Su1805 Increased Risk of Gastrointestinal (GI) Bleeding With Selective Serotonin Reuptake Inhibitors (SSRI), Used Alone and With NSAIDs: Meta-Analysis of Case-Control Studies

SSRI and the Risk of Gastrointestinal Bleed: More than What Meets the Eye

“…We had reported results on the same topic at Digestive Diseases Week in 2012 ( 2 ) and it is heartening to know that the results of the published meta-analysis are similar, despite slight diff erences in study selection. Th rough this letter, we will like to highlight certain aspects of literature that may contribute to the ongoing discussion of this important topic.…”

“…Hence, the seemingly trivial NNH of 881 becomes much more relevant in the subgroup with the highest To the Editor: We appreciate the interest in our recent systematic review and meta-analysis on the risk of upper gastrointestinal bleeding (GIB) with selective serotonin reuptake inhibitors (SSRIs) with or without concurrent nonsteroidal antiinfl ammatory (NSAID) use ( 1 ). In their letter, Atreja et al suggest we include two additional case-control studies in our meta-analysis ( 2,3 ). Th e fi rst study by Barbui et al ( 2 ) was excluded as a risk of GIB with SSRIs was provided, but no specifi c data on upper GIB were included.…”