Sub-cellular accumulation of magnetic nanoparticles in breast tumors and metastases

Zhou, Jianxin; Leuschner, Carola; Kumar, Challa S. S. R.; Hormes, J.; Soboyejo, Winston O.

doi:10.1016/j.biomaterials.2005.10.013

Cited by 92 publications

(40 citation statements)

References 22 publications

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“…Most nanoparticles tend to accumulate in the liver (Zhou et al, 2006;Kamruzzaman et al, 2007;Sadauskas et al, 2007). They have been shown to be retained by the liver leading to tissue injury in mice (Wang et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Administration of nanoparticles resulted in depletion of reduced glutathione and oxidized glutathione, as well as these nanoparticles were distributed in the hepatocytes. The literature on rodent models in vivo strongly indicates that most naonparticles tend to accumulate in the liver (Zhou et al, 2006;Kamruzzaman et al, 2007;Sadauskas et al, 2007). They have been shown to be retained by the liver leading to tissue injury in mice (Wang et al, 2007).…”

Section: Science Publicationsmentioning

confidence: 99%

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Hepatoprotective Effect of N-Acetylcystiene on the Toxic Hazards of Titanium Dioxide Nanoparticles

Attia

Soliman

Abdel-Rahman

et al. 2013

American Journal of Pharmacology and Toxicology

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The present study was directed to evaluate the toxic effects of orally administered titanium dioxide naonparticles (TiO2) on liver of male albino rats and to evaluate the ameliorative effects of N-acetylcysteine (NAC). Forty adult male albino rats were divided into 4 groups; control group, NAC group, TiO2 group and TiO2/ NAC group. Rats were administered either TiO2 (1200 mg kg −1 BW) or NAC (100 mg kg −1 BW) alone or together for 9 months. Blood was taken to evaluate serum changes in GPT, GOT and MDA levels. Liver tissues were examined for changes in MDA, GSH and changes in liver histopathology. Administration of TiO2 increased serum GPT, GOT and decreased MDA levels. Co-treatment of rats with NAC and TiO2 improved such significant changes induced by TiO2 alone. Moreover, significant time dependent increase in MDA and decrease in GSH levels in liver tissues were recorded. Liver histopathology showed vacuolar, hydropic degeneration and cell death of some hepatic cells. In conclusion, results confirmed the protective effect of NAC in amelioration of the biohazard effects induced by TiO2 in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Science Publicationsmentioning

confidence: 99%

Hepatoprotective Effect of N-Acetylcystiene on the Toxic Hazards of Titanium Dioxide Nanoparticles

Attia

Soliman

Abdel-Rahman

et al. 2013

American Journal of Pharmacology and Toxicology

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show abstract

“…Most of nanoparticles tend to accumulate in the liver (Zhou et al, 2006;Kamruzzaman et al, 2007;Sadauskas et al, 2007) as well as spleen and kidney (Xue et al, 2011). It have been shown that inhalation of toxic substances modulated the secretion and/or peripheral sensitivity of cytokines and considered to be a controller of various peripheral metabolic functions including the control of lipid profiles (Xue et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of N-Acetylcystiene Against Titanium Dioxide Nanoparticles Modulated Immune Responses in Male Albino Rats

Soliman¹

2013

American Journal of Immunology

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The protective effects of N-acetylcysteine (NAC) against orally administered titanium dioxide nanoparticles (TiO2) for 3 months on male albino rats were examined. Adult male albino rats were given saline as a control group, TiO2 (1200 mg kg −1 BW), NAC (100 mg kg −1 BW) and co-treatment of NAC and TiO2 as a protective group for 3 months. Blood was assayed for serum changes in GPT, GOT, lipid profiles, cytokines and immunoglobulins profiles. Moreover, spleen was examined for alterations in cytokines expression and histopathology. Administration of TiO2 significantly increased serum levels of GPT, GOT and increased lipid profiles. Administration of NAC to TiO2 rats improved significant changes induced by Tio2 alone. There were an increase in IL-1β and IL-6 secretion in TiO2 administered rats which is normalized by NAC administration. Tio2 administration down regulated IL-8 and IL-10 secretion, while co-administration of rats by NAC together with TiO2 normalized that down regulation. Moreover, TiO2 induced toxicity in spleen that accompanied by a decrease in IgA, IgG and IgM that are normalized by NAC administration. Finally, Tio2 up-regulated IL-1β, IL-6 and TNF-β expression in spleen and NAC administration together with TiO2 normalized cytokines expression. In conclusion, present findings confirmed the protective effect of NAC on TiO2 induced alteration in immune responses in male albino rats.

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“…Supermagnetic nanoparticles (such as ultrasmall superparamagnetic iron oxide [USPIO] nanoparticles) are of particular use to enhance MRI as they themselves generate a magnetic field, which affects the surrounding tissue, giving significant signal amplification to the area on the scan [4,5,11,12]. They have been used in breast cancer rat models to highlight the leaky microvasculature of breast carcinomas (using the MRI data), which can correlate with tumor grade and differentiate them from benign breast lesions [13].…”

Section: Imagingmentioning

confidence: 99%

“…They have been used in breast cancer rat models to highlight the leaky microvasculature of breast carcinomas (using the MRI data), which can correlate with tumor grade and differentiate them from benign breast lesions [13]. Additionally, luteinizing hormone-releasing hormone (LHRH) conjugated USPIOs have been shown to enhance MRI and microscopy of LHRH receptor-expressing breast cancers (and their lung metastases) in mouse models [12]. These supermagnetic nanoparticles have also been conjugated with antibodies against HER2, which potentially enables simultaneous imaging and therapy of breast cancer [2,11,14].…”

Section: Imagingmentioning

confidence: 99%

Impact of nanotechnology in breast cancer

Haq

Zabkiewicz

Grange

et al. 2009

Expert Review of Anticancer Therapy

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Sub-cellular accumulation of magnetic nanoparticles in breast tumors and metastases

Cited by 92 publications

References 22 publications

Hepatoprotective Effect of N-Acetylcystiene on the Toxic Hazards of Titanium Dioxide Nanoparticles

Hepatoprotective Effect of N-Acetylcystiene on the Toxic Hazards of Titanium Dioxide Nanoparticles

Protective Effect of N-Acetylcystiene Against Titanium Dioxide Nanoparticles Modulated Immune Responses in Male Albino Rats

Impact of nanotechnology in breast cancer

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