Sub-chronic carbendazim exposure induces hepatic glycolipid metabolism disorder accompanied by gut microbiota dysbiosis in adult zebrafish (Daino rerio)

Zhaorigetu, Bao; Zhao, Yao; Wu, Anyi; Lou, Ze; Lu, Huahui; Yu, Qianxuan; Fu, Zhengwei; Jin, Yuanxiang

doi:10.1016/j.scitotenv.2020.140081

Cited by 60 publications

(35 citation statements)

References 70 publications

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“…Kaakoush and colleagues (59) have previously discussed the central role of Erysipelotrichaceae in host lipid metabolism and health in relation to diet specificities. The ZOR0006 genus has already been observed to decrease in fish gut microbiota after exposing zebrafish 21 days to high concentrations of antibiotics or fungicides (60,61). Interestingly, the drop of ZOR0006 abundance observed in this study occurs at a level between 10 and 100 µg.L -1 Chla.…”

Section: Discussionsupporting

confidence: 58%

Disruption of fish gut microbiota composition and holobiont’s metabolome by cyanobacterial blooms

Gallet

Halary

Duval

et al. 2021

Preprint

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Background: Cyanobacterial blooms are one of the most common stress encountered by metazoans living in freshwater lentic systems such as lakes and ponds. Blooms reportedly impair fish health, notably through oxygen depletion and production of bioactive compounds including cyanotoxins. However, in the times of the microbiome revolution, it is surprising that so little is still known regarding the influence of blooms on fish microbiota. In this study, an experimental approach is used to demonstrate that blooms affect fish microbiome composition and functions, as well as the metabolome of holobionts. To this end, the model teleost Oryzias latipes is exposed to simulated Microcystis aeruginosa blooms of various intensities in a microcosm setting, and the response of bacterial gut communities is evaluated in terms of composition, metagenome-encoded functions and metabolome profiling. Results: The gut bacterial community of O. latipes exhibits marked responses to the presence of M. aeruginosa blooms in a dose-dependent manner. Notably, abundant gut-associated Firmicutes almost disappear, while potential opportunists increase. The holobiont gut metabolome displays major changes, while functions encoded in the metagenome of bacterial partners are more marginally affected. Bacterial communities tend to return to original composition after the end of the bloom suggesting post-bloom resilience, and remain sensitive in case of a second bloom, reflecting a highly reactive gut community. Conclusion: In the context of increasingly frequent and intense blooms worldwide, results point to the relevance of accounting for short- and long-term microbiome-related effects in fish ecology, with potential outcomes relevant to conservation biology as well as aquaculture.

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Section: Discussionsupporting

confidence: 58%

Disruption of fish gut microbiota composition and holobiont’s metabolome by cyanobacterial blooms

Gallet

Halary

Duval

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Among these, Actinobacteria, Proteobacteria, Planctomycetes, and Firmicutes were the major phyla in the gut of the control and treatment groups, accounting for 85.85 and 87.59% of the total abundance, respectively, indicating the crucial role of core intestinal microbiota in generalized zebrafish. The results are in accordance with those of previous studies on the gut microbiota of zebrafish ( Bao et al, 2020 ; Kayani et al, 2021 ). Similar results were found in the water samples of aerated tap water and TWTP effluent exposures of 79.79 and 70.64%, respectively.…”

Section: Resultssupporting

confidence: 93%

Effect of Chronic Exposure to Textile Wastewater Treatment Plant Effluents on Growth Performance, Oxidative Stress, and Intestinal Microbiota in Adult Zebrafish (Danio rerio)

et al. 2021

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The ever-increasing production and processing of textiles will lead to greater risks of releasing pollutants into the environment. Textile wastewater treatment plants (TWTPs) effluent are an important source of persistent toxic pollutants in receiving water bodies. The effects of specific pollutants on organisms are usually studied under laboratory conditions, and therefore, comprehensive results are not obtained regarding the chronic combined effects of pollutants under aquatic environmental conditions. Thus, this study aimed to determine the combined effects of TWTP effluents on the growth performance, oxidative stress, inflammatory response, and intestinal microbiota of adult zebrafish (Danio rerio). Exposure to TWTP effluents significantly inhibited growth, exacerbated the condition factor, and increased the mortality of adult zebrafish. Moreover, markedly decreases were observed in the activities of antioxidant enzymes, such as CAT, GSH, GSH-Px, MDA, SOD, and T-AOC, mostly in the intestine and muscle tissues of zebrafish after 1 and 4 months of exposure. In addition, the results demonstrated that TWTP effluent exposure affected the intestinal microbial community composition and decreased community diversity. Slight changes were found in the relative abundance of probiotic Lactobacillus, Akkermansia, and Lactococcus in zebrafish guts after chronic TWTP effluent exposure. The chronic toxic effects of slight increases in opportunistic pathogens, such as Mycoplasma, Stenotrophomonas, and Vibrio, deserve further attention. Our results reveal that TWTP effluent exposure poses potential health risks to aquatic organisms through growth inhibition, oxidative stress impairment of the intestine and muscles, and intestinal microbial community alterations.

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“…The faecal analysis showed a strong decrement in Bacteroidetes after five days of exposure; conversely, the relative abundance of Firmicutes , Proteobacteria and Actinobacteria increased [ 98 ]. The abundance of Firmicutes , Bacteroidetes , Actinobacteria , Proteobacteria and Verrucomicrobia were decreased in the gut of zebrafish exposed to CBZ for 21 days [ 99 ]. Otherwise, difenoconazole led to an increment in Firmicutes , Proteobacteria ( Aeromonas and Enterobacteriaceae ) and Bacteroidetes ( Bacteroides ) [ 100 ].…”

Section: Fungicidesmentioning

confidence: 99%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides’ toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host–microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.

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Sub-chronic carbendazim exposure induces hepatic glycolipid metabolism disorder accompanied by gut microbiota dysbiosis in adult zebrafish (Daino rerio)

Cited by 60 publications

References 70 publications

Disruption of fish gut microbiota composition and holobiont’s metabolome by cyanobacterial blooms

Disruption of fish gut microbiota composition and holobiont’s metabolome by cyanobacterial blooms

Effect of Chronic Exposure to Textile Wastewater Treatment Plant Effluents on Growth Performance, Oxidative Stress, and Intestinal Microbiota in Adult Zebrafish (Danio rerio)

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

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