Su2092 A High Fat Lower Fiber Dietary Intervention Perturbs the Urinary Metabonome and Gut Microbial Co-Metabolic Processes in a Population of African and African Americans

Li, Jia; Lahti, Leo; Ou, Junhai; Carbonero, Franck; Vipperla, Kishore; Ruder, Elizabeth H.; Newton, Keith; Naidoo, V.G.; DeLany, James P.; Zoetendal, Erwin G.; Gaskins, H. Rex; O’Keefe, Stephen J.; Nicholson, Jeremy K.

doi:10.1016/s0016-5085(14)61970-3

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The serum TG, TC, LDLC, and HDLC levels of mice were assessed as shown in Table S3. Compared to the fiber-rich diets, red meat and low fiber diet significantly promoted the accumulation of serum lipid and cholesterol, which may be because of perturbation of dietary fat metabolism by other components of the cometabolism pathway. , …”

Section: Resultsmentioning

confidence: 98%

“…Compared to the fiber-rich diets, red meat and low fiber diet significantly promoted the accumulation of serum lipid and cholesterol, which may be because of perturbation of dietary fat metabolism by other components of the cometabolism pathway. 33,34 Next, the ability of the gut microbiota induced by the defined diets to convert dietary choline to TMA and TMAO were assessed. Results showed that the red meat and lower fiber diet were correlated significantly with an increased TMA level, TMAO production, and TMA lyase activity (Figure 1c).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Correlation between Dietary Fiber-Suppressed Microbial Conversion of Choline to Trimethylamine and Formation of Methylglyoxal

Chen

Zhang

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

Dietary interventions alter the formation of the disease-associated metabolite, trimethylamine (TMA), via intestinal microbial TMA lyase activity. Nevertheless, the mechanisms regulating microbial enzyme production are still unclear. Sequencing of the gut bacteria 16S rDNA demonstrated that dietary intervention changed the composition of the gut microbiota and the functional metagenome involved in the choline utilization pathway. Characterization of the functional profile of the metagenomes and metabonomics analysis revealed that a series of Kyoto Encyclopedia of Genes and Genomes orthologous groups and enzyme groups related to accumulation of methylglyoxal (MG) and glycine were enriched in red meat diet-fed animals, whereas fiber-rich diet suppressed glycine formation via the MG-dependent pathway. Our observations suggest associations between choline–TMA lyase expression and MG formation, which are indicative of a novel role of the gut microbiota in choline metabolism and highlight it as a potential target for inhibiting TMA production.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: ■ Results and Discussionmentioning

confidence: 99%