Su1966 An Assessment of Cognitive Function in Irritable Bowel Syndrome (IBS): Are Deficits in Visuo-Spatial Memory Stress-Related and Mediated by Tryptophan Metabolism Along the Kynurenine Pathway?

Kennedy, Paul; Clarke, Gerard; O'Neill, Ann; Groeger, John A.; Quigley, Eamonn Martin; Shanahan, Fergus; Cryan, John F.; Dinan, Timothy G.

doi:10.1016/s0016-5085(12)62105-2

Cited by 2 publications

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“…Cognitive alterations may be present in individuals with IBS, and evidence is emerging that specific changes relate to hippocampal-mediated visuospatial memory deficits, which are linked to indices of HPA axis function ( 20 , 496 – 498 ). IBS patients also show impairments in tests of cognitive flexibility and have abnormal brain activity in frontal regions of the brain ( 499 ).…”

Section: The Relationship Between the Microbiota Hpa Axis And Cognitionmentioning

confidence: 99%

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

2023

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Cognitive function in humans depends on the complex and interplay between multiple body systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which vastly outnumbers human cells and has a genetic potential that exceeds that of the human genome, plays a crucial role in this interplay. The microbiota-gut-brain (MGB) axis is a bidirectional signalling pathway that operates through neural, endocrine, immune, and metabolic pathways. One of the major neuroendocrine systems responding to stress is the HPA axis which produces glucocorticoids such as cortisol in humans and corticosterone in rodents. Appropriate concentrations of cortisol are essential for normal neurodevelopment and function, as well as cognitive processes such as learning and memory, and studies have shown that microbes modulate the HPA axis throughout life. Stress can significantly impact the MGB axis via the HPA axis and other pathways. Animal research has advanced our understanding of these mechanisms and pathways, leading to a paradigm shift in conceptual thinking about the influence of the microbiota on human health and disease. Preclinical and human trials are currently underway to determine how these animal models translate to humans. In this review article, we summarize the current knowledge of the relationship between the gut microbiota, HPA axis, and cognition, and provide an overview of the main findings and conclusions in this broad field.

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Section: The Relationship Between the Microbiota Hpa Axis And Cognitionmentioning

confidence: 99%

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

2023

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“…Recently IBS patients were found to exhibit visuospatial memory deficits (Kennedy et al, 2013). However, a prospective assessment is essential to confirm if cognitive dysfunction is a stable feature of IBS.…”

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confidence: 99%

A Prospective Study of Cognitive Performance in Irritable Bowel Syndrome: Visuospatial Memory Deficits as a Stable Feature

Kennedy

Clarke

Allen

et al. 2013

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Introduction The cognitive neurobiological model of IBS (Kennedy et al., 2012), a disorder of the brain-gut axis, proposes that key pathophysiological features, such as altered hypothalamic-pituitary-adrenal (HPA) axis function, or heightened immune activity, may lead to impaired cognitive performance. Recently IBS patients were found to exhibit visuospatial memory deficits (Kennedy et al., 2013). However, a prospective assessment is essential to confirm if cognitive dysfunction is a stable feature of IBS. Aims/Background To prospectively assess visuospatial memory performance in IBS, in comparison to disease controls Crohn's diesase (CD] and healthy controls (HC). Method At baseline (Visit 1) and 6 months (Visit 2), IBS patients (baseline n=39; age (M): 28 yrs; IQ:105.5), matched CD patients (baseline n=18;age (M):32 yrs; IQ:103.4), and matched HC (baseline n=40;age (M):28 yrs; IQ:108.5), were assessed using a selection of cognitive tests from the CANTAB and Stroop test. Abdominal pain severity at time of testing was reported by IBS patients on a scale ranging from 0–100. Results At Visit 1 & 2, IBS patients displayed visuospatial memory deficits [Paired Associates Learning (PAL) test]; greater errors at the 6 pattern stage (baseline: p<0.05), which also approached significance across Visit 1 & 2 (p=0.05); greater number of trials needed to complete the PAL Visit 1 & 2 (p<0.05). Pain severity did not correlate with PAL performance (p>0.05). Conclusion Visuospatial memory dysfunction is a stable feature of IBS. These results may inform future management of this debilitating disorder in which there is a great unmet medical need.

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Su1966 An Assessment of Cognitive Function in Irritable Bowel Syndrome (IBS): Are Deficits in Visuo-Spatial Memory Stress-Related and Mediated by Tryptophan Metabolism Along the Kynurenine Pathway?

Cited by 2 publications

References 0 publications

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

A Prospective Study of Cognitive Performance in Irritable Bowel Syndrome: Visuospatial Memory Deficits as a Stable Feature

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