Su2012 A First Case Report of Colorectal Cancer Associated With Chronic Strongyloides Stercoralis Colitis and the Complex Management Decisions That Follow

Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: A systematic review

“…The mechanisms of action to promote malignancy from a parasitic infection reported here include chronic inflammation, genomic instability, activation of invasion, angiogenesis and metastasis, dysregulation of tumor suppressor genes, alteration of Wnt pathway, sustained cell proliferation, inhibition of apoptosis, modulation of energetic metabolism and evasion of immune response . Based on our results, it seems that carcinogenesis associated with parasite infections can be triggered by various mechanisms different from that the so‐called “chronic inflammatory infection process” (Table ).…”

“…Inflammation drives reactive oxygen species (ROS) generation that promotes the acquisition of mutations. This has been described in chronic infections by T. muris, P. fastosum, C. parvum, T. gondii, T. vaginalis, F. gigantica and S stercoralis . In vitro, chronic T. muris infection initiated the tumor development and increased the number of tumors in two cancer‐model mice suggesting that T. muris is associated with exacerbated intestinal tumors .…”

“…The trematode P. fastosum was found in cholangiocarcinoma in liver from cats, the development of such tumor was presumed to be associated with the chronic infection by this parasite . S. stercoralis eggs and adult worms were found into the moderately differentiated gastric adenocarcinoma and colon adenocarcinoma of two human cases, but causality cannot be determined . A significant correlation was found between the number of endogenous developmental stages of C. parvum and the development of high‐grade intestinal dysplasia, thus demonstrating the impact of parasite load on neoplastic transformation .…”

“…This has been described in chronic infections by T. muris, P. fastosum, C. parvum, T. gondii, T. vaginalis, F. gigantica and S stercoralis. [9][10][11][12][13][14][15][16][17] In vitro, chronic T. muris infection initiated the tumor development and increased the number of tumors in two cancer-model mice suggesting that T. muris is associated What's new? Certain parasites may do more than cause chronic health problems.…”

NK Cells in Cancer Immunotherapy

“…For example, Strongyloides stercoralis infection was associated with an increased occurrence of lymphoid cancers [67]. An association of colorectal cancer with chronic S. stercoralis infection has also been reported in a Columbian patient [68]. This nematode is not only a cofactor for the development of lymphoid cancers induced by HTLV-1 [69] but is also associated with the development of colon adenocarcinoma by activating the host immune response.…”