SU59. Prevalence of Psychotic Experiences and Traumatic Events in the 2013 Thai National Mental Health Survey

Abstract

Background: Studies examining individual obstetric complications with the strongest associations with schizophrenia have the potential to help elucidate the etiology of schizophrenia, both by pointing the way to molecular studies and through an examination of their synergistic interaction with other risk factors. Here, we update our previous systematic review and meta-analysis on the association between obstetric complications and schizophrenia (Cannon et al, 2002) and examine individual obstetric complications of note. Methods: We conducted a systematic review of all published literature using Medline, Embase, and PubMED, searched the reference lists of published paper, and contacted authors in the field. In keeping with our previous meta-analysis, new studies were included only if they had prospective population-based data. Obstetric complications that were examined in 2 or more studies were included. Results: Low birth-weight and unwantedness of pregnancy were examined in 2 or more population-based studies since 2002. The pooled OR for the association between low birth-weight (<2500 g) and schizophrenia was 1.1 (95% CI: 0.6-1.6), indicating that there was no significant increase in the odds of those with a low birth-weight developing schizophrenia compared to those within the healthy birth-weight range. The pooled OR for the association between unwanted pregnancy and schizophrenia was 1.8 (95% CI: 1.1-2.5), indicating a 1.8-fold increase in the odds of those whose mothers described the pregnancy as unwanted developing schizophrenia compared to those who whose mothers did not describe the pregnancy as unwanted. There was very low heterogeneity in effect sizes across studies for both of these associations. Conclusion:This work provides epidemiological evidence of the importance of investigating key prenatal risk factors and the importance of psychological factors during pregnancy that may affect both maternal and fetal well-being. Reference Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002;159(7):1080-92. SU58. SEVERE MENTAL ILLNESS: WHERE TO IMPROVE QUALITY OF DIABETES MELLITUS CAREAnita Toender*, Mogens Vestergaard, Trine Munk-Olsen, and Thomas Munk Laursen Aarhus University Background: Severe mental illness (SMI) constitutes a high risk of physical morbidity and physical-related mortality, especially related to diabetes mellitus. Disparities in access to high-quality diabetes mellitus care are suggested to explain a major part of the higher mortality, but information about where to intervene specifically is needed. Hence, we aim to examine if persons with SMI and diabetes mellitus are treated with new improved antiglycemic medication to a lesser degree than persons with diabetes mellitus only. Methods: We will perform a cohort study and use national populationbased registers to identify and follow persons with SMI, type 2 diabetes mellitus and examine their use of the new improved anti-glycemic medication (dipeptidyl peptida...