Sub-Chronic Cerebrolysin Treatment Attenuates the Long-lasting Behavioral Alterations Caused by Maternal Separation in Rats

Sanchez-Olguin, Claudia P.; Guzmán-Velázquez, Sonia; Melo, Angel I.; Flores, Gonzalo; de-la-Cruz, Fidel; Zamudio, Sergio

doi:10.3923/ijp.2014.406.417

Cited by 2 publications

(6 citation statements)

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“…The ASR can be modulated by various stimulus conditions; two of them are PPI and habituation (Shoji & Miyakawa, 2018). Here, we used the paradigm of short‐term habituation of the ASR in which the decay of the startle amplitude after reiterated stimulation arises within a single test session (Flores‐Páez et al., 2020; Koch & Schnitzler, 1997; Sánchez‐Olguin et al., 2014). This type of habituation may occur within the primary ASR circuitry and not through the participation of more rostral brain structures (Leaton et al., 1985; Pilz & Schnitzler, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…The individual startle responses were calculated as the average of 10 pulses. The PPI percentage was calculated as the difference between the ASR trials and the respective PPI trial divided by the ASR trial multiplied by 100 (Bhardwaj et al., 2012; Sánchez‐Olguin et al., 2014). The startle apparatus was wiped with a detergent solution and alcohol between the tests of each animal.…”

Section: Methodsmentioning

confidence: 99%

“…The pups remained under this condition until PND 23 when they were weaned and housed two per cage until adulthood. At PND 90–100, females of each surgical treatment group were designated to one of two subgroups: Experiment (1) nVHL ( n = 8) and Sham ( n = 8) naïve females were tested for locomotor activity, dorsal immobility, social interaction toward a conspecific, PPI, and habituation of the ASR (Becker et al., 1999; Flores, Silva‐Gómez, Barbeau, et al., 2005; Flores, Silva‐Gómez, Ibáñez, et al., 2005; Lipska, Swerdlow, et al., 1995; Sánchez‐Olguin et al., 2014; Vazquez‐Roque et al., 2012). Experiment (2) nVHL ( n = 12) and Sham ( n = 9) naïve females were mated with a sexually expert male and were returned to the animal housing facility until parturition.…”

Section: Methodsmentioning

confidence: 99%

“…For all the measures of the startle response, the subject's mass was subtracted from the peak amplitude values. ASR and PPI were measured as reported previously (Ralph‐Williams et al., 2003; Sánchez‐Olguin et al., 2014; Vazquez‐Roque et al., 2012; Vinkers et al., 2007). Each experimental session consisted of baseline pulses, nonstimulus trials, startle trials, and prepulse trials; a background noise of 65 dB was present throughout the session.…”

Section: Methodsmentioning

confidence: 99%

“…This test was modified from Sánchez‐Olguin et al. (2014). Briefly, animals were placed in the startle chamber of the Responder‐X system for a 5 min acclimation period with a 65 dB background noise; then, 200 stimulating pulses (120 dB, 30 ms) were applied every 15 s and the ASR magnitudes were measured as described above, by averaging the data of each 20 consecutive responses (Flores‐Páez et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

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Neonatal ventral hippocampus lesion disrupts maternal behavior in rats: An animal model of schizophrenia

Sanchez-Olguin

Zamudio

Guzmán-Velázquez

et al. 2022

Developmental Psychobiology

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Although individuals with schizophrenia typically present deficits in social interaction, little is known about the quality of their parent–infant interactions. In the present study, we assessed the behavioral effects of neonatal ventral hippocampus lesion (nVHL) in female rats (nVHL is known to induce schizophrenia‐like deficits in males). Sexually naïve adult nVHL or sham female rats received cognitive and social tests, and their maternal behavior was observed in independent groups of adult nVHL and sham rats on postpartum days 2, 6, and 12. Compared to Sham females, naïve nVHL rats displayed elevated locomotor activity, less social interaction, and disrupted habituation of the acoustic startle response (ASR), while dorsal immobility (a defensive behavioral response) and prepulse inhibition of ASR were not affected. Although all nVHL mothers retrieved their pups, adopted the crouching posture, and nursed them, they showed disturbances in the display of pup body licking and nest building. Furthermore, a high proportion of nVHL mothers displayed atypical retrieval of pups and re‐retrieving of pups, atypical nest‐building, excavation, and cannibalism, as well a high level of these behaviors. These data indicate that cognition, locomotor activity, and maternal care is disrupted in nVHL female, suggesting disturbances in mesocorticolimbic dopaminergic systems and/or in social cognition.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Neonatal ventral hippocampus lesion disrupts maternal behavior in rats: An animal model of schizophrenia

Sanchez-Olguin

Zamudio

Guzmán-Velázquez

et al. 2022

Developmental Psychobiology

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Cerebrolysin enhances the expression of the synaptogenic protein LRRTM4 in the hippocampus and improves learning and memory in senescent rats

Flores-Páez

Pacheco-Rosado²,

Alva-Sánchez³

et al. 2019

Behavioural Pharmacology

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Aging reduces the efficiency of the organs and systems, including the cognitive functions. Brain aging is related to a decrease in the vascularity, neurogenesis, and synaptic plasticity. Cerebrolysin, a peptide and amino acid preparation, has been shown to improve the cognitive performance in animal models of Alzheimer’s disease. Similarly, the leucine-rich repeat transmembrane 4 protein exhibits a strong synaptogenic activity in the hippocampal synapses. The aim of this study was to evaluate the effect of the cerebrolysin treatment on the learning and memory abilities, sensorimotor functions, and the leucine-rich repeat transmembrane 4 protein expression in the brain of 15-month-old rats. Cerebrolysin (1076 mg/kg) or vehicle was administered to Wistar rats intraperitoneally for 4 weeks. After the treatments, learning and memory were tested using the Barnes maze test, and the acoustic startle response, and its pre-pulse inhibition and habituation were measured. Finally, the leucine-rich repeat transmembrane 4 expression was measured in the brainstem, striatum, and hippocampus using a Western-blot assay. The 15-month-old vehicle-treated rats showed impairments in the habituation of the acoustic startle response and in learning and memory when compared to 3-month-old rats. These impairments were attenuated by the subchronic cerebrolysin treatment. The leucine-rich repeat transmembrane 4 protein expression was lower in the old vehicle-treated rats than in the young rats; the cerebrolysin treatment attenuated that decrease in the old rats. The leucine-rich repeat transmembrane 4 protein was not expressed in striatum or brainstem. These results suggest that the subchronic cerebrolysin treatment enhances the learning and memory abilities in aging by increasing the expression of the leucine-rich repeat transmembrane 4 protein in the hippocampus.

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Sub-Chronic Cerebrolysin Treatment Attenuates the Long-lasting Behavioral Alterations Caused by Maternal Separation in Rats

Cited by 2 publications

References 58 publications

Neonatal ventral hippocampus lesion disrupts maternal behavior in rats: An animal model of schizophrenia

Neonatal ventral hippocampus lesion disrupts maternal behavior in rats: An animal model of schizophrenia

Cerebrolysin enhances the expression of the synaptogenic protein LRRTM4 in the hippocampus and improves learning and memory in senescent rats

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