfia vomitoria Leaves in Rats Fed with High Cholesterol

Teratogenic Effects of Crude Ethanolic Root Bark and Leaf Extracts of Rauwolfia vomitoria (Apocynaceae) on the Femur of Albino Wistar Rat Fetuses

Comparative phytochemical and ethnomedicinal survey of selected medicinal plants in Nigeria

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