Su1917 FAECAL MYELOPEROXIDASE - A POTENTIAL NON-INVASIVE BIOMARKER OF DISEASE ACTIVITY IN INFLAMMATORY BOWEL DISEASE (IBD)

Swaminathan, Akhilesh; Borichevsky, Grace; Hoskin, Teagan; Mules, Thomas; Day, Andrew S.; Hampton, Mark B.; Kettle, Anthony J.; Gearry, Richard

doi:10.1016/s0016-5085(20)32443-4

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“…Patients with IBD undergoing ileocolonoscopy within the Canterbury or West Coast regions of New Zealand were prospectively recruited into the new indicators of disease activity in IBD (NIDA‐IBD) study between April 2019 and September 2020 12 . Eligible study participants were aged 16 years or older and had an established diagnosis of CD or UC.…”

Section: Methodsmentioning

confidence: 99%

The disease severity index for inflammatory bowel disease is associated with psychological symptoms and quality of life, and predicts a more complicated disease course

Swaminathan

Fan

Borichevsky

et al. 2022

Aliment Pharmacol Ther

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Summary Background The Disease Severity Index (DSI) is a novel tool to predict disease severity in inflammatory bowel disease (IBD). However, its ability to predict disease complications and the presence of psychosocial comorbidity is unclear. Aims: To assess prospectively associations between the DSI and psychological symptoms, quality‐of‐life (QoL) and disease outcomes in an IBD cohort. Methods Patients with IBD undergoing ileocolonoscopy were followed prospectively for 12 months. DSI, psychological symptoms (perceived stress (PSS‐10), depression (PHQ‐9), anxiety (GAD‐7)) and QoL (IBDQ‐32) scores were assessed at baseline. Logistic regression identified variables predicting a complicated IBD course at 12 months (composite outcome of need for escalation of biological/immunomodulator for disease relapse, recurrent corticosteroid use, IBD‐related hospitalisation and surgery). Receiver operating characteristics (ROC) analysis identified optimal DSI thresholds predicting a complicated disease course and multivariable logistic regression assessed the risk of reaching this outcome. Results One hundred and seventy‐two patients were recruited (100 Crohn's disease, 91 female). Median DSI was 21 (IQR 11–32) and 97 patients had endoscopically active disease at baseline. The DSI was significantly higher in patients with symptoms of moderate–severe stress (PSS‐10 > 14, p < 0.01), depression (PHQ‐9 ≥ 10, p < 0.01), anxiety (GAD‐7 ≥ 10, p < 0.05) and impaired quality‐of‐life (IBDQ‐32 < 168, p < 0.01). Only the baseline DSI (OR 1.05, p < 0.01) and endoscopically active disease (OR 6.12, p < 0.01) were associated with a complicated IBD course. A DSI > 23 was strongly predictive of a complicated IBD course (OR 8.31, p < 0.001). Conclusions The DSI is associated with psychological distress, impaired QoL and predicts a more complicated disease course in patients with IBD.

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Section: Methodsmentioning

confidence: 99%