Sub-chronic oral toxicity of Cuminum cyminum L.’s essential oil in female Wistar rats

Taghizadeh, Mohsen; Ostad, Seyed Naser; Asemi, Zatollah; Mahboubi, Mohaddese; Hejazi, Sara; Sharafati-Chaleshtori, Reza; Rashidi, Aliakbar; Akbari, Hosein; Sharifi, Nasrin

doi:10.1016/j.yrtph.2017.06.007

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…Cuminum cyminum L. Repeated oral administration in female Wistar rats of 1000 mg/kg/d of C. cyminum essential oil after the 23-day interval causes an increase in serum alanine transaminase levels (Taghizadeh et al, 2017).…”

Section: Species Toxicitymentioning

confidence: 99%

Ethnobotanical and ethnopharmacological study of medicinal plants used in the treatment of anemia in the region of Haouz-Rehamna (Morocco)

Benkhnigue¹,

Chaachouay²,

Khamar³

et al. 2022

J Pharm Pharmacogn Res

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Context: The ethnobotanical study of the plants used is of great interest in the medical field. In this perspective, we have carried out this ethnobotanical and ethnopharmacological study, which is part of the development of plant resources traditionally used against anemia in a large region of Middle Atlantic Morocco (Mam-4): Al Haouz-Rehamna. Aims: To establish a catalog of medicinal plants used in traditional medicine against anemia disease. Methods: For this purpose, we carried out an ethnobotanical survey using 1700 questionnaire cards during five campaigns (from 2012 to 2017) in the studied field. In addition, the information sought was about the plant including its local name, its part used, its toxicity and, medical practices related. Ethnobotanical indices, such as Use Value (UV), Family Use Value (FUV) and, Plant Part Value (PPV), were determined. Results: The results allowed us to identify 48 medicinal plants of which 12 were toxic. The inventoried species were distributed in 45 genera and belong to 27 botanical families, of which four predominated in the number of species: Apiaceae, Amaranthaceae, Fabaceae, and Asteraceae. Also, 11 species were traditionally more used as effective plants against anemia: Rubia peregrina, Lens culinaris, Malva sylvestris, Beta vulgaris, Spinacia oleracea, Mercurialis annua, Hibiscus sabdariffa, Corrigiola telephiifolia, Nasturtium officinale, Cistus laurifolius and Armeria mauritanica. The leafy stems were the most used part (PPV = 0.28%) followed by the seed (PPV = 0.26%). These parts were usually used steamed, decocted, and rarely triturated in honey or infused in water. The recipes were administered orally until cured. Conclusions: The present study established the importance of documenting traditional knowledge about the species of medicinal plants that are used to correct many chronic diseases such as anemia. Analysis of this knowledge has shown that several of the listed plants promoted anti-anemia activity and could become the basis for in-depth scientific investigations.

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Section: Species Toxicitymentioning

confidence: 99%

Ethnobotanical and ethnopharmacological study of medicinal plants used in the treatment of anemia in the region of Haouz-Rehamna (Morocco)

Benkhnigue¹,

Chaachouay²,

Khamar³

et al. 2022

J Pharm Pharmacogn Res

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“…Cumin is also labeled as a safe food ingredient having various pharmacological attributes. Taghizadeh et al (2017) examined the sub‐chronic oral toxicity of different doses (0, 250, 500, and 1,000 mg kg −1 day −1 ) of the CEO in female Wistar rats after 23 and 45 days of intervention. They observed no ill effect of CEO on clinical signs, mortality, body weight, hematology, biochemistry, and organs (liver, kidneys, spleen, and lungs) histology except enhanced serum levels of alanine transaminase (ALT) at a dose of 1,000 mg kg −1 day −1 .…”

Section: Toxicological Studiesmentioning

confidence: 99%

A review on traditional uses, phytochemistry, pharmacology, and clinical research of dietary spice Cuminum cyminum L.

Singh

Kumar

Narasimhan

2021

Phytotherapy Research

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Cuminum cyminum L. is a versatile spice belonging to family Apiaceae. Though the plant has pan‐tropical distribution but it is indigenous to Egypt, the Mediterranean, and South Asian countries. It exhibits numerous culinary, traditional, and pharmacological attributes. Its traditional uses also validate its immense pharmacological potential. Cuminum cyminum is the hub of numerous bioactives such as alkaloids, flavonoids, terpenoids, and so forth. Cuminaldehyde is the major bioactive, rendered to most of its pharmacological as well as clinical significance. The present study comprised of current knowledge on its taxonomy, nutritional, traditional, phytochemistry, pharmacology (antimicrobial, antioxidant, anti‐inflammation, antidiabetic, wound healing, anticancer, etc.), toxicology, and clinical attributes. Besides, the mechanism of action is also well explained. The present study provides a rationale for further bioprospection of this wonder plant. Future studies are needed to fill the research gaps, particularly on relevant phytocompound isolation, their pre‐clinical and clinical characterization, evaluation, and structure–activity relationship. Moreover, well‐designed and highly appropriate clinical and placebo trials are still needed to demonstrate the trustworthy role of cumin on human health.

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“…These findings are supported by another study in which administration of cumin seed powder capsule was reported to lower down the serum cholesterol as well as serum insulin level in diabetes Type-II suffering patients [25]. In another study, overweight patients showed a reduced level of serum TC, TG, and LDL-C [26]. Methanolic extract of cumin seed has been reported to exhibit the hypolipidemic effect in rats [27].…”

Section: Discussionmentioning

confidence: 55%

Protective Effect of Cumin (Cuminum Cyminum L.) Seed Extract on Cardiovascular System, Toxicity, and Hematology on Hyperlipidemic Rabbits: An Experimental Study

Chouhan

2018

Asian J Pharm Clin Res

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Objective: The present study is related with the assessment of anti-atherosclerotic efficacy of 70% EtOH extract of cumin seed in diet-induced hyperlipidemic rabbits.Methods: Rabbits were rendered hyperlipidemic by oral administration of cholesterol for 15 days. Then, the animals were treated with 70% EtOH (ethanolic extract) of cumin seed extract for 45 days (Group III). Another set of animals was treated with atorvastatin, the standard drug for 45 days. At the end of experimental period, the serum biochemical, hematological, and histological analysis of thoracic aorta was done.Results: The cumin seed extract showed contain hypolipidemic effect by reducing plasma cholesterol, low-density lipoproteins, and triglycerides level. While toxicological studies suggest no adverse effect on renal and liver function tests, hematological parameters were also observed in a normal range. Histological analysis showed that cholesterol administration caused a narrowing of the aortal lumen while treatment with 70% EtOH and atorvastatin decreased the plaque size and restored the luminal size of the aorta to normal.Conclusion: The present study suggests that commonly used culinary spice cumin seed possesses hypolipidemic and cardioprotective effect with a positive effect on serum biochemistry, histology, and hematology.

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Sub-chronic oral toxicity of Cuminum cyminum L.’s essential oil in female Wistar rats

Cited by 22 publications

References 11 publications

Ethnobotanical and ethnopharmacological study of medicinal plants used in the treatment of anemia in the region of Haouz-Rehamna (Morocco)

Ethnobotanical and ethnopharmacological study of medicinal plants used in the treatment of anemia in the region of Haouz-Rehamna (Morocco)

A review on traditional uses, phytochemistry, pharmacology, and clinical research of dietary spice Cuminum cyminum L.

Protective Effect of Cumin (Cuminum Cyminum L.) Seed Extract on Cardiovascular System, Toxicity, and Hematology on Hyperlipidemic Rabbits: An Experimental Study

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